A Case of Isolated Bowenoid Papulosis of the Nipple

Abstract

Bowenoid papulosis (BP) is a disease that mainly occurs in sexually active young adults. The patients present with multiple pigmented papular lesions with a verrucous surface on the anogenital area. Although extragenital BP is usually associated with concomitant genital involvement, a few cases of isolated extragenital BP have been reported. However, to our knowledge, BP of the nipple has not yet been reported in the medical literature. We report the case of a 32-year-old woman who presented with isolated extragenital BP of the nipple caused by human papillomavirus-16.

Dermoscopic and Reflectance Confocal Microscopy Findings in Extra-genital HPV16-associated Pigmented Squamous Cell Carcinoma in situ

“…Isolated HPV-associated SCCIS in the extra-genital area, without concomitant genital HPV infection, has been reported infrequently (2); such cases may present as pigmented papules or plaques, which may be difficult to differentiate from melanoma.…”

Bowenoid Papulosis With Clinical Features Resembling Condyloma Acuminata : a Case Report

“…Although this is rare, 2.6% of cases have been reported. 7,14 Lesion with longer duration, predominantly in elderly individuals, should be considered a sign of malignant transformation, surgically or laser should be done to remove the lesion. Prevention is necessary, because this STD has been shown to be associated with cervical neoplasia resulting from HPV 16.…”

A rare case of concomitant bilateral nipple and vulval condyloma accuminatum

“…BP is a cutaneous condition characterized by pigmented verrucous papules. 6 Histologically, there is papillomatosis and acanthosis of the epidermis. The epidermis also shows varying degrees of dysplasia with loss of orderly maturation of keratinocytes.…”

“…While extra-genital BP is usually accompanied by coexistent anogenital lesions, some cases of isolated extra-genital BP have been reported. 6…”

“…Skin lesions of the breast may pose a challenge to physicians because they may have a varied clinical differential diagnosis ranging from HPV warts, molluscum contagiosum to bowenoid papulosis. 5–7 These lesions may occur in isolation or may coexist with lesions on the genitalia and skin from elsewhere on the body. The association of breast malignancies and HPV is a contentious issue.…”