A case of heterotopic pregnancy after clomiphene-induced ovulation

Alqahtani, Hanoof Ali

doi:10.1177/2050313x19873794

Cited by 5 publications

(6 citation statements)

References 15 publications

(21 reference statements)

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“…Furthermore, ovarian stimulation can lead to superfetation, although it is extremely rare [ 10 ]. However, information about the association between CC and HP is limited and mainly restricted to case reports [ 6 , 7 ]. As far as we know, there is no association between the dosage, and duration of CC in women suffering from HP after using CC [ 7 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Heterotopic pregnancy with superfetation following ovarian stimulation: A case report

Channiss,

Tahle,

Sabouni

et al. 2023

Case Reports in Women's Health

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Section: Discussionmentioning

confidence: 99%

“…Ovarian stimulation is one of the methods used to promote conception in infertile women [ 5 ]. However, there is no clear information about ovarian stimulation as a risk factor for HP, with the literature consisting of cases only [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Heterotopic pregnancy with superfetation following ovarian stimulation: A case report

Channiss,

Tahle,

Sabouni

et al. 2023

Case Reports in Women's Health

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“…Heterotopic pregnancy (HP) is a condition in which both intrauterine and extrauterine pregnancies occur simultaneously [16]. It is rare in spontaneous pregnancy (incidence rate, 1 in 10 000-50 000), but is relatively common (0.3-1%) in pregnancies that arise from assisted conception [17,18].…”

Section: Discussionmentioning

confidence: 99%

Use of Laparoscopic Slip Knot with Purse-String Suture in Surgical Management of Unruptured Heterotopic Interstitial Pregnancies

et al. 2020

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The aim of this study was to investigate the advantages and disadvantages of using laparoscopic slip knot with purse-string suture technique in the surgical management of unruptured heterotopic interstitial pregnancies compared with other surgical strategies. Material/Methods:We retrospectively analyzed data on 13 patients with unruptured heterotopic interstitial pregnancies who underwent laparoscopy in our hospital between May 2012 and August 2018. The control group consisted of 10 patients who underwent cornual resection or cornuostomy with conventional sutures and knots. The study group consisted of 3 patients whose surgical plans involved use of the slip knot with purse-string suture technique followed by cornuostomy. We evaluated the surgical records and video to comparatively analyze their operation duration, intraoperative blood loss, and pregnancy outcomes. Results:The average volume of intraoperative blood loss was 76.67±25 ml in the study group and 215.00±110 ml in the control group. On average, the intraoperative blood loss volume in the study group was 138 ml less than in the control group and the difference was statistically significant (P<0.05). There was no statistically significant difference in the live birth rate and operation time between the 2 groups (P>0.05). The duration of hemostasis in the study group was 11 min shorter than in the control group, while the duration of cornual electrocoagulation in the study group was 18.5 s shorter. Both groups achieved thorough hemostasis without the help of vasopressin and avoided use of embryo-killing drugs such as methotrexate. Neither group required second surgery or developed postoperative complications such as uterus rupture or persistent ectopic pregnancy. Conclusions:This strategy is safe and reliable for gestational sac clearance while simultaneously preventing any potential harm to the intrauterine embryo. It is particularly suitable for unruptured HIP patients who have a strong desire to preserve their intrauterine embryos.

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“…A heterotopic pregnancy (HP) signifies the simultaneous occurrence of an extra-uterine and an intrauterine pregnancy (IUP). The occurrence is very rare with spontaneous pregnancies, estimated to be about 1:30,000 pregnancies [ 12 , 13 ]. Heterotopic pregnancies have a higher incidence of about 1:3900 pregnancies with assisted reproduction technologies (ART) such as in-vitro fertilization (IVF) and gamete intra-fallopian transfer (GIFT) [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Heterotopic pregnancies have a higher incidence of about 1:3900 pregnancies with assisted reproduction technologies (ART) such as in-vitro fertilization (IVF) and gamete intra-fallopian transfer (GIFT) [ 13 , 14 ]. The use of clomiphene citrate for ovulation induction could also increase the incidence [ 12 ]. Other risk factors include tubal damage from previous pelvic inflammatory disease (PID), history of ectopic pregnancy, miscarriage and ovarian hyper-stimulation syndrome [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Concurrent ruptured spontaneous heterotopic pregnancy and ruptured appendix with delayed presentation in the first trimester: a case report

Murewanhema¹,

Madombi²,

Hlathswayo³

et al. 2020

Pan Afr Med J

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Acute appendicitis is the commonest non-gynaecological surgical emergency in pregnancy. However, the concurrent occurrence of acute appendicitis with a heterotopic pregnancy is a rare event and presents diagnostic challenges to unsuspecting clinicians and sonographers. We present a case of a woman who had a heterotopic pregnancy and was noted to have a gangrenous appendicitis at laparotomy, illustrating how a diagnosis of acute appendicitis could easily be missed in pregnancy. We report the case of a 34-year-old woman in the first trimester of pregnancy who had a missed diagnosis of acute appendicitis after she had complained of vague abdominal symptoms for three weeks. She presented to a gynaecologist with vaginal bleeding for three days and was noted to have a heterotopic pregnancy on ultrasound scan. At laparotomy, she was noted to have a gangrenous appendicitis with pyoperitoneum concurrent with a ruptured left fimbrial ectopic pregnancy. Left salpingectomy and saline lavage were done and she had uneventful post-operative recovery. Unsuspecting clinicians, in patients without risk factors, can miss both heterotopic pregnancy and acute appendicitis. As assisted reproductive techniques become widespread, the possibility of heterotopic pregnancies must always be considered and any patient who presents with vague abdominal symptoms must be suspected to have the possibility of acute appendicitis. Because of the unreliability of laboratory investigations and clinical predictive scores in pregnancy, sonographers must be specifically asked to scan for heterotopic pregnancy and appendicitis in suspected cases.

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A case of heterotopic pregnancy after clomiphene-induced ovulation

Cited by 5 publications

References 15 publications

Heterotopic pregnancy with superfetation following ovarian stimulation: A case report

Heterotopic pregnancy with superfetation following ovarian stimulation: A case report

Use of Laparoscopic Slip Knot with Purse-String Suture in Surgical Management of Unruptured Heterotopic Interstitial Pregnancies

Concurrent ruptured spontaneous heterotopic pregnancy and ruptured appendix with delayed presentation in the first trimester: a case report

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