“…We read with interest the article by Cai et al 1 about a 23-year-old male with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome due to the m.3243A>G variant. The patient manifested phenotypically with epilepsy, quadriparesis,wasting, generalized hypotonia, bilateral facial palsy, dysarthria, dysphagia, anemia, lactic acidosis, polyneuropathy, and abdominal pain.…”