A case of HER-2(+) squamous cell breast carcinoma: An unusual presentation of an unusual clinical entity

Karamouzis, Michalis V.; Fida, Ania; Apostolikas, N.; Rigatos, G.

doi:10.1016/j.ejso.2006.05.008

Cited by 17 publications

(18 citation statements)

References 5 publications

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“…The negativity of the tumor to estrogen and progestin receptors -as in our case -is in accordance with what was described by Behranwala et al (7). As to the overexpression of HER2, Karamouzis et al (8) have described the only case reported in literature. Metaplastic breast carcinoma has an aggressive behavior and a poorer prognosis in comparison with invasive ductal carcinoma, both in general and with specific reference to triple negative carcinoma (3).…”

Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L Isupporting

confidence: 80%

“…The therapeutic approach is complicated by negative estrogen and progesterone receptors, as well as by HER2/neu negativity (triple negative breast cancer). A unanimous agreement among oncologists on standardized treatment of this carcinoma variant has not yet been reached (7,8 clinical practice © C I C E d i z i o n i I n t e r n a z i o n a l i…”

Section: Introductionmentioning

confidence: 99%

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Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma

Punzo¹

2017

GHIR

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Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L Isupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma

Punzo¹

2017

GHIR

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“…[3][4][5][6]10] No specific clinical or radiological findings of squamous cell carcinoma of the breast have been described. [3,4,10] Squamous cell carcinoma of the breast predominantly affects post-menopausal women [4] but a few patients in their gestational or lactating period have also been reported.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Although its histogenesis is unclear, some authors suggest it may originate from complete metaplasia of ductal epithelium. [1,3,4,14] Development of SCC from metaplastic epithelium can also be considered as a complication of chronic breast inflammation, for example due to the presence of breast implants.…”

Section: Discussionmentioning

confidence: 99%

“…It may have been associated with DCIS or squamous metaplasia of ductal epithelium at the periphery of the invasive carcinoma, [2,4,6,12,17] Estrogen and progesterone receptors are almost always reported to be negative. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] c-erbB-2 is also usually not overexpressed or amplified but some cases with c-erbB-2 positivity have been seen. [3,6,18] Our patient's tru-cut biopsy specimen which was taken before the chemotherapy contained small tumoral areas with infiltrative cell groups having no keratin formation.…”

Section: An Invasive Tumor With Cells Containing Eosinophilic Cytoplamentioning

confidence: 99%

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Primary Squamous Cell Carcinoma Of The Breast: A Case Report And Immunohistochemical Features For Differential Diagnosis

Temız¹,

Kandiloğlu²,

Şimşek³

et al. 2008

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Primary squamous cell carcinoma (SCC) of the breast is a rare tumor classified as one of the metaplastic carcinomas of the breast. Its incidence is less than 0.1% of all ductal carcinomas. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Its clinical features and radiological appearances are not specific. [3] We present a 68-year-old postmenopausal woman with a rapidly growing right breast mass diagnosed with primary SCC of the breast. We have discussed immunohistochemical features of this rare tumor with respect to its differential diagnosis from invasive ductal Sağ memesinde hızlı büyüyen kitle yakınmasıyla başvuran 68 yaşında postmenopozal kadın hastaya tru-cut biyopsisi, lezyonun infiltratif yapısı ve immunohistokimyasal olarak c-erbB-2 (HER2/neu) ve progesteron reseptör pozitifliğine dayanarak "invaziv duktal karsinom" tanısı kondu. Hasta dört kür kemoterapiye (adriyamisin ve siklofosfamid) kısmi yanıt verdi. Kemoterapi sonrası modifiye radikal mastektomi ve aksiller lenf nodu diseksiyonu (level III) uygulandı. Makroskopik olarak üst iç ve dış kadranda 5 cm çaplı, kirli beyaz, solid, düzensiz sınırlı, merkezi kısmı nekrotik ve hemorajik tümör saptandı. Mikroskopik olarak kötü diferansiye skuamöz hücreli karsinom (SCC) niteliğindeki tümör çevresinde skuamöz metaplazili intraduktal epitelial hiperplazi ve multipl küçük SCC odakları gözlendi. Tümör, kemoterapiye bağlı regresyonu yansıtan nekrotik, hemorajik ve fibrotik alanlar içermekte idi. Deri tutulumu izlenmedi. İmmunohistokimyasal olarak tümörde CK7, CK8, CK19, HMW-CK ve E-cadherin diffüz, CEA fokal pozitifti. Östrojen ve progesteron reseptörleri ve c-erbB-2 negatifti. Materyalden ayıklanan 20 lenf nodundan beşi metastatikti. Klinik olartak skuamöz hücreli karsinomun gelişebileceği diğer organlar tarandı ve başka bir yerde herhangi bir tümör görülmedi. Operasyon sonrası oral kemoterapi (kapesitabin) alan hasta, bir yıldır sağlıklı bir şekilde yaşamını sürdürmektedir.Anahtar sözcükler: Primer skuamöz hücreli karsinom; meme; immunohistokimya; ayırıcı tanı.We present a 68-year-old postmenopausal woman with a rapidly growing right breast mass. It was diagnosed as "invasive ductal carcinoma" on tru-cut biopsy owing to infiltrative pattern and c-erbB-2 (HER2/neu) and progesterone receptor positivities. Partial response was obtained after four cure chemotherapy (adriamycin and cyclophosphamide). Then, she underwent a modified radical mastectomy with axillary lymph node dissection (level III). Grossly, a white-tan, solid, ill-defined tumor with 5 cm diameter located in the upper inner and outer quadrant of the breast was detected. Central portion of the tumor showed necrotic and hemorrhagic changes. Microscopic examination revealed poorly differentiated squamous cell carcinoma (SCC) having intraductal epithelial hyperplasia with squamous cell metaplasia and multiple small tumor foci at the periphery. The tumor had patchy necrotic, hemorrhagic and fibrotic areas representing regressive changes due to chemotherapy effect. Immunohistochemically, the t...

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Squamous cell carcinoma of the breast

et al. 2009

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A case of HER-2(+) squamous cell breast carcinoma: An unusual presentation of an unusual clinical entity

Cited by 17 publications

References 5 publications

Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma

Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma

Primary Squamous Cell Carcinoma Of The Breast: A Case Report And Immunohistochemical Features For Differential Diagnosis

Squamous cell carcinoma of the breast

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