A case of lactic acidosis induced by linezolid

Abstract

Discontinuation of linezolid.

Early lactic acidosis associated with linezolid therapy in paediatric patients

“…Lactic acidosis is considered a rare adverse event that was first reported in 2003 by Apodaca and Rakita [17], who described the case of a 52-year-old woman developing lactic acidosis after 11 weeks of oral linezolid therapy. Since then, several additional cases have been published [18][19][20][21][22][23], mostly in older patients [24]. Until Contou et al reported lactic acidosis occurring only 4 h after linezolid administration, it was supposed that several days' exposure (4-120 days) to linezolid was necessary for lactic acidosis to develop [24].…”

Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism

“…In addition, De Vriese et al also reported a decreased mitochondrial enzymatic activity in a patient treated with linezolid (6). Moreover, it has been recently described that the presence of A2706G and G3010A mitochondrial 16S rRNA polymorphisms could predispose to the development of linezolid-related lactic acidosis (4,11). Here, we have studied the presence of 16S rRNA polymorphisms in two liver transplant patients who developed lactic acidosis while receiving linezolid therapy.…”

“…They described two polymorphism in the mitochondrial 16S rRNA (i.e., A2706G and G3010A) of two patients that could explain a potential susceptibility to linezolid. In other studies (4,11), the presence of the A2706G polymorphism was linked to linezolidrelated lactic acidosis in two patients. Despite these evidences, it is difficult to conclude about the relationship between the presence of these polymorphisms and the susceptibility to linezolid-induced lactic acidosis due to the moderate prevalence of these polymorphisms in the general population (7).…”

“…Among the most common side reactions are gastrointestinal disturbances, followed by headache and rash. However, long-term use of this antibiotic can lead to severe toxicity, particularly myelosuppression, peripheral or optic neuropathy, serotonin syndrome (1), and lactic acidosis (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

A Triad of Linezolid Toxicity: Hypoglycemia, Lactic Acidosis, and Acute Pancreatitis

“…Linezolid, an oxazolidinone antimicrobial, has been shown to interfere with mitochondrial protein synthesis, perhaps due to structural similarities between bacterial and mitochondrial ribosomes (11). A reduction in mitochondria-derived complex IV (12, 13) impairs cellular oxidative phosphorylation and augments glycolysis.…”