A case of mammary-type myofibroblastoma of the inguinal region

Ishihara, Atsushi; Yasuda, Takeo; Sakae, Yukari; Sakae, Masayuki; Hamada, T; Tsukazaki, Hideki; Tsukazaki, Takashi; Furumoto, Masaru

doi:10.1016/j.ijscr.2018.11.048

Cited by 6 publications

(7 citation statements)

References 14 publications

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“…MTMF, proposed as an independent entity in 2001, is a very rare, benign, mesenchymal tumor occurring outside the breast. So far, more than 160 cases have been reported[ 2 , 4 , 5 ]. Adults aged 40-60 years are predisposed to MTMF, with men predominating slightly[ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Adults aged 40-60 years are predisposed to MTMF, with men predominating slightly[ 4 ]. The tumor has extensive anatomic distribution; the groin and inguinal regions might be the most common sites[ 4 , 5 ]. Clinically, MTMF usually presents as a painless, slowly growing mass.…”

Section: Discussionmentioning

confidence: 99%

“…It is usually well-circumscribed, encapsulated or unencapsulated, and composed of haphazardly arranged fascicles of spindle cells admixed with various amounts of adipocytes in a collagenous, hyalinizing, or myxoid background[ 3 , 4 ]. In immunohistochemical (IHC) results, the spindle cells often characteristically express both cluster of differentiation 34 (CD34) and desmin (Des)[ 1 , 4 , 5 ]. Genetically, MTMF belongs to “the 13q/retinoblastoma (Rb) family of tumors”, which are featured by deletion or rearrangement of the 13q14 region, resulting in loss of the Rb gene and Rb protein expression[ 4 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Mammary-type myofibroblastoma with infarction and atypical mitosis-a potential diagnostic pitfall: A case report

Zeng¹,

Dai²,

Chen³

2022

WJCC

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BACKGROUND Mammary-type myofibroblastoma (MTMF) is a rare benign extramammary soft tissue tumor with myofibroblastic differentiation. Although 160 cases of MTMF have been reported in the literature since 2001, no cases of infarction or atypical mitosis have been reported so far. Herein, we report an unusual case of MTMF in the pelvic cavity, which mimicked some malignant features, including infarction, atypical mitosis, infiltrative growth, and prominent cytologic atypia, making it difficult to ascertain whether the tumor was benign. CASE SUMMARY A 49-year-old man complained of pain and discomfort in the right buttock for more than 4 mo and did not receive any treatment. Nuclear magnetic resonance imaging (MRI) showed a 13-cm-sized mass in his right pelvic cavity. Histologically significant differences were atypical mitosis figures and multiple necrotic foci in the tumor. In addition, smooth muscle and skeletal muscle were invaded within and at the edge of the tumor. These morphologic features are often reminiscent of malignant tumors and therefore pose a diagnostic challenge to pathologists. The tumor cells were strongly positive for both cluster of differentiation 34 and desmin, and the loss of retinoblastoma 1 shown by immunohistochemical and fluorescence in situ hybridization results confirmed the pathological diagnosis of MTMF. Currently, the patient is alive and in good condition without tumor recurrence or metastasis after 2.5 years of follow-up by telephone and MRI. CONCLUSION The two pseudo-malignant characteristics of infarction and atypical mitosis broaden the morphological lineage of MTMF, a rare mesenchymal tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mammary-type myofibroblastoma with infarction and atypical mitosis-a potential diagnostic pitfall: A case report

Zeng¹,

Dai²,

Chen³

2022

WJCC

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“…Clinically, extramammary myofibroblastoma tends to present as a slow‐growing painless mass or incidental finding 3,5 . It is most common in the fifth and sixth decades, having been reported in patients ranging from age 4 to 96 years, and has a slight male predominance 3,9 . Although size is not reported for all cases in the literature, a previous review found a mean tumor size of 5.5 cm, and tumors as large as 34 cm have been described 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Extramammary myofibroblastoma is commonly described as being variably positive for AR, ER, and PR. Though available data are limited to a few small case series and some case reports, cases of MF with positivity for a single, a combination of two, or all three steroid hormone receptors have been reported 5,9,13–18 . Conversely, 96% of SCLs are AR+, 19 and PR expression in SCL is rare 20 .…”

Section: Discussionmentioning

confidence: 99%

Extramammary myofibroblastoma of the oral cavity

et al. 2022

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Myofibroblastoma is a rare, benign mesenchymal tumor first described as a neoplasm of the breast. Extramammary myofibroblastoma is a histopathologically and genetically identical lesion occurring outside the breast. Herein is presented a case of extramammary myofibroblastoma arising in the oral cavity. A 59-year-old woman presented with a 1.5 cm nodule on the buccal surface of the lower lip. Wide local excision was performed. Histopathologic examination revealed haphazard fascicles of monomorphic spindle cells with hyalinized collagen bundles without fat. The spindled cells were diffusely positive for CD34, and focally for progesterone receptor. Desmin, smooth muscle actin, estrogen receptor, androgen receptor, S100, and STAT6 were negative. Rb1 expression was lost in tumor cells. Thus, the diagnosis of extramammary myofibroblastoma was made. Differential diagnoses include spindle-cell lipoma and angiofibroma. All three tumors are members of the 13q14 deletion/RB1 loss family. Indolent but locally aggressive (solitary fibrous tumor, desmoid fibromatosis) and frankly malignant (low-grade peripheral nerve sheath tumor, dermatofibrosarcoma protuberans) entities can be excluded by immunohistochemistry and careful microscopic examination. Extensive sampling extramammary myofibroblastoma is important to exclude the possibility of malignancy.Clinicians and pathologists alike should be aware of this entity and its potential to arise rarely in unusual locations.

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