A case of intestinal MALToma with co-existent tuberculosis and Peutz-Jeghers polyp

Srinivasan, AP; Parijatham, BO; Ganapathy, Hemalatha

doi:10.4103/0022-3859.150900

Cited by 4 publications

(3 citation statements)

References 7 publications

(7 reference statements)

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“…Overall, a solitary PJP was found in the large intestine in more than three-quarters of the patients, e.g., cecum, transverse colon, sigmoid colon, and rectum ( N = 39, 77%). Although gastric and ileal involvement was not observed in this study, cases with a solitary PJP in the stomach [8] and ileum [9] have been reported. However, to our knowledge, no patients have had a solitary PJP in the esophagus.…”

Section: Discussionmentioning

confidence: 81%

Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp

Iwamuro

Aoyama

Suzuki

et al. 2019

Gastroenterology Research and Practice

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Background. Clinical characteristics and prognosis of patients with a solitary Peutz-Jeghers polyp (PJP) have not been fully investigated. Methods. Solitary PJP was diagnosed when a single hamartomatous lesion was identified in the gastrointestinal tract of patients without mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome. We retrospectively reviewed 51 patients (32 men and 19 women) with a solitary PJP and analyzed the sex, age at diagnosis, endoscopic features, and outcomes in this patient group. The STK11/LKB1 germline mutation was not investigated in any of the patients. Results. The mean age of the 51 patients was 66.1 years. The polyp was found in the duodenum (N=10), jejunum (N=2), cecum (N=2), transverse colon (N=5), sigmoid colon (N=21), or rectum (N=11). Most of the polyps presented as a pedunculated lesion (N=40), followed by semipedunculated (N=9) and sessile (N=2) morphologies. The mean size of a solitary PJP was 15.6 mm (range: 5 to 33 mm). During a mean endoscopic follow-up period of 4.5 years (range: 0.1 to 16.1 years), no recurrence was identified. Eighteen of the enrolled patients had a history of cancer or concomitant cancer. Five patients died due to non-gastrointestinal-related causes. No additional cancer or death directly related to solitary PJP was observed. Conclusions. Solitary PJPs did not recur in this study. Although examination of the entire gastrointestinal tract using esophagogastroduodenoscopy, enteroscopy, and colonoscopy is desirable to exclude Peutz-Jeghers syndrome, follow-up endoscopy after endoscopic polyp resection may be unnecessary, once the diagnosis of a solitary PJP is made.

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Section: Discussionmentioning

confidence: 81%

Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp

Iwamuro

Aoyama

Suzuki

et al. 2019

Gastroenterology Research and Practice

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“…Additionally, it has been proposed that MALTomas arise as a result of chronic and persistent immunological activation, either of an autoimmune or infectious type [ 9 ]. A primary GI lymphoma must meet five requirements outlined by Dawson: (1) the lack of peripheral lymphadenopathy at the time of presentation, (2) the absence of enlarged mediastinal lymph nodes, (3) a normal total and differential white blood cell count, (4) the predominance of a bowel lesion at the time of laparotomy with only nearby lymph nodes clearly affected, and (5) the absence of lymphomatous involvement of the liver and spleen [ 10 ]. The invasion of the marginal zone and the diffuse dissemination of the tumor into the surrounding tissue are the histopathological characteristics of MALToma.…”

Section: Discussionmentioning

confidence: 99%

The Rare Case of Mucosa Associated Lymphoid Tissue Lymphoma in Ileum

Badwaik¹,

Gharde²,

Lamture³

et al. 2022

Cureus

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The body has mucosa-associated lymphoid tissue (MALT), with the gastrointestinal (Gl) tract having the greatest amount of it. Lymphoma may form when the cell growth in this tissue is aberrant. The small intestine is a common extranodular site of lymphoma, which is a systemic illness. Additionally, it has been proposed that MALT lymphomas (MALTomas) arise as a result of chronic and persistent immunological activation, whether of an autoimmune or infectious type. MALT lymphomas that develop in the duodenum are typically thought to be unrelated to Helicobacter pylori infection. However, some examples show that lymphoma regressed when H. pylori was removed.

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“…Recently, a case of intestinal MALToma with coexistent tuberculosis and Peutz-Jeghers polyp has been reported, where the patient had presented to the emergency with features of small bowel obstruction. [ 11 ] This emphasizes the need of a thorough clinical and laboratory workup to exclude the underlying etiology, at times multiple.…”

Section: Discussionmentioning

confidence: 99%