A Case of Intracranial Embryonal Carcinoma mimicking a HCG-producing Germinoma

一彦, 杉山; 和徳, 有田; 薫, 栗栖; 達憲, 岡村; 真一郎, 竹下; 裕尊, 今田; 正三, 吉川

doi:10.7887/jcns.9.768

Jpn J Neurosurg

2000

DOI: 10.7887/jcns.9.768

|View full text |Cite

A Case of Intracranial Embryonal Carcinoma mimicking a HCG-producing Germinoma

杉山一彦

有田和徳

栗栖薫

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2001

Publication Types

Select...

Article1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Germinoma; EC, embryonal carcinoma; T, teratoma; Y, yolk sac tumor; CC, choriocarcinoma * Biopsy; 9 partial removal; 9 total removal; # autopsy the tumor was diagnosed as E C based on morphological evidence of sheets and glands of mitotically active polygonal cells with bizarre nuclei and prominent nucleoli 11. Case 22 (HA-II/III,…”

mentioning

confidence: 99%

Morphologic features of human chorionic gonadotropin-or alphafetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning

et al. 2001

Self Cite

View full text Add to dashboard Cite

Our study of germ cell tumors (GCT) of the central nervous system (CNS) investigated the relationship between tumor histology and patient serum titers of human chorionic gonadotropin (HGC) and alpha-fetoprotein (AFP). Thirty-five patients were enrolled. Their serum titers of HCG (mlU/ml) and/or AFP (ng/ml) before initial treatment were available, as were tumor specimens obtained before the administration of adjuvant therapy. They were divided into three groups, depending on whether HCG alone (group H), AFP alone (group A), or both HCG and AFP (group HA) were detected. Each group was subdivided into three groups: patients in group I had H, A, and/or HA titers below 9.9; patients in group II/III had titers from 10.0 to 999; and those in group IV had titers of 1000 or more. Serial sections of tissue specimens were repeatedly stained, mainly with hematoxylin and eosin (H-E) stain, HCG immunostain, and AFP immunostain. There were seven patients in the H-I group and five in H-II/III. Of these 12 patients, 11 had germinomas (G) and one had an embryonal carcinoma (EC). Five patients were included in group A: one was classified as A-II/III and had a germinoma, and the remaining four patients were in A-IV and had yolk sac tumors (YST) or mixed GCT consisting mainly of YST or EC (MXGCT-YST, EC). The HA group consisted of 18 patients. Three were classified as HA-I and had germinomas; nine HA-II/III patients had T or MXGCT-T; and six HA-IV patients had choriocarcinoma (CC), YST, MXGCT-CC, or MXGCT-YST. Throughout the study, the situations for the elevated serum titers could be elucidated in only four cases (three in group A-IV and one in group HA-IV). These results led to the conclusion that serologic evaluation is superior to morphologic evaluation in diagnosing marker-producing GCTs. From a diagnostic perspective, the role of surgery is to verify the HCG- and AFP-immunonegative tissue in patients with G, T, and EC.

show abstract

mentioning

confidence: 99%

Morphologic features of human chorionic gonadotropin-or alphafetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning

et al. 2001

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A Case of Intracranial Embryonal Carcinoma mimicking a HCG-producing Germinoma

Cited by 1 publication

References 25 publications

Morphologic features of human chorionic gonadotropin-or alphafetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning

Morphologic features of human chorionic gonadotropin-or alphafetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning

Contact Info

Product

Resources

About