A case of intra-abdominal hemorrhage secondary to peliosis hepatis

Downes, Ross O.; Cambridge, Craig L.; Diggiss, Charles; Iferenta, James; Sharma, Muneesh

doi:10.1016/j.ijscr.2014.12.030

Cited by 8 publications

(10 citation statements)

References 29 publications

(47 reference statements)

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“…PH traditionally has been associated with infections including Bartonella henselae (bacillary angiomatosis), but has also been identified in lymphoplasmacytic lymphoma, Castleman's Disease, Waldenstrom's Hyperglobulinemia, Hodgkin's disease, pregnancy, renal and cardiac transplantation, as well as associated with medication exposure such as 6-thioguanine, corticosteroids, androgens, oral contraceptives and danazol [1,2]. Most patients are asymptomatic on presentation or in rare cases present with intraperitoneal hemorrhage after rupture of blood filled cysts [3]. In this case, the patient first presented with diarrhea and weight loss.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Peliosis Hepatis in a Patient with a Metastatic Neuroendocrine Tumor

Kaplan¹

2019

CSMC

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Peliosis Hepatis (PH) is a rare liver vascular abnormality notable for large dilated sinusoids within the liver parenchyma. Its mechanism is unclear but is associated with some infections and malignancies including Hodgkin's disease and lymphoplasmacytic lymphoma.Here we describe a case of a 63 years male presenting to the Emergency Department with one month of abdominal pain and diarrhea in the setting of a 60lb unintentional weight loss. Follow-up imaging and liver biopsy revealed the presence of a metastatic a well-differentiated neuroendocrine tumor metastatic to the liver and PH. From our review of the literature, this is the first case of a neuroendocrine tumor associated with PH, which warrants further study and investigation.

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Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Peliosis Hepatis in a Patient with a Metastatic Neuroendocrine Tumor

Kaplan¹

2019

CSMC

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“…It has been proposed that peliosis hepatis results from loss of the integrity of the microvasculature of the liver, either due to disruptions in the microcirculation such as alteration in local intravascular pressure or congenital malformation in the vessels. It is thought that damage to the microvasculature of liver, along with additional unknown factors, is responsible for the development of peliosis hepatis (17). An article published in 2005 proposes that peliotic lesions are venous malformations that have been created by alterations in local intravascular pressure conditions in the spleen, a similar pathogenesis to peliosis hepatis (5).…”

Section: Discussionmentioning

confidence: 99%

An Autopsy Case of Spontaneous Splenic Rupture Due to Isolated Splenic Peliosis and Review of the Literature

Prats

Aronson

2016

Academic Forensic Pathology

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Peliosis is a rare entity that is characterized by cystic or blood-filled spaces in the parenchyma of solid organs. It is most commonly seen in the spleen in patients who also have peliosis hepatis. Isolated splenic peliosis is very rare and spontaneous rupture due to splenic peliosis is even more uncommon. This diagnosis has high importance in forensic pathology as it is a rare cause of atraumatic splenic rupture. We present a case in which the diagnosis of isolated splenic peliosis with massive hemoperitoneum was made at autopsy.

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“…Esta entidad afecta el sistema reticuloendotelial, pero, su etiología no ha sido completamente establecida. Entre los múltiples factores causales, están los tratamientos farmacológicos (6-mercaptopurina, anabolizantes, azatioprina, esteroides anticonceptivos, danazol, glucocorticoides, tamoxifeno), los procesos infecciosos (endocarditis bacteriana, VIH, lepra, pielonefritis, sífilis, tuberculosis), las discrasias sanguíneas (linfoma, enfermedad de Hodgkin, metaplasia mieloide, enfermedad de Fanconi, macroglobulinemia), las neoplasias (adenocarcinoma de colon o de estómago, carcinoma hepatocelular, cáncer de páncreas, cáncer de próstata, carcinoma de células renales) y otras causas (trasplante cardíaco, hemodiálisis crónica, enfermedad de Crohn, diabetes mellitus, artritis reumatoide, lupus eritematoso sistémico e, incluso, alcoholismo) 18 .…”

Section: Púrpura Hepática (Peliosis Hepatis)unclassified

Causas inesperadas de abdomen agudo

Prieto

Carvajal²,

Santos

et al. 2016

Rev Colomb Cir

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El abdomen agudo es un síndrome abdominal doloroso, que requiere rápida valoración y tratamiento médico, endoscópico o quirúrgico. Existen varias clasificaciones y, según su etiología, puede ser traumático o no traumático; a su vez, este último puede ser de tipo obstructivo, inflamatorio o vascular. Los pacientes sometidos a cirugía por abdomen agudo presentan principalmente diagnóstico de enfermedades biliares, apendicitis y hernias de pared abdominal, pero en no pocas ocasiones, el cirujano encuentra pacientes con abdomen agudo quirúrgico de causa no clara. Por esta razón, se deben tener en cuenta enfermedades insospechadas que, en forma cada vez más frecuente, son informadas en la literatura médica, entre ellas, algunas de tipo inflamatorio, como apendicitis epiploica, torsión del epiplón y compromiso del divertículo de Meckel; obstructivo, como neoplasias y hernias internas, o vascular, como púrpura hepática (peliosis hepatis), ruptura esplénica, hemoperitoneo espontáneo y vasculitis. Se hizo una búsqueda en PubMed y Clinical Key, con las palabras claves: “causes, unexpected, and acute abdomen”, y se encontraron 44 artículos publicados en los últimos cinco años, los cuales fueron analizados identificando las principales causas inesperadas de abdomen agudo.

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A case of intra-abdominal hemorrhage secondary to peliosis hepatis

Abstract: HighlightsRare case report of a vascular lesion.Etiology/clinical features.Radiological findings.General overview of disease process.

Cited by 8 publications

References 29 publications

A Rare Presentation of Peliosis Hepatis in a Patient with a Metastatic Neuroendocrine Tumor

A Rare Presentation of Peliosis Hepatis in a Patient with a Metastatic Neuroendocrine Tumor

An Autopsy Case of Spontaneous Splenic Rupture Due to Isolated Splenic Peliosis and Review of the Literature

Causas inesperadas de abdomen agudo

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