A case of hepatocellular carcinoma associated with HCV antibody-positive primary biliary cirrhosis, treated with established surgical resection.

祐二, 矢野; Yamauchi, Yuji; Kawatoko, Toshiharu; 利晴, 川床; Fujishima, Masatoshi; 正敏, 藤島; Murakami, Takashi; 孝, 松股; 親生, 安永; Yasunaga, Chikao; 克夫, 居石; Sueishi, Katsuo

doi:10.2957/kanzo.34.723

Cited by 3 publications

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“…5 To the best of our knowledge, there were 22 case reports of hepatectomy for HCC in PBC patients in the English-language (14 cases) and Japanese studies (eight cases) that were published during the same period. 3,4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19] The definition of HCC in PBC patients in the published work review was consistent with our definition.…”

Section: Methodsmentioning

confidence: 82%

“…The indication of operation in PBC patients with HCC was the same as that of viral hepatitis patients with HCC described elsewhere . To the best of our knowledge, there were 22 case reports of hepatectomy for HCC in PBC patients in the English‐language (14 cases) and Japanese studies (eight cases) that were published during the same period . The definition of HCC in PBC patients in the published work review was consistent with our definition.…”

Section: Methodsmentioning

confidence: 99%

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Clinical significance of hepatectomy for primary biliary cirrhosis patients with hepatocellular carcinoma: Report of a single center case series and review of the published work

Sasaki

Matsuda

Ohkura

et al. 2013

Hepatology Research

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Section: Methodsmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Clinical significance of hepatectomy for primary biliary cirrhosis patients with hepatocellular carcinoma: Report of a single center case series and review of the published work

Sasaki

Matsuda

Ohkura

et al. 2013

Hepatology Research

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Hepatocellular carcinoma associated with precirrhotic primary biliary cirrhosis successfully treated by a right hepatic lobectomy: Report of a case

et al. 1996

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We report herein the case of a 69-year-old woman in whom hepatocellular carcinoma (HCC) arising in the precirrhotic phase of primary biliary cirrhosis (PBC) was successfully managed by a right hepatic lobectomy. The patient, who had never received a blood transfusion, had a 4-year history of asymptomatic PBC of Scheuer's histological classification stage II. Abdominal computed tomography (CT) revealed a mass measuring 4.0 cm in the right hepatic lobe, and a right hepatic lobectomy was performed in consideration of her good liver function and the deep location of the tumor in the right lobe. The patient has remained well without any evidence of recurrent disease for 4 years since her operation. A review of the literature revealed only two cases of successful partial hepatectomy, but none of major hepatectomy. Most of the reported cases had been treated with transcatheter arterial embolization (TAE) and were associated with poor survival. Our experience of this patient indicates the potential value of hepatectomy as an alternative to TAE in selected patients with resectable disease and good hepatic function.

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Right hepatic lobectomy for hepatocellular carcinoma which developed in primary biliary cirrhosis: Report of a case

et al. 1999

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The case of a 74-year-old female patient who underwent a right hepatic lobectomy for hepatocellular carcinoma (HCC) which developed in primary biliary cirrhosis (PBC) is reported herein. During a follow-up examination for Parkinson's disease, an elevation of hepatobiliary tract-related enzymes and alpha-fetoprotein was uncovered. Diagnostic imagings showed a hypervascular, solitary, and encapsulated tumor measuring about 7 cm in diameter located mainly in the posterior segment. Positive antimitochondrial and antinuclear antibodies and a preoperative liver biopsy strongly suggested well differentiated HCC developed in PBC (Scheuer's classification stage II). Since the natural prognosis of PBC estimated by the Mayo risk score was fairly good and the liver function indicated sufficient tolerance for major hepatic resection, and preoperative computed tomography (CT) volumetry showed the atrophy of the right hepatic lobe, a right hepatic lobectomy was performed. A pathological examination revealed well encapsulated, moderately differentiated HCC with, in part, well-differentiated HCC in the tumor and stage II PBC in the noncancerous region. CT volumetry performed at postoperative day 14 showed a 146% enlargement of the remnant liver. An early detection of HCC and PBC by strict screening would prevent a limitation of surgical therapy due to a deteriorated liver function.

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A case of hepatocellular carcinoma associated with HCV antibody-positive primary biliary cirrhosis, treated with established surgical resection.

Cited by 3 publications

References 0 publications

Clinical significance of hepatectomy for primary biliary cirrhosis patients with hepatocellular carcinoma: Report of a single center case series and review of the published work

Clinical significance of hepatectomy for primary biliary cirrhosis patients with hepatocellular carcinoma: Report of a single center case series and review of the published work

Hepatocellular carcinoma associated with precirrhotic primary biliary cirrhosis successfully treated by a right hepatic lobectomy: Report of a case

Right hepatic lobectomy for hepatocellular carcinoma which developed in primary biliary cirrhosis: Report of a case

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