A Case of Methyl Salicylate Intoxication Treated by Exchange Transfusion

Adams, Julius T.; Bigler, John A.; Green, Orville C.

doi:10.1001/jama.1957.72980300009009c

Cited by 22 publications

(12 citation statements)

References 3 publications

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“…The ingestion of approximately 4 mL of oil of wintergreen (AED 5,600 mg, 378 mg/kg) by a 21-month-old boy resulted in moderate toxicity (45). Ingestion of less than 5 mL of oil of wintergreen (AED 7000 mg, 486 mg/kg) by a 20-month-old boy resulted in severe toxicity (41). The lowest dose of methyl salicylate associated with death was approximately 5 mL of oil of wintergreen ingested by a 2 1 / 2 -year-old boy (AED 7,000 mg, 432 mg/kg) (42).…”

Section: Methyl Salicylatementioning

confidence: 99%

“…In numerous cases, initially mild symptoms of gastrointestinal irritation (e.g., burning sensation or vomiting) were followed by the development of systemic effects up to 15 hours later (41,49,51). In other cases, exact times were not available, but the onset of significant systemic effects appeared to be delayed by several hours after ingestion (42,43).…”

Section: Methyl Salicylatementioning

confidence: 99%

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Salicylate poisoning: An evidence-based consensus guideline for out-of-hospital management

Chyka

Erdman

Christianson

et al. 2007

Clinical Toxicology

113

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American Association of Poison Control Centers, Washington, District of Columbia, USAA review of U.S. poison center data for 2004 showed over 40,000 exposures to salicylate-containing products. A guideline that determines the conditions for emergency department referral and pre-hospital care could potentially optimize patient outcome, avoid unnecessary emergency department visits, reduce health care costs, and reduce life disruption for patients and caregivers. An evidence-based expert consensus process was used to create the guideline. Relevant articles were abstracted by a trained physician researcher. The first draft of the guideline was created by the lead author. The entire panel discussed and refined the guideline before distribution to secondary reviewers for comment. The panel then made changes based on the secondary review comments. The objective of this guideline is to assist poison center personnel in the appropriate out-of-hospital triage and initial out-of-hospital management of patients with a suspected exposure to salicylates by 1) describing the process by which a specialist in poison information should evaluate an exposure to salicylates, 2) identifying the key decision elements in managing cases of salicylate exposure, 3) providing clear and practical recommendations that reflect the current state of knowledge, and 4) identifying needs for research. This guideline is based on an assessment of current scientific and clinical information. The expert consensus panel recognizes that specific patient care decisions may be at variance with this guideline and are the prerogative of the patient and the health professionals providing care, considering all of the circumstances involved. This guideline does not substitute for clinical judgment. Recommendations are in chronological order of likely clinical use. The grade of recommendation is in parentheses: 1) Patients with stated or suspected self-harm or who are the victims of a potentially malicious administration of a salicylate, should be referred to an emergency department immediately. This referral should be guided by local poison center procedures. In general, this should occur regardless of the dose reported (Grade D).2) The presence of typical symptoms of salicylate toxicity such as hematemesis, tachypnea, hyperpnea, dyspnea, tinnitus, deafness, lethargy, seizures, unexplained lethargy, or confusion warrants referral to an emergency department for evaluation (Grade C). 3) Patients who exhibit typical symptoms of salicylate toxicity or nonspecific symptoms such as unexplained lethargy, confusion, or dyspnea, which could indicate the development of chronic salicylate toxicity, should be referred to an emergency department (Grade C). 4) Patients without evidence of self-harm should have further evaluation, including determination of the dose, time of ingestion, presence of symptoms, history of other medical conditions, and the presence of co-ingestants. The acute ingestion of more than 150 mg/kg or 6.5 g of aspirin equivalent, whichever is less, war...

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Section: Methyl Salicylatementioning

confidence: 99%

Section: Methyl Salicylatementioning

confidence: 99%

Salicylate poisoning: An evidence-based consensus guideline for out-of-hospital management

Chyka

Erdman

Christianson

et al. 2007

Clinical Toxicology

113

View full text Add to dashboard Cite

show abstract

“…A dose of 30 ml concentrated methyl salicylate (-0.5 g/kg) may be fatal to adults, while as little as 4-10 ml may be fatal to infants or r-hildren, depending on i;he size and conditio, of the child (Stecher, 1968;Adams et al, 1957;Cann and Verhuist, 1958;Canselmo, 1948;Deichmann and Gerarde, 1969;Wade, 1977).…”

Section: Acute Toxicitymentioning

confidence: 99%

“…In severe cases, generalized convulsions and coma are followed by cardiovascular collapse and respiratory insufficiency leading to death within 1'-36 hours after exposure (Adams et al, 1957;Stecher, 1968;Deichmann and Gerarde, 1969).…”

Section: *mentioning

confidence: 99%

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Development of Candidate Chemical Simulant List: The Evaluation of Candidate Chemical Simulants Which May Be Used in Chemically Hazardous Operations

CAMBRIDGE¹

1982

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Two Cases of Salicylate Intoxication Successfully Treated by Exchange Transfusion

RENTSCH¹

1959

Arch Pediatr Adolesc Med

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A Case of Methyl Salicylate Intoxication Treated by Exchange Transfusion

Cited by 22 publications

References 3 publications

Salicylate poisoning: An evidence-based consensus guideline for out-of-hospital management

Salicylate poisoning: An evidence-based consensus guideline for out-of-hospital management

Development of Candidate Chemical Simulant List: The Evaluation of Candidate Chemical Simulants Which May Be Used in Chemically Hazardous Operations

Two Cases of Salicylate Intoxication Successfully Treated by Exchange Transfusion

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