A Case of Granulocyte-Colony Stimulating Factor Producing Multiple Gastric Carcinoma

Eto, Takaaki; Kuroda, Satoshi; Takahashi, Makoto; Sakimoto, Hideto; Koide, Kei; Kadoya, Takayuki; Akimoto, Naotaka; Dohi, Kiyohiko; Nishida, Toshihiro

doi:10.5833/jjgs.39.457

Cited by 6 publications

(4 citation statements)

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“…As in our case, recurrent G-CSF-producing tumor is mainly local recurrence and liver metastasis [4][5][6][7][8]. CT and US are useful to detect anatomical change or to compare with a previous study, therefore they are not good for local recurrence after surgery or diffuse infiltration of the tumor, especially in the early phase.…”

Section: Discussionmentioning

confidence: 81%

“…Sporadically reports are available, and most of the reports are written by Japanese, however, it may not mean difference of racial or geographic prevalence but of recognition among society. To our knowledge, 37 cases of G-CSFproducing gastric cancer have been reported [4][5][6][7][8]. Among these, men:women was 31:6 and median age was 68 (45-92).…”

Section: Discussionmentioning

confidence: 97%

“…Adenosquamous cell carcinoma was shown in 5 cases and the prevalence of adenosquamous cell carcinoma of the stomach is relatively high [6]. Eto et al [4] described double G-CSFproducing gastric cancer. Prognosis of G-CSF-producing gastric cancer is very poor and the median survival was 14 months (95% CI 8-16 months) among 30 cases with 15:191-195 193 described prognosis.…”

Section: Discussionmentioning

confidence: 98%

“…Although 37 case reports of G-CSF-producing gastric cancer had been described by 2008 [4][5][6][7][8], the rarity of the disease makes its features unknown.…”

Section: Introductionmentioning

confidence: 96%

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Aggressive recurrence of gastric cancer as a granulocyte-colony-stimulating factor-producing tumor

et al. 2010

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A 62-year-old Japanese man presented with a 1-month history of inter-digestive epigastralgia. His family history included a sister with gastric cancer. Gastroendoscopy and gastrography demonstrated a type-2 tumor in the upper region of the stomach. CT scan and fluorodeoxyglucose-positron emission tomography (FDG-PET) scan demonstrated gastric cancer and its metastatic lymph nodes. The patient underwent total gastrectomy with splenectomy and extended lymph node dissection. Although postoperative adjuvant chemotherapy by S-1 was started, the deteriorating condition of the patient prevented drug administration and even eating meals. On the 19th postoperative day (POD), FDG-PET scan of the body demonstrated new uptake in the liver and lymph node around the aorta. Without any sign of infection, leukocytosis developed around the 30th POD. On the 49th POD, remarkable uptake in the whole upper abdomen was detected on FDG-PET scan. Finally, leukocyte count increased to 125,200 and granulocyte colony stimulating factor (G-CSF) was elevated to 28 pg/ml on the 54th POD. The patient died of multiple liver metastases and carcinomatous peritonitis only 56 days after surgery. G-CSF-producing tumor is a rare but aggressive disease, particularly as recurrent tumor. If leukocytosis is detected in relation to a non-lympho hematopoietic malignant tumor, G-CSF-producing tumor should be considered and FDG-PET scan is recommended for early detection. Chemotherapy for G-CSF-producing tumor must be conducted as soon as possible.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

“…Although 37 case reports of G-CSF-producing gastric cancer had been described by 2008 [4][5][6][7][8], the rarity of the disease makes its features unknown.…”

Section: Introductionmentioning

confidence: 96%

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Aggressive recurrence of gastric cancer as a granulocyte-colony-stimulating factor-producing tumor

et al. 2010

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A Case of Successful Treatment of ROS1-positive Granulocyte Colony-stimulating Factor-producing Lung Adenocarcinoma with an ROS1 Tyrosine Kinase Inhibitor

Yasui,

Matsumoto,

Hyakudo

et al. 2024

JJLC

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━━ Background. Granulocyte colony-stimulating factor (G-CSF)-producing tumors are known to have a poor prognosis, and the efficacy of ROS1 tyrosine kinase inhibitors (ROS1-TKIs) in treating ROS1 fusion genepositive G-CSF-producing non-small-cell lung cancer has not been reported. Case. A 56-year-old male patient presented with a rapidly progressing mediastinal tumor and an abnormally high white blood cell count. The diagnosis was lung adenocarcinoma (cTXN3M1c, stage IVB). Serum G-CSF levels were elevated. Due to the rapid progression, we started carboplatin, paclitaxel, bevacizumab, and atezolizumab without awaiting the results of gene mutation testing. However, he experienced progressive disease (PD) after two courses. Subsequently, he was administered cisplatin, pemetrexed, and bevacizumab, but PD occurred again after two courses. After confirming ROS1 fusion gene positivity and starting entrectinib, the dyspnea improved the next day, and 1.5 months later, computed tomography showed shrinkage of the tumor. PD occurred three months after starting entrectinib, and we switched to crizotinib. The tumor shrank rapidly again. Conclusion. ROS1-TKIs may be effective, even for ROS1 fusion gene-positive G-CSF-producing tumors with a poor prognosis.

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Granulocyte-colony Stimulating Factor-Producing Gastric Cancer that Showed Rapid Recurrence and Progression—A Case Report—

Asanuma

Yoshida

Ishigooka

et al. 2020

Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)

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Granulocyte-colony stimulating factor (G-CSF)-producing gastric cancer is a rare disease with a very poor prognosis. A case of this disease that recurred rapidly and progressed is presented. A 76-year-oldmanwhohadepigastricpainwasadmittedtoourhospital.Uppergastrointestinalendoscopy andbiopsyshowedatumorof5.0cmormore,apoorlydifferentiatedadenocarcinoma(por).Abdominal enhancedcomputedtomography(CT)showedagiantmassof7.0cmonthewallofthelessercurvature andmultipleenlargedlymphnodesaroundthestomach.Thepreoperativelaboratorydatashowedleuko-cytosisandahighserumG-CSFlevel(1,010pg/ml).Therewerenoapparentsourcesofinfectionorblood diseases.AG-CSF-producinggastriccancerwassuspected,andtotalgastrectomywasperformed.Pathologicalfindingswerepor,pT4a(SE),pN1,M0,andStageIIIA.ThetumorcellswerepositiveonG-CSF immunological staining. Postoperatively, the leukocyte count improved once, but it then gradually increased.Onpostoperativeday(POD)19,abdominalenhancedCTshowedtwolow-densitymasses,one largerthan5.0cminthebodyofthepancreasandone3.0cminthetailofthepancreas.Themassessuspectedtobeabscessesenlargedgradually,andrecurrenceoftheG-CSF-producinggastrictumorwasdiagnosed.S-1+trastuzumabtreatmentwasstartedonPOD25.ThepatientwasdischargedonPOD34, butdevelopedcardiopulmonaryarrestonPOD36.

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A Case of Granulocyte-Colony Stimulating Factor Producing Multiple Gastric Carcinoma

Cited by 6 publications

References 0 publications

Aggressive recurrence of gastric cancer as a granulocyte-colony-stimulating factor-producing tumor

Aggressive recurrence of gastric cancer as a granulocyte-colony-stimulating factor-producing tumor

A Case of Successful Treatment of ROS1-positive Granulocyte Colony-stimulating Factor-producing Lung Adenocarcinoma with an ROS1 Tyrosine Kinase Inhibitor

Granulocyte-colony Stimulating Factor-Producing Gastric Cancer that Showed Rapid Recurrence and Progression—A Case Report—

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