A Case of Metastasis to the Seminal Vesicle of Renal Cell Carcinoma

Yamamoto, Shinya; Mamiya, Yoshimi; Noda, Kenjiro; Samejima, Takeshi; Miki, Makoto; Akasaka, Y

doi:10.5980/jpnjurol1989.89.563

Cited by 3 publications

(2 citation statements)

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“…Most apparent tumors of the seminal vesicle originate from prostate cancer by direct invasion or metastasis [2]. To our knowledge only 1 case of metastasis to the seminal vesicle from a renal cell carcinoma has previously been reported, unfortunately in a Japanese patient [3]. This is the first case in the Western world.…”

Section: Discussionmentioning

confidence: 82%

An Unusual Cause of Irritable Urinary Bladder Symptoms

Reisman

Reijke

2001

Urol Int

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A metastasis from a renal cell carcinoma to a seminal vesicle is extremely rare. This pattern of metastatic disease has been reported once previously in the Japanese literature. We describe a patient with irritability symptoms of the urine bladder and involuntary loss of stool caused by obstruction of the bladder by a large metastasis from a renal cell carcinoma to the seminal vesicle. The mode of diagnosis and treatment of this patient are described.

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Section: Discussionmentioning

confidence: 82%

An Unusual Cause of Irritable Urinary Bladder Symptoms

Reisman

Reijke

2001

Urol Int

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“…This model thus has higher clinical relevance over subcutaneous mouse models for preclinical evaluation of cell carrier-based RCC tumor targeting. Although the risk of seminal vesicle metastasis of human RCC is relatively low by clinical observation, − using luciferase-tagged hMSC cells as a noninvasive imaging modality, we clearly showed that i.p. administered hMSC cells progressively and preferentially localized in orthotopic RCC tumors and their developed seminal vesicle metastases.…”

Section: Discussionmentioning

confidence: 83%

Vitamin D₃-Inducible Mesenchymal Stem Cell-Based Delivery of Conditionally Replicating Adenoviruses Effectively Targets Renal Cell Carcinoma and Inhibits Tumor Growth

Hsiao¹,

Sung²,

Liao³

et al. 2012

Mol. Pharmaceutics

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Cell-based carriers were recently exploited as a tumor-targeting tool to improve systemic delivery of oncolytic viruses for cancer therapy. However, the slow clearance of carrier cells from normal organs indicates the need for a controllable system which allows viral delivery only when the carrier cells reach the tumor site. In this study, we sought to develop a pharmaceutically inducible cell-based oncolytic adenovirus delivery strategy for effective targeting and treatment of renal cell carcinoma (RCC), which is one of the most malignant tumor types with an unfavorable prognosis. Herein, we demonstrated the intrinsic tumor homing property of human bone marrow-derived mesenchymal stem cells (hMSCs) to specifically localize primary and metastatic RCC tumors after systemic administration in a clinically relevant orthotopic animal model. The platelet derived growth factor AA (PDGF-AA) secreted from RCC was identified as a chemoattractant responsible for the recruitment of hMSCs. Like endogenous osteocalcin whose barely detectable level of expression was dramatically induced by vitamin D(3), the silenced replication of human osteocalcin promoter-directed Ad-hOC-E1 oncolytic adenoviruses loaded in hMSCs was rapidly activated, and the released oncolytic adenoviruses sequentially killed cocultured RCC cells upon vitamin D(3) exposure. Moreover, the systemic treatment of RCC tumor-bearing mice with hMSC cell carriers loaded with Ad-hOC-E1 had very limited effects on tumor growth, but the loaded hMSCs combined with vitamin D(3) treatment induced effective viral delivery to RCC tumors and significant tumor regression. Therapeutic effects of hMSC-based Ad-hOC-E1 delivery were confirmed to be significantly greater than those of injection of carrier-free Ad-hOC-E1. Our results presented the first preclinical demonstration of a novel controllable cell-based gene delivery strategy that combines the advantages of tumor tropism and vitamin D(3)-regulatable human osteocalcin promoter-directed gene expression of hMSCs to improve oncolytic virotherapy for advanced RCC.

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Etiologic classification, evaluation, and management of hematospermia

Suh¹,

Gandhi²,

Joshi³

et al. 2017

Transl. Androl. Urol.

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Hematospermia is defined by the presence of blood in the semen typically occurring in men younger than 40 years of age. Symptoms can occur due to a multitude of reasons, but are usually benign and self-limiting, requiring no additional treatment or evaluation. Despite this, the condition often impairs quality of life due to associated anxiety and must be taken seriously by the patient and the physician, particularly if recurrent, refractory, and painful. The etiology of hematospermia can be classified into inflammatory, infectious, lithiasis, cystic, obstructive, tumoral, vascular, traumatic, iatrogenic, and systemic origin. Alternatively, it can also be divided into subcategories based on anatomical origins such as prostate, bladder, spermatic cord, seminal vesicles, or epididymis. A complete history and physician examination, laboratory testing, and a variety of invasive and non-invasive imaging and instrumentation modalities can help to identify and treat the underlying pathology promptly.

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A Case of Metastasis to the Seminal Vesicle of Renal Cell Carcinoma

Cited by 3 publications

References 0 publications

An Unusual Cause of Irritable Urinary Bladder Symptoms

An Unusual Cause of Irritable Urinary Bladder Symptoms

Vitamin D₃-Inducible Mesenchymal Stem Cell-Based Delivery of Conditionally Replicating Adenoviruses Effectively Targets Renal Cell Carcinoma and Inhibits Tumor Growth

Etiologic classification, evaluation, and management of hematospermia

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A Case of Metastasis to the Seminal Vesicle of Renal Cell Carcinoma

Cited by 3 publications

References 0 publications

An Unusual Cause of Irritable Urinary Bladder Symptoms

An Unusual Cause of Irritable Urinary Bladder Symptoms

Vitamin D3-Inducible Mesenchymal Stem Cell-Based Delivery of Conditionally Replicating Adenoviruses Effectively Targets Renal Cell Carcinoma and Inhibits Tumor Growth

Etiologic classification, evaluation, and management of hematospermia

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Vitamin D₃-Inducible Mesenchymal Stem Cell-Based Delivery of Conditionally Replicating Adenoviruses Effectively Targets Renal Cell Carcinoma and Inhibits Tumor Growth