A case of HIV-1 slow seroconversion: diagnostic implications

Pollett, Simon; Wienholt, Louise; Lee, F; Adelstein, Stephen; MacLeod, Colin; Chen, R F; Garsia, Roger

doi:10.1177/0956462412472457

Cited by 1 publication

(1 citation statement)

References 7 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important to recognize that WPs are estimates and that there is considerable individual variation with some individuals having shorter or longer than average WPs. Pollett et al.’s 46 example of a 21-month time-to seroconversion in a 30-year-old woman is an excellent example of how variable WPs can be. Therefore, practitioners using the table of probabilities to counsel their patients should do so with this caveat.…”

Section: Discussionmentioning

confidence: 99%

Probability of a false-negative HIV antibody test result during the window period: a tool for pre- and post-test counselling

et al. 2014

View full text Add to dashboard Cite

Failure to understand the risk of false-negative HIV test results during the window period results in anxiety. Patients typically want accurate test results as soon as possible while clinicians prefer to wait until the probability of a false-negative is virtually nil. This review summarizes the median window periods for third-generation antibody and fourth-generation HIV tests and provides the probability of a false-negative result for various days post-exposure. Data were extracted from published seroconversion panels. A 10-day eclipse period was used to estimate days from infection to first detection of HIV RNA. Median (interquartile range) days to seroconversion were calculated and probabilities of a false-negative result at various time periods post-exposure are reported. The median (interquartile range) window period for third-generation tests was 22 days (19-25) and 18 days (16-24) for fourth-generation tests. The probability of a false-negative result is 0.01 at 80 days' post-exposure for third-generation tests and at 42 days for fourth-generation tests. The table of probabilities of falsely-negative HIV test results may be useful during pre- and post-test HIV counselling to inform co-decision making regarding the ideal time to test for HIV.

show abstract

Section: Discussionmentioning

confidence: 99%