A case of leiomyoadenomatoid tumour of uterine serosa: speculations about differential diagnosis

Abstract

Adenomatoid tumour is a benign rare lesion of the female genital tract, localised in the wall of fallopian tubes or beneath the uterine serosa. It is often accompanied by smooth muscle proliferation, obscuring the presence of adenomatoid tumour, resulting in misdiagnosis of cellular leiomyoma.Here, a case of uterine serosal adenomatoid tumour associated with multiple leiomyomas and pelvic endometriosis in a 44-year-old woman who underwent surgical removal for uterine bleeding and abdominal pain is presented.

Epididymal Leiomyoadenomatoid Tumor: A Case Report and Review of Literature

“…Nevertheless, there is very little smooth muscle in the epididymis. In the literature, 5 cases of leiomyoadenomatoid tumor have been reported: one in the epididymis and the others in the uterine wall, with one of them also affecting an ovary [5,6,7,8,9]. Adenomatoid tumors often affect the inferior pole and rigth side of the testicle, such as in the only case of the literature and in our case [8].…”

“…Adenomatoid tumors often affect the inferior pole and rigth side of the testicle, such as in the only case of the literature and in our case [8]. The histogenesis of leiomyoadenomatoid tumors is subject to debate [3,5,6,7]. Some authors support the hypothesis that this rare entity should be considered as a subtype of adenomatoid tumors, others think that it represents a collision neoplasia, and others think that it is the result of a common adenomatoid tumor associated to a reactive smooth muscle hyperplasia [3,5].…”

Leiomyoadenomatoid Tumor of the Uterus: Case Report

“…17 Yaptığımız araştırmalar sonucunda literatürde şu ana kadar çok az vakada leiomiyoadenomatoid tümör rapor edilmiştir. [8][9][10][11][12][13][14] Bu vakalardan erkeklerde görülenler genelde epididimde olup, kadın-larda ise daha çok uterusta gözükmeteydi. Literatür incelendiğinde sadece bir olguda tümör multisentrik olarak bulunmuş olup, diğer vakalarda tek odaklı tümör saptanmıştır.…”

“…Literatürde şu ana kadar bu tanıma uyan çok fazla vaka tanımlanmamıştır. [8][9][10][11][12][13][14][15] Bizde bu makalede, 32 yaşındaki hastada nadir gözüken leiomiyoadenomatoid tümör olgusunu sunduk.…”

Adenomatoid Tumor of the Uterus: An Incidental Finding

“…Cytologic features of the lesion, particularly lack of significant nuclear atypia or mitotic activity and identification of typical features as described above should assist in the recognition of this lesion. Also, Calretinin, which is strongly expressed in adenomatoid tumor, is not expressed in most of the carcinomas which might involve the myometrium, although it must be remembered that it can be expressed in certain ovarian tumors, in which case additional stains may be required if the histology features are not clear cut [10,14,15]. Adenomatoid tumors with a diffuse infiltrative growth pattern have to be distinguished from malignant lesions such as metastatic signet ring cell adenocarcinoma, epithelioid hemangioendothelioma, along with germ cell tumor or sex cord stromal tumors as told above [11].…”