A case of lethal neuroleptic malignant syndrome occurring after surgery.

Nomura, Tsutomu; Kohno, Masaki; Shingaki, Susumu; Nakajima, Tamio; Taguchi, Satoshi

doi:10.5794/jjoms.43.191

Cited by 3 publications

(2 citation statements)

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“…Although the results indicated that haloperidol was the drug most commonly used to cure postoperative delirium, statistical analysis is needed to determine whether haloperidol is a significant cause of NMS. In the group of NMS cases caused by abrupt drug discontinuation, the most common disease was schizophrenia, 16,[90][91][92][93][94]97,98,100,107,108,114 followed by Parkinson's disease 8,49,91,99,[103][104][105]110 (Table 12). In contrast to the first group, many drugs in this second group were causative, but none in particular.…”

Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

“…They could be classified into two groups: (1) cases in which NMS onset was triggered by administering causative drugs 17–19,22–89 and (2) cases in which NMS developed from disruption of regular medication (Tables 7 and 8). 8,16,90–114 An example of the former is a case in which antipsychotic drugs were administered for postoperative delirium; an example of the latter is a case in which regular medication (i.e., antipsychotic drugs) to treat schizophrenia was discontinued temporarily because of general anesthesia.…”

Section: Occurrences Of Nms In Fields Other Than Psychiatrymentioning

confidence: 99%

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Neuroleptic malignant syndrome in fields other than psychiatry

Shimada

Kase

Nakatsuru

et al. 2023

Oral Science International

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Neuroleptic malignant syndrome (NMS) is an adverse effect of drugs, mainly neuroleptics. It is characterized by problems related to the autonomic nervous system (such as hyperthermia, diaphoresis, and tachycardia) and extrapyramidal symptoms (such as muscle rigidity and tremor). After onset, NMS progresses rapidly and without treatment, becomes life‐threatening. In recent years, NMS has become better recognized, and treatment has improved; most cases are now curable before becoming dangerous. Most NMS reports are from psychiatrists or neurologists; few are from other specialized clinicians. However, nonpsychiatric clinicians, such as surgeons, emergency physicians, orthopedists, and oral surgeons, sometimes must administer neuroleptic drugs. Although NMS is rare, its effects on patients may be debilitating, and this places a heavy burden on clinicians. Thus, not only psychiatrists but also clinicians in various other fields should understand this illness. This article describes NMS in fields other than psychiatry and its diagnosis, risk factors, and treatment strategies.

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