A case of IgA nephropathy with deep venous thrombosis in the mesentery and lower extremities

Hong, Tao; Zhang, Lei; Zhao, Wei; Chen, Rongquan; Xie, Min

doi:10.21037/qims.2018.11.05

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…In the latter study, the authors proved that the latter radius is the best strategy for analyzing 6 × 6-mm scans with a 1024 × 1024 size. Finally, as suggested by Chu et al 44 , the isolated regions with an equivalent diameter smaller than 24 μm were subsequently removed from the obtained binarized images, as they were presumed to represent noise 45 . Recent histopathological evidences have questioned this choice as high-quality histomorphometry has demonstrated that many spacings in the CC are even smaller that 24 μm 46 .…”

Section: Methodsmentioning

confidence: 99%

Photoreceptor alteration in intermediate age-related macular degeneration

Borrelli

Sacconi

Zuccaro

et al. 2020

Sci Rep

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The aim of this study was to analyze photoreceptor alterations occurring in eyes with intermediate age-related macular degeneration (AMD) and to investigate their associations with choriocapillaris (CC) flow. In this retrospective case–control study, we collected data from 35 eyes with intermediate AMD from 35 patients who had swept source optical coherence tomography structural and angiography imaging obtained. A control group of 35 eyes from 35 healthy subjects was included for comparison. Our main outcome measure for comparison between groups was the normalized reflectivity of en face image segmented at the ellipsoid zone (EZ) level, which was calculated to quantify the photoreceptor damage. OCTA metrics to quantify CC flow signal were also computed. These metrics were measured in a circle centered on the fovea and with a diameter of 5 mm. In intermediate AMD eyes, the macular area occupied by drusen was identified. Therefore, the EZ reflectivity and CC flow signal were separately measured in regions without drusen (“drusen-free” region). Measurements were generated using previously published algorithms. Mean ± SD age was 74.1 ± 6.8 years in the intermediate AMD group and 72.1 ± 6.0 years in the control group (p = 0.206). The normalized EZ reflectivity was 0.76 ± 0.10 in the intermediate AMD group and 0.85 ± 0.08 in the control group (p < .0001). In the “drusen-free” region, the normalized EZ reflectivity was 0.77 ± 0.10 (p < .0001 vs. healthy controls) and was positively correlated with the CC flow signal density (ρ = − 0.340 and p = 0.020). In conclusion, eyes with intermediate AMD exhibit a diffuse reduced EZ normalized reflectivity, and this reduction is correlated with CC flow signal in the regions without drusen. This study supports the concept of the damage of the unit comprised of photoreceptor, CC, and intervening tissues as an early event in AMD.

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Section: Methodsmentioning

confidence: 99%

Photoreceptor alteration in intermediate age-related macular degeneration

Borrelli

Sacconi

Zuccaro

et al. 2020

Sci Rep

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“…There are no reported cases of inflammatory-mediated SVCS in patients with IgA nephropathy, however, there are reports of thrombus formation in patients with nephrotic syndromes that lead to SVCS [ 13 ]. Previous literature is more suggestive of hypercoagulable pathogenesis to vessel occlusion rather than inflammatory stenosis in patients with IgA nephropathy [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Rheumatoid vasculitis (RV) is a vascular sequela of RA, where inflammation leads to necrosis of small and medium-sized blood vessels [ 5 ]. IgA nephropathy involves the circulation of antibodies and increases a patient’s inflammatory state, with the potential to cause autoantibody-mediated endothelial damage to vessel walls [ 6 ]. Here, we report a rare case of inflammatory SVCS highly suspected to be secondary to RA and IgA nephropathy.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Superior Vena Cava Syndrome in a Patient With Rheumatoid Arthritis and IgA Nephropathy

Moore¹,

Loichle²,

Tavakolian³

et al. 2022

Cureus

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Superior vena cava syndrome (SVCS) is a vascular condition resulting from an impaired venous return to the right atrium. The majority of SVCS cases are caused by mass effect in which extrinsic compression of the vessel leads to obstruction of blood flow. In less common cases of SVCS, thrombus formation and luminal narrowing can result in poor return through the SVC. Inflammatory causes of SVCS are even rarer and poorly documented. IgA nephropathy and rheumatoid arthritis (RA) are two autoimmune diseases with the potential to cause vasculitis, thus increasing the likelihood of intraluminal vessel occlusion. We report a rare case of SVCS in a 65-year-old female with a past medical history significant for atrial fibrillation, IgA nephropathy, chronic kidney disease stage IIIA, and RA who presented with headache, dizziness, and neck pain and swelling extending down the left upper extremity for three days. Inflammatory SVCS is uncommon and cases of SVCS secondary to RA and IgA nephropathy are underreported in the literature thus far. Our hope in presenting this case is to encourage a greater degree of suspicion for vascular complications, such as SVCS, in patients with autoimmune and inflammatory conditions.

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A case of IgA nephropathy with deep venous thrombosis in the mesentery and lower extremities

Cited by 2 publications

References 28 publications

Photoreceptor alteration in intermediate age-related macular degeneration

Photoreceptor alteration in intermediate age-related macular degeneration

A Rare Case of Superior Vena Cava Syndrome in a Patient With Rheumatoid Arthritis and IgA Nephropathy

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