A case of Mikulicz’s disease with Th2-biased cytokine profile: possible feature discriminable from Sjögren’s syndrome

Kudo-Tanaka, Eriko; Nakatsuka, Shin‐ichi; Hirano, Tôru; Kawai, Masao; Katada, Yoshinori; Matsushita, M.; Ohshima, Shiro; Ishii, Masaru; Miyatake, Kunio; Tanaka, Toshio; Saeki, Yukihiko

doi:10.3109/s10165-009-0214-9

Cited by 20 publications

(7 citation statements)

References 10 publications

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“…Indeed, a case of IgG4-RD showed an elevated level of serum IL-4, 56 and PBMCs from a patient showed the enhanced production of IL-4, IL-5 and IL-13, but not that of interferon gamma (IFN-c). 57 In another case study, peripheral CD4 + T cells deviated to IL-4-positive cells rather than IFN-c-positive cells. 58 In addition, a messenger RNA analysis of involved tissues revealed that the expression levels of Th2 cytokines such as IL-4, IL-5, IL-10 and IL-13 were significantly high and the expression levels of IL-4 and IL-10 were correlated with the IgG4 : IgG ratio.…”

Section: Acquired Immunity and The Th2 Responsementioning

confidence: 94%

“…A modified Th2 response with induced Tregs may be a pathological feature of IgG4‐RD. Indeed, a case of IgG4‐RD showed an elevated level of serum IL‐4, and PBMCs from a patient showed the enhanced production of IL‐4, IL‐5 and IL‐13, but not that of interferon gamma (IFN‐γ) . In another case study, peripheral CD4 + T cells deviated to IL‐4‐positive cells rather than IFN‐γ‐positive cells .…”

Section: Suspected Pathogenesis Of Igg4‐rdmentioning

confidence: 97%

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IgG4‐related disease

Kubo

Yamamoto

2015

Int J of Rheum Dis

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Immunoglobulin G4-related disease (IgG4-RD) is a regional or systemic fibro-inflammatory disease of unknown etiology. It presents a distinctive histopathological appearance of dense lymphoplasmacytic infiltrates with abundant IgG4-positive plasma cells, storiform fibrosis and obliterative phlebitis with the appearance of inflammatory swelling or tumefactive lesions. This new disease entity includes a wide variety of diseases such as Mikulicz disease, autoimmune pancreatitis, Riedel thyroiditis, interstitial nephritis and retroperitoneal fibrosis. Glucocorticoid therapy can resolve the clinical and pathological abnormalities and impaired organ function. IgG4-RD was recognized internationally in 2011, and new evidence has accumulated regarding its pathogenesis, clinical features and treatment. In this review, we outline our present understanding of IgG4-RD.

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Section: Acquired Immunity and The Th2 Responsementioning

confidence: 94%

Section: Suspected Pathogenesis Of Igg4‐rdmentioning

confidence: 97%

IgG4‐related disease

Kubo

Yamamoto

2015

Int J of Rheum Dis

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“…In addition, a malignant disease cannot be ruled out because the mass is unilateral, often leaving no choice other than excision. IgG4 related sclerosing disease occurs relatively often among cases of submandibular gland excision and suspected cases of SS (wherein the diagnostic criteria are not satisfied) 18 – 20…”

Section: Discussionmentioning

confidence: 99%

A new category for chronic sclerosing sialadenitis as an IgG4 related syndrome

Nagai¹,

Andoh²,

Ogata³

et al. 2010

Case Reports

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This report presents three cases of IgG4 related sclerosing disease complicated with chronic sclerosing sialadenitis. The clinical, radiographic and pathologic findings later suggested that the patients had chronic sclerosing sialadenitis. The submandibular gland tumour regressed in two patients. These patients were suspected to have Mikulicz's disease or Sjögren's syndrome, but the diagnostic criteria were not satisfied. The workup for chronic sclerosing sialadenitis revealed a significantly elevated value of serum IgG4. The patient was then diagnosed with IgG4 related sclerosing disease complicated with chronic sclerosing sialadenitis. After administering prednisolone to these patients, the serum IgG4 values decreased after 4 weeks. The current cases may represent a new category for Mikulicz's disease or Sjögren's syndrome as an IgG4 related sclerosing disease.

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“…The cytokine profile of Mikulicz's disease shows that Th2 and Treg cells are predominant [ 45 , 136 ]. In addition, IL-21, which is secreted by cytotoxic T cells, is overexpressed in Mikulicz's disease and is involved in germinal center formation and IgG4 class-switching [ 14 , 137 – 140 ].…”

Section: Mikulicz's Disease (Igg4-rds)mentioning

confidence: 99%

T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis

Ibrahem

2022

Autoimmune Diseases

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IgG4-related disease is a multiorgan immunological fibroinflammatory disorder characterized by lymphoplasmacytic infiltration and fibrosis in multiple organs accompanied by high serum IgG4 levels. The salivary glands are the most common organs involved in this disease. Recently, chronic sclerosing sialadenitis affecting salivary glands, formerly known as Küttner’s tumor, and Mikulicz’s disease have been classified as a class of IgG4-related diseases. The etiopathobiology of IgG4-related disease is not fully understood. It has recently been hypothesized that the inflammatory and fibrotic process and the increased serum IgG4+ levels in IgG4-related disease are the result of an interaction between B cells and T helper cells, suggesting that T cells may play a key role in the pathogenesis of this disease. The aim of this review is to discuss the proposed roles of different T cell subsets in the pathogenesis of IgG4-related disease focusing on their roles in immunopathogenesis of IgG4-related sialadenitis.

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A case of Mikulicz’s disease with Th2-biased cytokine profile: possible feature discriminable from Sjögren’s syndrome

Cited by 20 publications

References 10 publications

IgG4‐related disease

IgG4‐related disease

A new category for chronic sclerosing sialadenitis as an IgG4 related syndrome

T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis

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