A Case of Linear IgA/IgG Bullous Dermatosis with Anti-laminin-332 Autoantibodies

Izaki, Satoshi; Mitsuya, Juniku; Okada, Tomoko; Koga, Hiroshi; Hashimoto, Takashi; Terada, Tadashi

doi:10.2340/00015555-1923

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…Recently, immunoblot studies have indicated that LAGBD sera show circulating IgA and IgG antibodies reactive with various autoantigens: BP230, BP180 NC16a domain, 97/120‐kDa LAD‐1, BP180 C‐terminal domains, laminin‐332, 290‐kDa type‐VII collagen and 200‐kDa laminin‐γ1 . Our patient showed that IgG antibodies reacted with the BP180 NC16a domain and 120‐kDa LAD‐1 in immunoblotting analyses, and IgG antibodies to BP230 in ELISA.…”

Section: Discussionmentioning

confidence: 52%

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Linear immunoglobulin A/G bullous dermatosis associated with ulcerative colitis

Onoe

Matsuura

Terada

et al. 2017

The Journal of Dermatology

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Linear immunoglobulin (Ig)A/G bullous dermatosis (LAGBD) is an autoimmune bullous disease characterized by formation of subepidermal blisters and linear deposition of IgA and IgG antibodies along the basement membrane zone (BMZ). The association between linear IgA bullous dermatosis and ulcerative colitis (UC) is well recognized, but reports of UC-associated LAGBD are lacking. We have reported a 24-year-old man suffering from LAGBD associated with UC, which occurred before exacerbations of skin rash. A skin biopsy indicated a subepidermal blister with an infiltration of primarily neutrophils and eosinophils in the dermis. Direct immunofluorescence (IF) studies showed a linear deposition of IgA, IgG and C3c. Indirect IF of human skin revealed IgA and IgG anti-BMZ autoantibodies. Indirect IF of 1 M NaCl-split human skin demonstrated reactivity of IgA and IgG antibodies at the epidermal side. Immunoblotting showed that IgG antibodies reacted to the BP180 NC16a domain and 120-kDa linear IgA dermatosis-1, and enzyme-linked immunoassay detected IgG anti-BP230 antibodies. Administration of prednisolone and diaminodiphenyl sulfone (DDS) via the p.o. route improved skin lesions and bowel conditions. These results suggest that the bowel inflammation observed in UC may have a causative effect of initiation of the immune response to the skin and development of the bullous skin lesions in LAGBD. A combination of DDS and corticosteroid could be a recommended therapeutic option for patients with LAGBD with UC.

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Section: Discussionmentioning

confidence: 52%

“…Patients with LAGBD have responded well to DDS therapy in the same manner as that for LABD treatment . DDS has efficacy against skin diseases characterized by neutrophil‐rich infiltrates.…”

Section: Discussionmentioning

confidence: 99%

Linear immunoglobulin A/G bullous dermatosis associated with ulcerative colitis

Onoe

Matsuura

Terada

et al. 2017

The Journal of Dermatology

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“…1,2 In LABD, the target antigens are the 97-kDa or 120-kDa fractions of BP180 carboxyterminus. In LAGBD, IgG and IgA antibodies target BP180 most commonly, 4,10-14 and, less often, laminin-332 11,15,16 and BP230. 11,14,17 Drug-induced BP and LABD have been reported 1 ; there is, however, no specific association of LAGBD with drugs.…”

Section: Discussionmentioning

confidence: 99%

Immunologic overlap in a case of linear IgG/IgA bullous dermatosis responsive to rituximab

et al. 2021

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“…The term linear IgA/IgG bullous dermatosis was primarily used to describe patients with both IgA and IgG deposition at the basement membrane zone, and recently Izaki et al . reported a case of linear IgA/IgG bullous dermatosis with anti‐laminin‐332 autoantibodies …”

Section: Discussionmentioning

confidence: 99%