A Case of iLA Application in a Patient with Refractory Asthma Who Is Nonresponsive to Conventional Mechanical Ventilation - A Case Report -

Lee, Young Seok; Joo, Hyejin; Moon, Jae Young; Huh, Jin Won; Oh, Yeon‐Mok; Lim, Chae‐Man; Koh, Younsuck; Hong, Sang-Bum

doi:10.4266/kjccm.2012.27.2.108

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Currently, iLA is an effective bridge to LT in patients with ventilation-refractory hypercapnia [3,4], and is widely used to rescue the patient from reversible hypercapnic respiratory failure, including asthma [5]. The iLA uses an arterio-venous approach without a pump and with an artificial membrane for CO2 elimination, thus there is a limit to its application for treatment of severe hypoxemic and hemodynamically un-stable patients.…”

Section: Discussionmentioning

confidence: 99%

“…Pumpless extracorporeal interventional lung assist (iLA) is useful for supporting the pulmonary function in patients with severe hypercapnia and moderate hypoxia [3][4][5][6]. Here, we report on a patient with hypercapnic respiratory failure of BO after allogeneic peripheral blood stem cell transplantation (PBSCT) that was successfully overcome with iLA for the first time.…”

Section: Introductionmentioning

confidence: 99%

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Pumpless extracorporeal interventional lung assist for bronchiolitis obliterans after allogenic peripheral blood stem cell transplantation for acute lymphocytic leukemia

Park

Chung

Choi

et al. 2015

Yeungnam Univ J Med

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Bronchiolitis obliterans (BO), which is associated with graft-versus-host disease after allogenic hematopoietic stem cell transplantation, is a major obstacle to survival after bone marrow transplantation due to its gradual progress, eventually leading to respiratory failure. Pumpless extracorporeal interventional lung assist (iLA) is effective in treatment of reversible hypercapnic respiratory failure. In this paper, we present a 23year-old female patient who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) for acute lymphocytic leukemia. After 6 months, she complained of shortness of breath and was diagnosed with BO. Five months later, she developed an upper respiratory tract infection that worsened her BO and caused life-threatening hypercapnia. Since mechanical ventilation failed to eliminate CO2 effectively, iLA was applied as rescue therapy. Her hypercapnia and respiratory acidosis showed significant improvement within a few hours, and she was successfully weaned off iLA after 12 days. This is the first case report of iLA application for temporarily aggravated hypercapnia of PBSCT-associated BO followed by successful weaning. This rescue therapy should be considered in ventilator-refractory reversible hypercapnia in BO patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%