A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation

Oishi, Masahiro; Yagi, T.; Urushihara, Naoto; Takakura, Norihisa; Inagaki, Masaru; Shinmoto, Hiroshi; Mastukawa, H; Inoue, Takuya; Oda, Shinsuke; Tanaka, Noriaki

doi:10.1016/s0041-1345(00)01645-6

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…These seven cases underwent liver or renal transplantation. Except for one Caucasian, and one South American, others were Asians . It seems that Asians are more susceptible to this entity.…”

Section: Discussionmentioning

confidence: 89%

Clinical analysis of hyperkalemic renal tubular acidosis caused by calcineurin inhibitors in solid organ transplant recipients

Lin

Mou

et al. 2016

J Clin Pharm Ther

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Section: Discussionmentioning

confidence: 89%

Clinical analysis of hyperkalemic renal tubular acidosis caused by calcineurin inhibitors in solid organ transplant recipients

Lin

Mou

et al. 2016

J Clin Pharm Ther

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“…An underlying slight tubular damage related to the past history of WD was also considered as a triggering factor. Although tacrolimus related nephrotoxicity has been well‐demonstrated (1, 2, 12), tacrolimus induced tubular dysfunction is reported very rarely and almost exclusively as distal RTA (13, 14). To our knowledge, there is only one case which describes proximal RTA secondary to tacrolimus in the literature (15).…”

Section: Discussionmentioning

confidence: 99%

Renal Fanconi syndrome and myopathy after liver transplantation: Drug‐related mitochondrial cytopathy?

Bayrakçı¹,

Baskın²,

Özçay³

et al. 2008

Pediatric Transplantation

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Advances in the field of transplantation provide a better quality of life and allow more favorable conditions for growth and development in children. However, combinations of different therapeutic regimens require consideration of potential adverse reactions. We describe a 15-yr-old girl who had orthotopic liver transplantation because of Wilson's disease. Tacrolimus, MMF, and steroids were given as immunosuppressant. Lamivudine was added because of de nova hepatitis B infection during her follow-up. Three yr after transplantation she developed renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacrolimus was suspected to be the cause of late post-transplant renal acidosis and was replaced by sirolimus, acidosis, and electrolyte imbalance got worse. Proximal muscle weakness has developed during her follow-up. Fanconi syndrome, as well as myopathy, is well recognized in patients with mitochondrial disorders and caused by depletion of mtDNA. We suggest that our patient's tubular dysfunction and myopathy may have resulted from mitochondrial dysfunction which is triggered by tacrolimus and augmented by lamivudine.

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“…). However, maintenance of a high tacrolimus trough level led to renal tubular acidosis, a dose‐dependent complication …”

Section: Discussionmentioning

confidence: 99%

First successful case of simultaneous liver and kidney transplantation for patients with chronic liver and renal failure in Japan

Yagi

Nobuoka

Shinoura

et al. 2013

Hepatology Research

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Establishment of a preferential liver allocation rule for simultaneous liver and kidney transplantation (SLK) and revisions of laws regarding organ transplants from deceased donors have paved the way for SLK in Japan. Very few cases of SLK have been attempted in Japan, and no such recipients have survived for longer than 40 days. The present report describes a case of a 50-year-old woman who had undergone living donor liver transplantation at the age of 38 years for management of post-partum liver failure. After the first transplant surgery, she developed hepatic vein stenosis and severe hypersplenism requiring splenectomy. She was then initiated on hemodialysis (HD) due to the deterioration of renal function after insertion of a hepatic vein stent. She was listed as a candidate for SLK in 2011 because she required frequent plasma exchange for hepatic coma. When her Model for End-stage Liver Disease score reached 46, the new liver was donated 46 days after registration. The reduced trisegment liver and the kidney grafts were simultaneously transplanted under veno-venous bypass and intraoperative HD. The hepatic artery was reconstructed prior to portal reconstruction in order to shorten anhepatic time. Although she developed subcapsular bleeding caused by hepatic contusion on the next day, subsequent hemostasis was obtained by transcatheter embolization. Thereafter, her recovery was uneventful, except for mild rejection and renal tubular acidosis of the kidney graft. This case highlights the need to establish Japanese criteria for SLK.

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A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation

Cited by 11 publications

References 3 publications

Clinical analysis of hyperkalemic renal tubular acidosis caused by calcineurin inhibitors in solid organ transplant recipients

Clinical analysis of hyperkalemic renal tubular acidosis caused by calcineurin inhibitors in solid organ transplant recipients

Renal Fanconi syndrome and myopathy after liver transplantation: Drug‐related mitochondrial cytopathy?

First successful case of simultaneous liver and kidney transplantation for patients with chronic liver and renal failure in Japan

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