A case of hypertrophic feline muscular dystrophy in a Belgian domestic shorthair cat

Soens, Iris Van; Mols, N.; Meervenne, Sofie Van; Bilzer, Thomas; Waelbers, Tim; Binst, Dominique; Tshamala, Mulenda; Verhaeghe, A; Saunders, Jimmy; Ham, Luc Van

doi:10.21825/vdt.87505

Cited by 2 publications

(5 citation statements)

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“…An absence of dystrophin in dogs has been associated with diffuse muscle atrophy, except for specific muscles that hypertrophy (ie, semimembranosus, semitendinosus and tongue muscles) and with generalised muscle hypertrophy in cats 1 2 4–6 8 9 11. Clinical signs in cats have been recognised as early as five months3 or as late as two years of age 13. The most commonly reported clinical signs in this species are hypertrophy of the skeletal muscles and stilted gait 2 3 13.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical signs in cats have been recognised as early as five months3 or as late as two years of age 13. The most commonly reported clinical signs in this species are hypertrophy of the skeletal muscles and stilted gait 2 3 13. Only in the case described by Gambino and others2 was the main complaint regurgitation.…”

Section: Discussionmentioning

confidence: 99%

“…Life‐threatening complications such as acute kidney injury and peracute rhabdomyolysis can develop. Acute kidney injury may result due to dehydration and hyperosmolality secondary to the regurgitation and dysphagia 13. In addition, it is hypothesised that cats with DDMD have increased sarcoplasmic reticulum membrane sensitivity to volatile anaesthetics, which may result in rhabdomyolysis 18.…”

Section: Discussionmentioning

confidence: 99%

“…Limited information exists regarding the use of corticosteroids in feline patients, with no evidence of improvement of quality of life or life expectancy. In the case reported by Soens,13 treatment with prednisolone was instituted for a total of five months, and the cat lived for a further seven months until regurgitation developed. A trial with prednisolone was discussed with the owners in the present case; however, after discussing the above evidence, this was declined and humane euthanasia was elected.…”

Section: Discussionmentioning

confidence: 99%

“…No specific treatment is available for DDMD, and the general prognosis is poor 2 4 13. Life‐threatening complications such as acute kidney injury and peracute rhabdomyolysis can develop.…”

Section: Discussionmentioning

confidence: 99%

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Unusual clinical presentation of dystrophin‐deficient feline muscular dystrophy in the UK

Eiras-Diaz¹,

Prisco

Paciello

et al. 2020

Vet Record Case Reports

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An eight-month-old, male, neutered, domestic short hair cat was presented for further investigation of white granuloma-like lesions on the tongue and recent onset regurgitation. The owner reported that the cat had an ‘unusual’ gait. Moderate increases in alanine aminotransferase, aspartate aminostransferase and markedly elevated creatine kinase were present. Thoracic radiographs revealed moderate-to-severe oesophageal impaction, cardiomegaly and an irregular appearance of the diaphragm. Endoscopy revealed a distended oesophagus with accumulation of ingesta. Difficulties were encountered when passing the endoscope through the cardia. Histology of the white granuloma-like lesions were pathognomonic of calcinosis circumscripta. These features raised the suspicion of feline muscular dystrophy. Muscle biopsies and electromyography were declined, and the patient was euthanased. Postmortem examination, histopathology and immunohistochemistry were suggestive of dystrophin-deficient muscular dystrophy (DDMD). This case emphasises the importance of including DDMD as a differential diagnosis for regurgitation and lingual calcinosis circumscripta in cats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Unusual clinical presentation of dystrophin‐deficient feline muscular dystrophy in the UK

Eiras-Diaz¹,

Prisco

Paciello

et al. 2020

Vet Record Case Reports

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Clinical aspects, food management, and clinical evolution of a cat with hypertrophic muscular dystrophy

et al. 2022

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Hypertrophic feline muscular dystrophy (HFMD), rarely reported in the literature, is a disease caused by a hereditary recessive dystrophin deficiency linked to the X chromosome, mainly affecting young male cats. Here, we presented the clinical aspects, food management, and clinical evolution of a seven-year-old mixed-breed cat diagnosed with HFMD, having a primary history of progressive tongue protrusion.

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A case of hypertrophic feline muscular dystrophy in a Belgian domestic shorthair cat

Cited by 2 publications

References 0 publications

Unusual clinical presentation of dystrophin‐deficient feline muscular dystrophy in the UK

Unusual clinical presentation of dystrophin‐deficient feline muscular dystrophy in the UK

Clinical aspects, food management, and clinical evolution of a cat with hypertrophic muscular dystrophy

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