A case of latent primary biliary cirrhosis

Histological recurrence of autoimmune liver diseases after living‐donor liver transplantation

“…Although no donor or donor candidate had a definite diagnosis of PBC in this study, a couple of donors were found to have PBC‐compatible serology or histology. Another similar case has already been reported in LDLT, suggesting the familial occurrence of PBC 25 . Although our two LDLT were performed successfully, and the donors and recipients are alive and well, the potential risk of development of PBC in the donors should be considered.…”

Natural history of primary biliary cirrhosis

“… 14 investigated the prevalence of AMA in first‐degree relatives of PBC patients in the USA and reported that the prevalence rates of AMA in first‐degree relatives and controls were 13.1% and 1%, respectively. Most donors for living‐donor liver transplantation (LDLT) are family members, and LDLT has been reported to be associated with a higher rate of recurrent disease than cadaveric donor transplantation 15,16 . The precise importance of serum AMA during the pathogenesis of PBC needs to be ascertained.…”

“…Most donors for living-donor liver transplantation (LDLT) are family members, and LDLT has been reported to be associated with a higher rate of recurrent disease than cadaveric donor transplantation. 15,16 The precise importance of serum AMA during the pathogenesis of PBC needs to be ascertained. If serum AMA is a marker of pathogenic autoimmunity, a survey of serum AMA would be helpful in detecting latent or early PBC, especially among family members of PBC patients ( Fig.…”