A case of maxillary sarcoma in a chimpanzee (<i><scp>P</scp>an troglodytes</i>)

Fujisawa, Michiko; Udono, Toshifumi; Nogami, Etsuko; Hirosawa, Moe; Morimura, Naruki; Saito, Akatsuki; Şereş, M.; Teramoto, Migaku; Nagano, Koyo; Mori, Yumiko; Uesaka, Hiromi; Nasu, K; Tomonaga, Masaki; Idani, Gen’ichi; Hirata, Satoshi; Tsuruyama, Tatsuaki; Matsubayashi, Kiyoaki

doi:10.1111/jmp.12086

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Cardiac function [198] and disease [199,200] have been investigated in both chimpanzees and bonobos, as well as improvements to cardiac monitoring [201] and heart rate responses to anaesthetic protocols [202]. At Kumamoto, clinical cases of maxillary sarcoma [203], leprosy [204] and Down syndrome [205] have all been reported in chimpanzees, while researchers have also investigated a non-invasive test for tuberculosis in PASA sanctuaries [206]. Parasitology research has been conducted at a number of PASA sanctuaries, including a multi-institutional investigation of Trypanosoma brucei, the parasite responsible for sleeping sickness [207], which used samples from sanctuaryhoused gorillas at Limbe Wildlife Center in Cameroon (hereafter Limbe) and chimpanzees from several facilities.…”

Section: (C) Veterinary Genetic and Physiologymentioning

confidence: 99%

A review of research in primate sanctuaries

Ross

Leinwand

2020

Biol. Lett.

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While non-human primate studies have long been conducted in laboratories, and more recently at zoological parks, sanctuaries are increasingly considered a viable setting for research. Accredited sanctuaries in non-range countries house thousands of primates formerly used as subjects of medical research, trained performers or personal pets. In range countries, however, sanctuaries typically house orphaned primates confiscated from illegal poaching and the bushmeat and pet trafficking trades. Although the primary mission of these sanctuaries is to rescue and rehabilitate residents, many of these organizations are increasingly willing to participate in non-invasive research. Notably, from a scientific standpoint, most sanctuaries provide potential advantages over traditional settings, such as large, naturalistic physical and social environments which may result in more relevant models of primates' free-ranging wild counterparts than other captive settings. As a result, an impressive scope of research in the fields of primate behaviour, cognition, veterinary science, genetics and physiology have been studied in sanctuaries. In this review, we examine the range and form of research that has been conducted at accredited sanctuaries around the world. We also describe the potential challenges of sanctuary-based work and the considerations that external researchers may face when deciding to collaborate with primate sanctuaries on their research projects.

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Section: (C) Veterinary Genetic and Physiologymentioning

confidence: 99%

A review of research in primate sanctuaries

Ross

Leinwand

2020

Biol. Lett.

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“…Except for a few short surveys of lesions and causes of mortality, an extensive documentation of chimpanzee lesions is lacking. Most of the published studies are in the form of case series that include pathology findings related to body systems (central nervous, cardiovascular, respiratory, gastrointestinal, urinary, and integumentary), etiologies (parasitic, degenerative, and neoplastic), and individual case reports . An extensive survey of the pathological lesions is lacking in literature.…”

Section: Introductionmentioning

confidence: 99%

Natural pathology of the captive chimpanzee (Pan troglodytes): A 35‐year review

Kumar

Laurence

Owston

et al. 2017

J of Medical Primatology

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Background We present the spontaneous pathological lesions identified as a result of necropsy or biopsy for 245 chimpanzees (Pan troglodytes) over a 35-year period. Methods A review of the pathology database was performed for all diagnoses on chimpanzees from 1980 to 2014. All morphologic diagnoses, associated system, organ, etiology, and demographic information were reviewed and analyzed. Results Cardiomyopathy was the most frequent lesion observed followed by hemosiderosis, hyperplasia, nematodiasis, edema, and hemorrhage. The most frequently affected systems were the gastrointestinal, cardiovascular, urogenital, respiratory, and lymphatic/hematopoietic systems. The most common etiology was undetermined, followed by degenerative, physiologic, neoplastic, parasitic, and bacterial. Conclusions Perinatal and infant animals were mostly affected by physiologic etiologies and chimpanzee-induced trauma. Bacterial and physiologic etiologies were more common in juvenile animals. Degenerative and physiologic (and neoplastic in geriatric animals) etiologies predominated in adult, middle aged, and geriatric chimpanzees.

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Comparative Pathology of Aging Great Apes

2015

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The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives. Despite the many similarities, there are significant differences in aging among apes, including the human ape. Common to all are dental attrition, periodontitis, tooth loss, osteopenia, and arthritis, although gout is uniquely human and spondyloarthropathy is more prevalent in apes than humans. Humans are more prone to frailty, sarcopenia, osteoporosis, longevity past reproductive senescence, loss of brain volume, and Alzheimer dementia. Cerebral vascular disease occurs in both humans and apes. Cardiovascular disease mortality increases in aging humans and apes, but coronary atherosclerosis is the most significant type in humans. In captive apes, idiopathic myocardial fibrosis and cardiomyopathy predominate, with arteriosclerosis of intramural coronary arteries. Similar cardiac lesions are occasionally seen in wild apes. Vascular changes in heart and kidneys and aortic dissections in gorillas and bonobos suggest that hypertension may be involved in pathogenesis. Chronic kidney disease is common in elderly humans and some aging apes and is linked with cardiovascular disease in orangutans. Neoplasms common to aging humans and apes include uterine leiomyomas in chimpanzees, but other tumors of elderly humans, such as breast, prostate, lung, and colorectal cancers, are uncommon in apes. Among the apes, chimpanzees have been best studied in laboratory settings, and more comparative research is needed into the pathology of geriatric zoo-housed and wild apes. Increasing longevity of humans and apes makes understanding aging processes and diseases imperative for optimizing quality of life in all the ape species.

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A case of maxillary sarcoma in a chimpanzee (Pan troglodytes)

Cited by 4 publications

References 13 publications

A review of research in primate sanctuaries

A review of research in primate sanctuaries

Natural pathology of the captive chimpanzee (Pan troglodytes): A 35‐year review

Comparative Pathology of Aging Great Apes

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