A Case of Linear IgA Bullous Dermatosis of Childhood: Immunoelectron Microscopic and IgA Subclass Studies

Onodera, Yuko; Hashimoto, Takashi; Miyakawa, Shin; Shimizu, Hiroshi; Nishikawa, Takeji; Yamamoto, Kazuya

doi:10.1159/000248045

Cited by 13 publications

(1 citation statement)

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“…Adachi et al (18) found IgA2 deposition in a patient who had sub-lamina densa deposition of antibody by immunoelectron microscopy. Onodera et al (19), described a patient with IgA1 and IgA2 BMZ antibodies on DIF with only the presence of circulating IgA1 antibodies.…”

Section: Discussionmentioning

confidence: 99%

IgA Antibodies Recognizing LABD97 Are Predominantly IgA1 Subclass

Egan

Martineau

Taylor

et al. 1999

Acta Dermato-Venereologica

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Linear IgA bullous dermatosis is a rare acquired subepidermal blistering disease of the skin. A recognized antigen in linear IgA bullous dermatosis is a 97-kDa basement membrane zone protein termed LABD97. Previous studies, using immunofluorescent techniques, have suggested that the IgA response is restricted to the IgA1 subclass. We studied the IgA antibody subclasses in the sera of 6 patients that contained circulating IgA antibodies reactive with LABD97. The methods used included direct and indirect immunofluorescence and Western immunoblot. All patients tested had IgA1 anti-LABD97 antibodies detected by all 3 methods. Two patients had IgA2 antibodies detected by direct immunofluorescence. Three patients had IgA2 antibodies on indirect immunofluorescence. Two of these also had anti-LABD97 IgA2 antibodies and 1 had secretory component containing anti-LABD IgA antibodies on Western immunoblot. We conclude that the predominant IgA antibody subclass reactive with LABD97 in LABD is IgA1, although the IgA2 subclass may be involved in some cases.

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Section: Discussionmentioning

confidence: 99%