A Case of Lyme Disease Accompanied by Uveitis and White Dot Syndrome

Müftüoğlu, İlkay Kılıç; Akova, Yonca A.; Güngör, Sirel Gür

doi:10.4274/tjo.25991

Cited by 13 publications

(14 citation statements)

References 8 publications

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“… 41 , 42 , 46 , 47 There are reports of structural changes despite acuity of 20/20 on presentation, where symptoms resolve with treatment. 48 Because our PTLD cases had good visual acuity, and the large letter size in the Pelli–Robson chart helps ensure that refractive errors are not interfering with assessing contrast, 49 we do not feel this difference in contrast impairment is due to overt clinical disease in the cases. However, we did not do imaging and therefore cannot rule out more subtle ocular findings related to PTLD that might be associated with these changes.…”

Section: Discussionmentioning

confidence: 90%

Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease

Rebman

Yang

Mihm

et al. 2021

Trans. Vis. Sci. Tech.

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Purpose Posttreatment Lyme disease (PTLD) is marked by neurologic symptoms, cognitive impairment, and significant symptom burden, including fatigue and ocular complaints. The purpose of this study was to determine whether contrast sensitivity (CS) is altered in patients with PTLD compared with healthy controls and, second, whether CS is associated with cognitive and/or neurologic deficits. Methods CS was measured using a Pelli–Robson chart with forced-choice procedures, and the total number of letters read was recorded for each eye. CS impairment was defined for age <60 years as logCS of 1.80 (36 letters or fewer) and for those age ≥60 years as logCS of 1.65 (33 letters or fewer). Participants self-administered a questionnaire to assess presence of ocular symptoms and underwent a neurologic exam and battery of neurocognitive tests. Results CS impairment was associated with an increased odds of being in the PTLD group that was 2.6 times as high as those without CS impairment (odds ratio, 2.6; 95% confidence interval, 1.3–5.2). Neither cases nor controls had significant distance acuity impairment. CS impairment was not associated with any of the ocular complaints in cases but was borderline associated with neurologic abnormalities and cognitive impairment. Conclusions CS impairment in patients with PTLD is linked to signs of cognitive and neurologic impairment and may be a marker of illness severity. Translational Relevance Further investigation into the value of testing CS impairment in PTLD cases is warranted, especially if it is an indicator of cognitive or neurologic manifestations.

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Section: Discussionmentioning

confidence: 90%

Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease

Rebman

Yang

Mihm

et al. 2021

Trans. Vis. Sci. Tech.

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“…After the detailed search with the removal of duplicates and articles, which were non-full text or did not meet the PICO criteria (Table 1), a total number of 36 studies were included in our review. 8–43 None of the papers were meta-analyses or systematic reviews or randomised controlled trials.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of Lyme disease in Turkey

et al. 2019

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A systematic review was conducted with the aim of describing the demographical data, features and outcomes of patients with Lyme disease (LD), reported from Turkey. Three international database (electronic PubMed, Web of Science and Scopus) and two national database (Ulakbim and Turkmedline) searches were performed using the following keywords ([‘Lyme’ or ‘Borrelia burgdorferi’ or ‘Borrelia’ or ‘Borreliosis’] and ‘Turkey [and/country]’). National Notifiable Diseases Surveillance System (NNNDS) of Centers for Disease Control and Prevention (CDC) criteria were used for classification. A PRISMA-based algorithm was used for systematic review. There were a total of 75 LD cases in 36 different reports. Studies related to LD are confined to case reports. We believe that LD is an important healthcare problem in Turkey and to our knowledge this is the first systematic review from this country.

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“…Lyme disease can even manifest as white dot syndrome showing multifocal white dots in the posterior pole in addition to the more common findings such as retinal vasculitis and anterior or posterior chamber inflammation. Patients with Lyme disease and severe ocular involvement should be treated with systemic antibiotics and steroids (+/− topical steroids) [ 9 ]. A case of Lyme disease with a serous retinal detachment and chorioretinal folds was shown to be responsive to antibiotics alone [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Recurrent bilateral chorioretinitis with positive Lyme serology: a case report

Issa

DeSouza

2021

J Med Case Reports

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Background It has been disputed whether Lyme is a true causative agent in posterior uveitis or an incidental finding. Case presentation This report presents a case of a 33-year-old Caucasian female with a remote history of Lyme disease who presented with blurry vision in the right eye. Exam and imaging revealed a right active chorioretinitis and positive Lyme serology. The patient was systemically treated with prednisone and antibiotics. Symptoms initially improved, but she later developed a localized choriocapillaritis in the left eye. Steroids and antibiotics were restarted many times with fluctuating course of the disease. The patient was then started on chronic steroid-sparing immunosuppression, which has controlled the condition without recurrence. Conclusions The current report presents a unique case of recurrent bilateral chorioretinitis with positive Lyme serology and raises the question of the existence of true Lyme-associated uveitis.

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A Case of Lyme Disease Accompanied by Uveitis and White Dot Syndrome

Cited by 13 publications

References 8 publications

Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease

Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease

Systematic review of Lyme disease in Turkey

Recurrent bilateral chorioretinitis with positive Lyme serology: a case report

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