A case of Ménétrier's disease localized to the gastric antrum without helicobacter infection or hypoalbuminemia

Sweeney, Adam R.; Lynch, Maureen K.

doi:10.1016/j.ijscr.2013.07.004

Cited by 10 publications

(21 citation statements)

References 8 publications

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“…The hypertrophy of the mucosa is not caused by infiltrative carcinoma, lymphoma, tuberculosis, sarcoidosis or syphilis 1. The disease mostly affects middle-aged men, while in paediatrics, affliction is relatively rare 2. It predominates in body-fundus or antrum or may involve the entire stomach.…”

Section: Discussionmentioning

confidence: 99%

“…In adults, Helicobacter pylori , rather than Cytomegalovirus, is thought to play a role 3. The proposed mechanism is mucosal damage caused by infection with Cytomegalovirus or H. pylori , which increases the production of abnormal local transforming growth factor-α (TNF-α) 2 3. TNF-α is the key regulator for increased rugal growth and mucus secretion.…”

Section: Discussionmentioning

confidence: 99%

“…TNF-α is the key regulator for increased rugal growth and mucus secretion. Besides, it diminishes gastric secretions 2 3. Protein loss in the form of mucus leads to hypoproteinaemic manifestations.…”

Section: Discussionmentioning

confidence: 99%

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An unusual association of Ménétrier's disease with a gastric bezoar

2015

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Ménétrier’s disease is a rare protein-losing hypertrophic gastroenteropathy. While it still remains a medical curiosity, infection with Cytomegalovirus andHelicobacter pylori, and hormonal, congenital, dietary and neurogenic factors have been postulated as causative factors. We describe a case of a 14-year boy who presented with epigastric discomfort, vomiting, inability to gain weight and pedal oedema. Investigations revealed hypoproteinaemia without proteinuria and elevated faecal α-1-antitrypsin levels suggestive of protein-losing enteropathy. Imaging and endoscopic features demonstrated cerebriform gastric folds indicative of Ménétrier’s disease. Infective, hormonal and neurogenic causes were ruled out in our patient. Surprisingly, the patient had a history of pica and an associated large gastric bezoar, which was ultimately removed surgically. An association of Ménétrier’s disease with a bezoar has been reported only once previously. We thus add to the existing literature and highlight the plausible role of a bezoar as a causative factor in the pathogenesis of Ménétrier’s disease due to its irritant nature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An unusual association of Ménétrier's disease with a gastric bezoar

2015

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“…It is characterized by hypoproteinemia, hypo or achlorhydria, gastric hypertrophy and increased risk of gastric adenocarcinoma. Histopathologically, it is evidenced by foveolar infiltration which replaces normal glandular architecture and, in some cases, Helicobacter pylori colonization [1].…”

Section: Discussionmentioning

confidence: 99%

“…These changes occur primarily at the gastric body and is associated with hypoproteinemia, hypochlorhydria or achlorhydria [1].…”

Section: Introductionmentioning

confidence: 99%

Robot-assisted laparoscopic gastrectomy for Menetrier’s disease

et al. 2015

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Menetrier's disease, also known as hypoproteinemic hypertrophic gastropathy, is a rare condition characterized by the presence of gastric hypertrophy with foveolar infiltration that replaces the normal glandular architecture. We present a case of a 65-year-old female patient who had epigastric pain after meals which progressed to oral intolerance and weight loss. Upper endoscopy was performed showing prominent folds in the gastric mucosa and stenosis at the antrum-pylorus. Biopsy was taken and showed foveolar reactive hyperplasia and reactive glandular epithelium changes suggestive of Menetrier's disease. An abdominopelvic CT was performed showing a dilated stomach and gastric wall thickening. The patient was taken into the operation room for a robot-assisted total gastrectomy with esophagus-jejunum anastomosis. The patient's progress was satisfactory and he was discharged on the eighth postoperative day. Robot-assisted laparoscopic gastrectomy is a feasible and safe option that facilitates the performance of complex procedures.

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A case of Menetrier’s disease without Helicobacter pylori or hypoalbuminemia

Azer¹,

Sultan²,

Zalata

et al. 2015

International Journal of Surgery Case Reports

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HighlightsMenetrier’s disease is a rare premalignant hypertrophic gastropathy.We describe a case of Menetrier’s disease with an unusual presentation, without Helicobacter pylori or hypoalbuminemia.Menetrier’s disease should be suspected in cases of upper GIT symptoms and hypertrophied gastric mucosa with or without Helicobacter pylori or hypoalbuminemia.Surgical management is a good option when medical treatment fails to relieve the symptoms and erase the risk of malignancy.

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A case of Ménétrier's disease localized to the gastric antrum without helicobacter infection or hypoalbuminemia

Abstract: This case may represent an unreported subset of MD where limited surgical resection is demonstrated to offer an exceptional outcome.

Cited by 10 publications

References 8 publications

An unusual association of Ménétrier's disease with a gastric bezoar

An unusual association of Ménétrier's disease with a gastric bezoar

Robot-assisted laparoscopic gastrectomy for Menetrier’s disease

A case of Menetrier’s disease without Helicobacter pylori or hypoalbuminemia

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