A case of idiopathic GGT elevation with acute hepatitis A

Singh, Jaspreet; Jones, Geoffrey; Mahan, David C.

doi:10.4103/jfmpc.jfmpc_342_19

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Serum biochemical values ALT, AST, Tbil, Dbil, ALP, and GGT are important indexes to evaluate whether liver function is normal or not. 29–32 Our study found that the liver function indexes ALT, AST, Tbil, Dbil, ALP, and GGT were significantly up-regulated in BDL mice, indicating that hepatolithiasis promoted liver injury. It is well known that CHI3L1 and LN are important indicators for the evaluation of liver fibrosis.…”

Section: Discussionmentioning

confidence: 68%

TLR4-MyD88-NF-κB signaling pathway contributes to the progression of secondary hepatic injury and fibrosis in hepatolithiasis

Fang

Zhou

et al. 2021

Eur J Inflamm

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This paper focused on evaluating the effect of TLR4-MyD88-NF-κB signaling pathway in the progression of secondary hepatic injury and fibrosis in hepatolithiasis. The levels of inflammatory factors (IL-1β, IL-6, TNF-α) and serum biochemical values (ALT, AST, Tbil, Dbil, ALP, GGT) were detected by ELISA. IHC was used to detected the expression level of TLR4 in liver tissues of hepatolithiasis patients and mice. The pathological changes of liver tissue were observed by HE staining. The levels of MyD88, NF-κB, IκB, Laminin (LN), and chitosan enzyme 3-like protein 1 (CHI3L1) were detected by western blotting. In hepatolithiasis patients, the levels of TNF-α, IL-1β, and IL-6 were distinctly raised and proteins associated with TLR4-MyD88-NF-κB signaling pathway (such as TLR4, MyD88, NF-κB, and IκB) in liver tissues were significantly up-regulated. In Bile duct ligation (BDL) model of mice, the results showed that in addition to the significant increase of inflammatory factors, liver function indexes, and fibrosis indexes in BDL mice were also significantly up-regulated. Additionally, TLR4-MyD88-NF-κB signaling pathway was activated in BDL mice. After TLR4 knockdown in BDL mice, inflammatory factors, liver function indexes, and fibrosis indexes were significantly down-regulated. TLR4-MyD88-NF-κB signaling pathway proteins were restrained. TLR4-MyD88-NF-κB signaling pathway took part in the progression of secondary hepatic injury and fibrosis in hepatolithiasis. Inhibition of TLR4-MyD88-NF-κB signaling pathway can reduce the progression of secondary hepatic injury and fibrosis in hepatolithiasis.

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Section: Discussionmentioning

confidence: 68%

TLR4-MyD88-NF-κB signaling pathway contributes to the progression of secondary hepatic injury and fibrosis in hepatolithiasis

Fang

Zhou

et al. 2021

Eur J Inflamm

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“… 46 GGT is another liver enzyme and is involved in glutathione synthesis and catabolism, amino acid transport and detoxification. 47 , 48 Exposure to pro-oxidative factors stimulates an antioxidant response and induces the production of GGT, thereby increasing the production of glutathione. 49 , 50 An increase in GGT activity can also reflect the deposition of fat in the liver and visceral obesity, and visceral fat is associated with impaired insulin signalling in the liver, which promotes the development of NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis

Yang

et al. 2021

J Int Med Res

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Objective To evaluate the utility of Golgi protein 73 (GP73) in the diagnosis of non-alcoholic steatohepatitis (NASH) and hepatic fibrosis (HF) staging. Methods Ninety-one patients with non-alcoholic fatty liver disease (NAFLD) were allocated to NAFL (n = 46) and NASH (n = 45) groups according to their NAFLD activity score (NAS), and there were 30 healthy controls. Serum GP73 was measured by ELISA, GP73 protein expression was evaluated using immunohistochemistry, and FibroScan was used to determine liver hardness. Results The serum GP73 concentrations of the NAFL and NASH groups were significantly higher than those of controls. GP73 expression in the liver of the patients gradually progressed from absent or low to moderate or high. Serum GP73 positively correlated with liver expression, and the serum and liver GP73 of the patients positively correlated with FibroScan value and HF stage. There was a strong positive correlation of the combination of alanine aminotransferase, gamma glutamyl transferase and GP73 with NASH. The combination of serum GP73 and FibroScan value was found to predict NASH (NAS > 4) and advanced HF (stage ≥2) in patients with NAFLD using receiver operating characteristic analysis. Conclusion Serum GP73 may be useful in the diagnosis of NASH and the staging of HF.

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Association between γ-Glutamyltransferase and Head and Neck Cancer in Korean Population: A National Population-Based Study

Lee

Kim

Park

et al. 2022

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Gamma-glutamyltransferase (GGT) is positively associated with several cancer types. The objective of this study was to investigate the association between GGT and head and neck cancer (HNC) incidence in a cohort of 10 million people, considering effects of smoking and alcohol consumption. Methods: All data used in this study were obtained from the Korean National Health Insurance Service database. We analyzed subjects who underwent health check-ups in 2009 and monitored them until 2018 (n = 9,597,952). Using proportional hazards models, quartiles of GGT as independent predictors for HNC incidence were evaluated. Results: The overall incidence of HNC increased in the highest quartile (r-GPT ≥ 40 U/L) (hazards ratio [HR]: 1.452, 95% confidence interval [CI]: 1.354–1.557). Among HNC cases, the HR for hypopharyngeal cancer (HR: 2.364, 95% CI: 1.818–3.074) was significantly higher. HRs for HNC (larynx, sino-nasal, oropharynx, oral cavity, and nasopharynx, except salivary glands) were also significant. Conclusions: Elevated GGT was associated with the risk of some types of HNCs such as hypopharyngeal, laryngeal, sinonasal, oropharyngeal, oral cavity, and nasopharyngeal cancer. Impact: Results of this study have implications for etiological investigations and preventive strategies.

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A case of idiopathic GGT elevation with acute hepatitis A

Cited by 3 publications

References 9 publications

TLR4-MyD88-NF-κB signaling pathway contributes to the progression of secondary hepatic injury and fibrosis in hepatolithiasis

TLR4-MyD88-NF-κB signaling pathway contributes to the progression of secondary hepatic injury and fibrosis in hepatolithiasis

Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis

Association between γ-Glutamyltransferase and Head and Neck Cancer in Korean Population: A National Population-Based Study

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