A case of lymphangioma circumscriptum with new reflectance confocal microscopy findings

Karaarslan, Isil; Oraloğlu, Göktürk; Yaman, Banu

doi:10.1111/ajd.13545

Cited by 3 publications

(6 citation statements)

References 7 publications

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“…5 Isil Karaarslan and colleagues had reported a case of SLM with numerous hyper-refractile globular structures corresponding to lymphoid cells within the dark cavities revealed by RCM. 6 However, this differs from our case, as here only dark lacunae and a small number of hypo-refractile cells were observed. Our histopathological findings may be due to the dilated lymphatic channels were predominantly filled with lymphatic fluid and few lymphoid cells was detected.…”

Section: F I G U R Econtrasting

confidence: 96%

Detection of superficial lymphatic malformation with dermoscopy and reflectance confocal microscopy

Lin

Rao

Wang

2023

Skin Research and Technology

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BackgroundSuperficial lymphatic malformation (SLM) is a congenital disorder of the lymphatic channels. It usually appears as clusters of vesicles filled with lymphatic fluid and blood on the skin that resemble frogspawn, making it difficult to distinguish from haemangiomas, angiokeratomas, and pyogenic granulomas. Although pathological results have diagnostic values, the significance of noninvasive examination in the diagnosis and differential diagnosis is also worth exploring.Materials and MethodsA 24‐year‐old female presented with a history of multiple asymptomatic, pink lesions located on the chest since age 10. Histopathological examination was performed, and results informed the diagnosis of SLM. Lesions were detected by dermoscopy and reflectance confocal microscopy (RCM).ResultsDermoscopy (polarized, 30×) revealed multiple yellowish‐red lacunae in a light red background that were separated by pale septa and “hypopyon sign” was observed. RCM displayed a honeycomb pattern and multiple dark cavities in the upper dermal layers separated by thin septa with a few hypo‐refractile cells at the periphery that demonstrated slow fluid flow via dynamic scanning.ConclusionWe described a case of SLM detected by dermoscopy and RCM. Dermoscopic and RCM features may provide a potentially powerful, noninvasive instrument for the recognition and differentiation of SLM.

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Section: F I G U R Econtrasting

confidence: 96%

Detection of superficial lymphatic malformation with dermoscopy and reflectance confocal microscopy

Lin

Rao

Wang

2023

Skin Research and Technology

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“…In vivo reflectance confocal microscopy (RCM) disclosed: 1) numerous dark cavities in the epidermis and upper dermis, which correspond to lacunae; 2) high refraction well-delimited edges around dark spaces, corresponding to thin septa; 3) small shiny structures inside the cavities, which may correspond to lymphoid cells; 4) absence of or very low blood flow. 1 These findings coincide with what was identified in the confocal microscopy analysis of the patient in the present case, allowing the observation of the structures and correlating them with what was seen on dermoscopy and histopathology.…”

supporting

confidence: 90%

“… 5 The diagnostic definition is complete, with the identification of thin-walled dilated lymphatic vessels on histopathology. 1 , 2 Such vessels were present on histopathology in the skin biopsy of the patient reported here. Imaging exams are important to assess the depth and allow the definition of the best therapeutic approach, with magnetic resonance imaging being the method of choice to date, not available in the present case.…”

supporting

confidence: 50%

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Confocal evaluation of lymphangioma circumscriptum

Silveira,

Quirino,

Barcaui

et al. 2024

Anais Brasileiros de Dermatologia

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“…Clinically, they appear as multiple, clustered or scattered, translucent or hemorrhagic vesicules resembling frog eggs composed of dilated lymphatic channels lined by flat endothelial cells located in the superficial dermis of the skin or the mucosa. The color of the vesicles varies according to the sero-hemorrhagic content of the lymphatic channels from tan-yellowish to red-black [ 17 ]. The acquired form of cutaneous lymphangiomas is most often found in the axillary, inguinal, and genital areas and it is mainly due to an alteration of the lymphatic circulation with coexisting lymphedema.…”

Section: Discussionmentioning

confidence: 99%

Non-Invasive Imaging for the Diagnosis of Genital Warts and Their Imitators

Cinotti,

Barbarossa,

Cortonesi

et al. 2024

JCM

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Genital warts are the most frequent sexually transmitted disease. Their clinical diagnosis is not always easy, and invasive skin biopsies for histological examination should be performed in these cases. The aim of the study was to investigate the use of non-invasive imaging techniques for the diagnosis of genital warts and their imitators. We retrospectively evaluated dermoscopy, reflectance confocal microscopy (RCM), and line-filed confocal microscopy (LC-OCT) images of nine patients with 19 warts of the mucous membranes and five patients with lesions that clinically mimic genital warts, including 12 molluscum contagiosum, 1 Fordyce’s spot and one case of multiple acquired lymphangiomas. Most genital warts (15; 79%) showed dilated vessels surrounded by a whitish halo at dermoscopy. RCM and the new device LC-OCT could identify near histologic features such as the presence of hyperkeratosis, acanthosis, papillomatosis and enlarged vessels in all genital warts. However, the identification of koilocytes, which are the hallmark for the diagnosis of warts, was still difficult using both techniques. Non-invasive imaging techniques could also offer clues for the correct diagnosis of the imitators. This study confirmed the usefulness of dermoscopy in recognizing a precise pattern in warts and showed the potential use of RCM and LC-OCT to add additional findings to the clinical and dermoscopic examination.

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A case of lymphangioma circumscriptum with new reflectance confocal microscopy findings

Abstract: In vivo reflectance confocal microscopy (RCM) findings of lymphangiomas have been scarcely reported. We report a lymphangioma circumscriptum (LC) with some new observations.

Cited by 3 publications

References 7 publications

Detection of superficial lymphatic malformation with dermoscopy and reflectance confocal microscopy

Detection of superficial lymphatic malformation with dermoscopy and reflectance confocal microscopy

Confocal evaluation of lymphangioma circumscriptum

Non-Invasive Imaging for the Diagnosis of Genital Warts and Their Imitators

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