A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe

Hovius, Joppe W.; Wever, Bob de; Söhne, Maaike; Brouwer, Matthijs C.; Coumou, Jeroen; Wagemakers, Alex; Oei, Arlene L.; Knol, Henrike; Narasimhan, Sukanya; Hodiamont, Caspar J.; Jahfari, Setareh; Pals, Steven T.; Horlings, Hugo M.; Fikrig, Erol; Sprong, Hein; Oers, Marinus H. J. van

doi:10.1016/s0140-6736(13)61644-x

Cited by 230 publications

(262 citation statements)

References 6 publications

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“…23,45,46 Recent work has also implicated it as a potential cause of meningoencephalitis. 47,48 The prevalence of Anaplasma spp. infection in our study was 1.7%.…”

Section: Discussionmentioning

confidence: 99%

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. Croatia is a focus for many rodent-borne zoonosis. Here, we report a survey of 242 rodents and small mammals, including 43 Myodes glareolus, 131 Apodemus flavicollis, 53 Apodemus agrarius, three Apodemus sylvaticus, six Sorex araneus, four Microtus arvalis, one Microtus agrestis, and one Muscardinus avellanarius, collected at eight sites in Croatia over an 8-year period. Multiplex MassTag polymerase chain reaction (PCR) was used for detection of Borrelia, Rickettsia, Bartonella, Babesia, Ehrlichia, Anaplasma, Francisella tularensis, and Coxiella burnetii. Individual PCR assays were used for detection of Leptospira, lymphocytic choriomeningitis virus, orthopoxviruses, flaviviruses, hantaviruses, and Toxoplasma gondii. Of the rodents, 52 (21.5%) were infected with Leptospira, 9 (3.7%) with Borrelia miyamotoi, 5 (2%) with Borrelia afzelii, 29 (12.0%) with Bartonella, 8 (3.3%) with Babesia microti, 2 (0.8%) with Ehrlichia, 4 (1.7%) with Anaplasma, 2 (0.8%) with F. tularensis, 43 (17.8%) with hantaviruses, and 1 (0.4%) with an orthopoxvirus. Other agents were not detected. Multiple infections were found in 32 rodents (13.2%): dual infections in 26 rodents (10.7%), triple infections in four rodents (2.9%), and quadruple infections in two rodents (0.8%). Our findings indicate that rodents in Croatia harbor a wide range of bacteria and viruses that are pathogenic to humans.

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“…23,45,46 Recent work has also implicated it as a potential cause of meningoencephalitis. 47,48 The prevalence of Anaplasma spp. infection in our study was 1.7%.…”

Section: Discussionmentioning

confidence: 99%

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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“…Ezért magyarországi előfordulásával is számolni kell. Egyelőre sokkal több országban találtak a kullancsokban B. miyamotoi-t, mint amennyiben humán megbetegedést észleltek (1. és 3. táblázat [34][35][36][37][38][39][40]). Ez érthető, hiszen mind a klinikai, mind a laboratóriumi diagnózis nehézkes.…”

Section: Klinikum éS Epidemiológiaunclassified

“…Bm = Borrelia miyamotoi; Rf = visszatérő lázat okozó baktérium (Relapsing fever) ÖSSZEFOGLALÓ KÖZLEMÉNY szenvedő, immunszupprimált emberben alakult ki meggyőzően alátámasztott, B. miyamotoi által okozott meningoencephalitis [34,35]. Mindegyik esetben lymphocytás pleocytosis és magas fehérjeszint volt a likvorban, ugyanúgy, mint a Lyme-betegségben.…”

Section: Klinikum éS Epidemiológiaunclassified

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Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

Szekeres

Lakos²,

Földvári

2017

Orvosi Hetilap

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A Borrelia miyamotoi-t 1995-ben fedezték fel. Ez egy, emberben visszatérő lázat (relapsing fever, febris recurrens) okozó baktérium, amelyet az Ixodes ricinus fajcsoportba tartozó kullancsok terjesztenek. Ez a kórokozó genetikailag, járványtanilag és az általa okozott kórkép tekintetében is különbözik a szintén kullancsok által terjesztett Borrelia burgdorferi sensu lato (Lyme spirochaeta) baktériumoktól. Eddig világszerte több mint 50 heveny lázas megbetegedésben szenvedő páciensből mutatták már ki, ezenfelül három tumoros betegben meningoencephalitist okozott ez a kórokozó. A különböző élőhelyeken található kullancsok és gazdáik fertőzöttségének mértéke, eloszlása és a fertőzés mechanizmusa nem tisztázott még. A B. miyamotoi elsősorban lázat okoz, ami miatt más, kullancsok által terjesztett fertőzésekkel is összetéveszthető. Az utóbbi évek intenzív vizsgálatai alapján nemcsak egyre több földrajzi régióból mutatják ki ezt a baktériumot kullancsokból, de folyamatosan növekszik a publikált humán esetszám is, ezért növek-vő jelentőségű (emerging) kórokozóként tartják számon. Irodalmi áttekintésünkben összegezzük az eddigi ismereteinket a Borrelia miyamotoi-val kapcsolatban. Orv Hetil. 2017; 158(29): 1124-1130. Kulcsszavak: Borrelia miyamotoi, kullancs, visszatérő láz, kullancs által terjesztett fertőzések Borrelia miyamotoi: a recently identified human pathogenic tick-borne relapsing fever spirocheteBorrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the Ixodes ricinus complex. This pathogen is different from Borrelia burgdorferi sensu lato (the Lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. Over 50 patients have been described worldwide with Borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. Our knowledge about Borrelia miyamotoi infection in ticks and its distribution in different habitats and also the mechanism of the infection is limited. The most common symptom is fever; thus it can be easily confused with other tick-borne diseases. Due to the intensive research in recent years, Borrelia miyamotoi infection in ticks and hosts has been reported from different regions and also the number of patients is increasing, thus this bacterium is considered as an emerging pathogen. In this literature review we would like to summarize the available knowledge about this spirochete.

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“…In Europe, the most prevalent tick-borne disease in humans is Lyme borreliosis (LB), caused by a group of bacteria belonging to the Borrelia burgdorferi sensu Iato group with at least five different species infecting humans in Europe [1]. Recently, B. miyamotoi, belonging to the more distantly related relapsing fever group, has been detected in patients in USA, Japan, Russia and The Netherlands [2][3][4][5], and is transmitted by the tick species involved in LB. Ticks can also be infected with other pathogens that might be transmitted to humans [6] (see Table 1).…”

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confidence: 99%

Emerging Horizons for Tick-Borne Pathogens: From the ‘One Pathogen–one Disease’ Vision to the Pathobiome Paradigm

et al. 2015

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Ticks, as vectors of several notorious zoonotic pathogens, represent an important and increasing threat for human and animal health in Europe. Recent applications of new technology revealed the complexity of the tick microbiome, which may affect its vectorial capacity. Appreciation of these complex systems is expanding our understanding of tick-borne pathogens, leading us to evolve a more integrated view that embraces the 'pathobiome'; the pathogenic agent integrated within its abiotic and biotic environments. In this review, we will explore how this new vision will revolutionize our understanding of tickborne diseases. We will discuss the implications in terms of future research approaches that will enable us to efficiently prevent and control the threat posed by ticks.

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A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe

Cited by 230 publications

References 6 publications

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

Emerging Horizons for Tick-Borne Pathogens: From the ‘One Pathogen–one Disease’ Vision to the Pathobiome Paradigm

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