A case of invasive papillary breast carcinoma: Fierce façade with favorable prognosis

Abstract

Invasive papillary carcinoma of the breast is a rare, distinct variant comprising approximately less than 1-2% of all newly diagnosed cases of breast carcinoma and is usually found in postmenopausal women with a more favorable prognosis. We report an unusual case in a 45-year-old perimenopausal female who came with a complaint of lump in right breast for duration of 1 year. A simple mastectomy was undertaken for histopathological study and immunohistochemistry (IHC) which showed characteristic features of an invasive papillary breast carcinoma. We present this case in view of its rarity and to highlight this clinicopathological subtype for its good prognosis and to avoid overtreatment.

Invasive papillary carcinoma of the breast: a rare case report

“…Mammography can show a round, oval or irregular high-density mass, sometimes associated with satellite nodules, and margins are circumscribed but may be obscured or indistinct. Accompanying microcalcification or a dilated ductal pattern may be present [2]. Ultrasonic evaluation of Invasive Papillary Carcinoma reveals a hypoechoic solid mass commonly accompanied with posterior acoustic enhancement.…”

“…Of these P63 and smooth muscle, myosin is more specific. A special myoepithelial marker P63 stains the cell muscles only [2]. Genetic Features may help in distinguishing papillary carcinoma from benign lesions.…”

“…Histologically lesions are classified as papillary carcinomas having a frond-forming growth pattern supported by a fibrovascular stalk. The absence of the myoepithelial layer differentiates carcinomas from benign papillary lesions [1,2]. We report this case because of its rarity and typical imaging finding leading to the diagnosis of IPC.…”

Invasive papillary carcinoma of the breast: A case report

“…The liver function of the patient was also assessed, with results showing alkaline phosphatase at 41 U/l, total protein at 57 g/l, and albumin at 36.6 g/l, all slightly below the reference range (13). Blood cell analyses revealed a red blood cell count of 3.38x10 12 /l, hemoglobin level of 83 g/l, mean corpuscular volume of 78.5 fl and mean corpuscular hemoglobin of 24.6 pg. The white blood cell count was 4.54x10 9 /l and platelet count was 371x10 9 /l.…”

“…This definition was maintained without modification in the subsequent fifth edition of the classification (2019) (9). Currently, research on IPC is limited to case reports and small retrospective studies (2,(10)(11)(12), which has resulted in a lack of understanding of this rare tumor. Diagnosing IPC can be difficult due to a lack of in-depth knowledge and understanding, and there is currently no established standard treatment in the medical community.…”