A case of guilt by association: Water bug bite incriminated in M. ulcerans infection

Marion, Estelle; Chauty, Annick; Yeramian, Edouard; Babonneau, Jérèmie; Kempf, Marie; Marsollier, Laurent

doi:10.1016/j.ijmyco.2014.01.004

Cited by 18 publications

(17 citation statements)

References 19 publications

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“…Buruli ulcer was declared an emerging skin disease of public health concern by the World Health Organization (WHO) in 1998. Epidemiological studies show that this mycobacteriosis is most common in populations living near rivers, swamps and wetlands [1] , [2] , [3] , while the role of aquatic insects or mosquitoes as reservoirs and vectors of M. ulcerans has been proposed but remains controversial [4] , [5] , [6] , [7] , [8] , [9] , [10] . Since 2004, the WHO has recommended a daily treatment of rifampin and streptomycin for 8 weeks as a first line treatment [11] .…”

Section: Introductionmentioning

confidence: 99%

Buruli Ulcer in South Western Nigeria: A Retrospective Cohort Study of Patients Treated in Benin

Marion

Carolan²,

Adeye³

et al. 2015

PLoS Negl Trop Dis

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Section: Introductionmentioning

confidence: 99%

Buruli Ulcer in South Western Nigeria: A Retrospective Cohort Study of Patients Treated in Benin

Marion

Carolan²,

Adeye³

et al. 2015

PLoS Negl Trop Dis

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“…ulcerans in the aquatic environment primarily infects humans via existing minor skin trauma but could be inoculated mechanically by insect vectors through either infected arthropod saliva or transfer of M. ulcerans on the skin surface into the bite wound. However, except perhaps for sporadic cases [32], evidence for a vector role for biting aquatic bugs (or mosquitoes [103]) in BU transmission in nature is weak [23]. flight.…”

Section: Discussionmentioning

confidence: 99%

Aquatic Hemiptera in Southwest Cameroon: Biodiversity of Potential Reservoirs of <em>Mycobacterium ulcerans</em> and Multiple <em>Wolbachia</em> Sequence Types Revealed by Metagenomics

Esemu¹,

Dong²,

Kfusi³

et al. 2019

Preprint

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Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical disease associated with freshwater habitats. A variety of limnic organisms harbor this pathogen, including aquatic bugs (Hemiptera: Heteroptera), which have been hypothesized to be epidemiologically important reservoirs. Aquatic Hemiptera exhibit high levels of diversity in the tropics, but species identification remains challenging. In this study, we collected aquatic bugs from emerging foci of BU in the Southwest Region of Cameroon, which were identified using morphological and molecular methods. The bugs were screened for mycobacterial DNA and a selection of 20 mycobacteria-positive specimens from the families Gerridae and Veliidae were subjected to next-generation sequencing. Only one individual revealed putative M. ulcerans DNA, but all specimens contained sequences from the widespread alpha-proteobacterial symbiont, Wolbachia. Phylogenetic analysis placed the Wolbachia sequences into supergroups A, B and F. Circularized mitogenomes were obtained for seven gerrids and two veliids, the first from these families for the African continent. This study suggests that aquatic Hemiptera may have a minor role (if any) in the spread of BU in Southwest Cameroon. Our metagenomic analysis provides new insights into the incursion of Wolbachia into aquatic environments and generates valuable resources to aid molecular taxonomic studies of aquatic Hemiptera.

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“…While the culturing of M. ulcerans from an aquatic invertebrate (Portaels et al, 2008) suggested a potential reservoir or vector for BU (e.g., Merritt et al, 2010), Benbow et al (2008) discounted predatory aquatic insects as a potential vector because the number of insects and presence of M. ulcerans in these insects are similar at BU-endemic and non-endemic sites. However, more recent work indicates that perhaps aquatic biting insects are indeed the cause, as suggested by correlations between biting insect distribution and prevalence of BU (Carolan et al, 2014a) and, more directly, one case study of a six-year old girl (Marion et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Chemistry of natural waters and its relation to Buruli ulcer in Ghana

Hagarty

Azanu

Atosona

et al. 2015

Journal of Hydrology: Regional Studies

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a b s t r a c tStudy region: Buruli ulcer, an emerging disease caused by Mycobacterium ulcerans, largely affects poor rural populations in tropical countries. The environmental niche that supports this necrotizing bacterium is unclear. Here, water samples were collected from five communities within Ghana in the rainy season in 2011: four in the southern part of Ghana (three disease-endemic communities: Pokukrom, Betenase, and Ayanfuri, and one control: Kedadwen) and one non-endemic community (Nangruma) in the north. Study focus: Past studies of Buruli ulcer conclude that water quality is, in some way, closely related to the transmission of this disease. This work serves as a first step to explore links between Buruli ulcer incidence and water quality. More broadly, this research works toward identifying the environmental niche for M. ulcerans, providing characterization of water bodies hazardous to human health in at-risk communities. New hydrological insights: Trace metals, thought to aid in the preferential growth of M. ulcerans, are present in higher concentrations in mining pits and stagnant pools than in other tested water bodies. Arsenic in particular could serve as a double threat for BU incidence: it could support the growth of M. ulcerans while suppressing immune systems, making the population more susceptible to disease. Few other differences between endemic and non-endemic communities exist, implying other variables such as human behavior may also control the onset of Buruli ulcer.

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A case of guilt by association: Water bug bite incriminated in M. ulcerans infection

Cited by 18 publications

References 19 publications

Buruli Ulcer in South Western Nigeria: A Retrospective Cohort Study of Patients Treated in Benin

Buruli Ulcer in South Western Nigeria: A Retrospective Cohort Study of Patients Treated in Benin

Aquatic Hemiptera in Southwest Cameroon: Biodiversity of Potential Reservoirs of <em>Mycobacterium ulcerans</em> and Multiple <em>Wolbachia</em> Sequence Types Revealed by Metagenomics

Chemistry of natural waters and its relation to Buruli ulcer in Ghana

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