A Case of Massive Metoprolol Overdose Successfully Managed

Bala, Poppy; Ali, Atahar; Rahman, Kazi Atiqur; Islam, Nighat; Khan, Mahmood Hasan

doi:10.3329/bhj.v35i1.49147

Cited by 1 publication

(4 citation statements)

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“…It has moderate lipid solubility and blocks β1 adrenergic receptors. It is reported that the threshold value is 400 mg in adults and 5mg/kg in children (9). Metoprolol overdose, depending on the dose taken in the clinic, may lead to symptoms such as bradycardia, hypotension, cardiogenic shock, hypoglycemia, hypothermia, seizure, altered consciousness, QT prolongation and QRS enlargement (10).…”

Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

“…Due to its lipophilic properties, the drug crosses the bloodbrain barrier in β-blocker poisoning and central nervous system effects may be observed. Therefore, rapid airway management is important in such patients (9). In literature, majority of the publications recommend gastric lavage and the administration of activated charcoal in β-blocker poisoning (11,12).…”

Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

“…In case of seizures in β-blocker poisoning, the first choice is benzodiazepines. If there is QTc prolongation, magnesium sulfate is given; if QRS widening is present, sodium bicarbonate is given in the treatment (9). In the treatment of hypotension and shock, IV fluids and ketocalamine and/or high-dose insulin euglycemic treatments are recommended.…”

Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

“…More extensive studies are needed to investigate the efficacy of this treatment. Since metoprolol is not a water-soluble drug, hemodialysis treatment has no efficacy on it (9). Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) therapy also plays an active role in β-blocker poisoning in cardiogenic shock resistant to all pharmacotherapy.…”

Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

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A Case of High Dose Metoprolol Poisoning; Case Report and Literature Review

Ocak¹,

Çetinkaya

Kesim

2021

İJCMBS

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β-Blockers are prescribed by physicians for many medical reasons (hypertension, long-term prophylaxis of angina pectoris, myocardial infarction, stable heart failure treatment, cardiac arrhythmias, etc.). Although cases of β-blocker poisoning have a low rate of 0.9% among all poisoning cases, they have a high mortality rate. In β-blocker poisoning with high lipid solubility; seizures, respiratory depression, coma, resistant bradycardia-hypotension and shock may occur. Metoprolol, a type of β-blocker, is a selective β1-adrenoceptor antagonist with sympathomimetic effect. It is also reported that metoprolol is the 2nd most commonly prescribed β-blocker after bisoprolol all over the world. This article aims to present a case who took high-dose metoprolol for suicidal purposes and to examine metoprolol poisoning and its treatment in the light of current literature.

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Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

Section: Figure 1 Drug Particles Visible In the Stomach Lumen On The Patient's Abdominal Tomographymentioning

confidence: 99%

See 2 more Smart Citations