Myocardial infarction with nonobstructive coronary artery disease (MINOCA) is a group of conditions that share common characteristics and is characterized by the absence of [?]50% stenosis of coronary arteries and without any evidence of atherosclerotic plaque rupture [1]. A study conducted by Waller et al. reported that 4% to 7% of all patients diagnosed with AMI, do not have underlying atherosclerotic coronary disease on autopsy or angiography [2].Coronary artery embolism is a rare and important non-atherosclerotic cause of acute myocardial infarction (AMI), and the first case of AMI secondary to coronary embolism was reported in 1856 by Rudolf Virchow and was classified initially as a precipitating factor for type-II MI, now recognized as one of the cause of MINOCA [3]. Coronary embolism (CE) is more frequently reported in infective endocarditis patients and it mainly involves the left main coronary artery system due to flow characteristics and aortic morphology [4,5]. CE may also originate from mural thrombus within the left-sided cardiac chambers, but it has rarely been reported in the literature [6]. Most cases of coronary embolism in the literature have been reported secondary to infective endocarditis, valvular heart diseases, and atrial fibrillation [7][8][9]. Here, we are reporting a case of a 74-year-old female, who had a chronic history of atrial fibrillation on anticoagulation with questionable compliance and was admitted with sepsis and takotasubo cardiomyopathy and later developed AMI secondary to coronary embolism to the left anterior descending artery.
Case History/examination:A 74-year-old female with a past medical history of atrial fibrillation on rivaroxaban with questionable compliance, type 2 diabetes, multiple cerebrovascular accidents, and suspected paranoid schizophrenia, was brought to the ED with altered mental status.On examination, her pulse was 114/min, irregularly irregular, blood pressure of 123/109 mmHg, respiratory rate of 24/min, afebrile, and was maintaining oxygen saturation of 95% at room air.
Methods:Baseline investigations showed WBC of 14.9 and urinalysis suggestive of UTI. Her Troponin level and proBNP were reported high (troponin 56 and proBNP of 16, 484). Electrocardiography (EKG) revealed atrial fibrillation with rapid ventricular response, low voltage QRS, poor R wave progression, and non-specific T wave