A case of hypervascular hyperplastic nodules mimicking hepatocellular carcinoma in alcoholic liver cirrhosis

Park, Jae Eun; Kim, Byung Seok; Lee, Chang Hyeong; Choi, Jae Young; Park, Young Chan; Park, Kwan Kyu

doi:10.3350/kjhep.2009.15.2.193

Cited by 3 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This biochemical change is a diagnostic marker for alcoholic fatty liver disease in the medical population [ 57 ]. As fibrosis progresses in the liver, ALT activity commonly decreases and AST to ALT gradually increases due to ALT production decrease [ 58 ]. We observed fibrosis in the liver at 3, 6, and 9 weeks.…”

Section: Discussionmentioning

confidence: 99%

Multiple time‐dependent pathophysiological changes in a rabbit model of high‐fat diet‐induced hyperlipidemia

et al. 2023

View full text Add to dashboard Cite

High‐fat diets (HFD) adversely affect organ systems. Several studies have examined HFD‐related disorders in animals but only in a few organs and time points. Herein, we evaluated disease development with time‐dependent HFD‐induced pathological, cardiovascular, and morphological changes in rabbits with lipid metabolism similar to that in humans for 9 weeks. The body weights and waist ratio of the HFD group were higher than those in the control group. HFD significantly increased the total cholesterol, low‐density lipoprotein, high‐density lipoprotein, and phospholipid levels after 3 weeks. Liver enzyme levels increased with hepatomegaly, steatosis, and fibrosis after 3 or 6 weeks. RBCs and hemoglobin decreased, while platelets increased in the HFD group with atherosclerosis and inflammatory cell infiltration in the aorta after 6 weeks. Ejection fraction and fractional shortening values decreased in the HFD group after 9 weeks. Creatinine increased with glomerulosclerosis in the kidneys of the HFD groups after 3 weeks, indicating renal dysfunction. Lipid accumulation was found in the pancreas after 9 weeks. Lipid accumulation and hypertrophy were observed in the adrenal glands after 3 weeks. Overall, our findings provide global reference data on the time‐dependent effects of HFD on the body and may serve as a guide for future HFD risk prevention.

show abstract

Section: Discussionmentioning

confidence: 99%

Multiple time‐dependent pathophysiological changes in a rabbit model of high‐fat diet‐induced hyperlipidemia

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Park et al 3 reported a case of HHN in alcoholic liver cirrhosis, in which the nodules showed no change in size and number after four months from the initial diagnosis. In the case reported herein, 3D CT was performed after six months, and the follow-up 3D CT showed that the nodules had the same sizes and numbers.…”

Section: Introductionmentioning

confidence: 99%

A Case of Multiple Hypervascular Hyperplastic Liver Nodules in a Patient with No History of Alcohol Abuse or Chronic Liver Diseases

Joo

Park

Rhee

et al. 2015

Korean J Gastroenterol

View full text Add to dashboard Cite

Up-to-date imaging modalities such as three-dimensional dynamic contrast-enhanced CT (3D CT) and MRI may contribute to detection of hypervascular nodules in the liver. Nevertheless, distinguishing a malignancy such as hepatocellular carcinoma from benign hypervascular hyperplastic nodules (HHN) based on the radiological findings is sometimes difficult. Multiple incidental liver masses were detected via abdominal ultrasonography (US) in a 65-year-old male patient. He had no history of alcohol intake and no remarkable past medical history or relevant family history, and his physical examination results and laboratory findings were normal. 3D CT and MRI showed numerous enhanced nodules with hypervascularity during the arterial phase. After US guided liver biopsy, the pathological diagnosis was HHN. To date, several cases of HHN have been reported in patients with chronic alcoholic liver disease or cirrhosis. Herein, we report on a case of HHN in a patient with no history of alcoholic liver disease or cirrhosis. (Korean J Gastroenterol 2015;65:321-325)

show abstract

“…In South Korea, liver cancer ranks second in terms of crude death rate, imposing the highest economic burden among all cancer types. 1 2 3 The Korean Liver Cancer Association (KLCA), formerly known as the Korean Liver Cancer Study Group (KLCSG), and the National Cancer Center (NCC) Korea initially issued practice guidelines for managing hepatocellular carcinoma (HCC) in 2003, 4 subsequently revising them in 2009, 5 2014, 6 and 2018. 7 Over time, advancements in research and therapies have accumulated, prompting a recent revision of the guidelines to incorporate the latest research findings, novel therapies, and expert opinions.…”

mentioning

confidence: 99%

Recent Hepatocellular Carcinoma Managements in Korea: Focus on the Updated Guidelines in 2022

Cho,

Kim,

Lim

2024

Digestive Disease Interventions

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) stands as a significant contributor to mortality globally, notably in countries like Korea. In an endeavor to offer pertinent guidance for the clinical management of HCC patients, the Korean Liver Cancer Association and National Cancer Center (KLCA-NCC) Korea Practice Guideline Revision Committee recently updated the practice guidelines for HCC management. Nonetheless, disparities exist between these guidelines and the practical aspects of clinical care due to various factors. This review aims to delineate key recommendations from the 2022 iteration of the practice guidelines and present the real-world clinical landscape in Korea. Additionally, a discourse on the necessary initiatives to narrow down the divide between practice guidelines and actual clinical implementation will be provided.

show abstract

A case of hypervascular hyperplastic nodules mimicking hepatocellular carcinoma in alcoholic liver cirrhosis

Cited by 3 publications

References 14 publications

Multiple time‐dependent pathophysiological changes in a rabbit model of high‐fat diet‐induced hyperlipidemia

Multiple time‐dependent pathophysiological changes in a rabbit model of high‐fat diet‐induced hyperlipidemia

A Case of Multiple Hypervascular Hyperplastic Liver Nodules in a Patient with No History of Alcohol Abuse or Chronic Liver Diseases

Recent Hepatocellular Carcinoma Managements in Korea: Focus on the Updated Guidelines in 2022

Contact Info

Product

Resources

About