A case of intraneural perineurioma derived from the inferior alveolar nerve that was resected by sagittal split ramus osteotomy

Abstract

Perineurioma is a tumor that originates from the proliferation of perineurial-like cells and is classified into soft tissue perineurioma, which grows on the soft tissue rather than along the nerve, and intraneural perineurioma, which develops within the nerve. Perineurioma is uncommon, and reports of its occurrence in the oral cavity area are exceedingly rare. We describe our experience with a case of intraneural perineurioma derived from the inferior alveolar nerve that developed in the mandible and was resected by sagittal split ramus osteotomy. Here, we report a summary of our experience. A 41-year-old woman visited a clinic to undergo detailed examination of the radiolucent right mandibular ramus. A biopsy was performed, and a neural tumor was diagnosed. The tumor was resected by sagittal split ramus osteotomy with the patient under general anesthesia. Histopathological diagnosis of the resected specimen definitively identified the tumor to be intraneural perineurioma. Sagittal split ramus osteotomy was extremely effective for resection of the neural tumor derived from the inferior alveolar neurovascular bundle. Postoperatively, her occlusion is stable, and she has made satisfactory progress without recurrence as of 24 months after operation. : intraneural perineurioma (神経内神経周膜腫) ， inferior alveolar nerve (下歯槽神経) ， sagittal spit ramus osteotomy (下顎枝矢状分割法) 1) 独立行政法人国立病院機構東京医療センター歯科口腔外科 (主任：大鶴 洋医長) 2) 独立行政法人国立病院機構東京医療センター臨床検査科 (主任：白石淳一科長) 1)