“…Indigo carmine (5,5′‐indigodisulfonic acid sodium salt or indigotine) (IC) is one of the earliest dark blue synthetic dyes used in food and drinks to improve appearance, color, taste, and texture 4,5 . Moreover, it has been used in the cosmetics, medicinal, and textile industries to color polyester and denim (blue jeans) fibers 6–8 . Nevertheless, IC is a highly toxic indigoid dye that causes skin and eye irritation, persistent corneal and conjunctival damage, and gastrointestinal tract irritation that causes nausea, vomiting, and diarrhea 9–11 .…”