A Case of Granular Cell Tumor of the Clitoris in a Postmenopausal Woman

Min, Jiwon; Kim, Yun Sook

doi:10.6118/jmm.2017.23.2.135

“…After complete excision, histopathological features suggestive of pyogenic granuloma. 7 Claudio Guerrieri et al in 2019 published a case report in the international journal of gynecological pathology in regards to vulvar Silicone Granuloma in a 51 year old multiparous lady following a labia majora augmentation surgery using silicone-based liquid injection. It's a type a foreign body granuloma when silicone is used with the intention of enhancing the labia majora as a part of esthetic procedure.…”

Section: Discussion Partmentioning

confidence: 99%

A Clitoral mass in postmenopausal women: a diagnostic dilemma

Kanchan

¹

,

Garg

²

,

Kyalakond

³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Clitoral mass is not commonly encountered in Gynecology practice and the literature is scanty. Clitoral mass can be due to Cancer, Granuloma, epidermoid cyst, peri-clitoral abscess, fibroid and Neuromas 1 and clinical presentation is overlapping making it difficult to diagnose. Clitoral cancer is a form of vulvar cancer, is an unpleasant dreadful malignancy and is very rare. Rare case reports of pyogenic granuloma of the labia and clitoris in postmenopausal women with similar presentation and diagnosed by histopathology requiring excision. Similarly neuromas of clitoris are also a known entity seen mainly after FGM.Aim : Awareness regarding the rare causes of clitoral mass including malignancy and granuloma with their overlapping symptoms.Materials & Methods : Prospective observational case report. Conclusion:A Multidisciplinary approach is important to diagnose and differentiate the clitoris granuloma from that of malignancy. The clinical examination and imaging can be misleading at times and diagnosis is only by histopathology Clinical Significance: Multidisciplinary team involvement and through counseling is needed. Significance of clitoris is well established as the most vital part in sexual function, there is an urgent need to focus our attention on more and more case reports and reviews on its literature of disease related to clitoris.

show abstract

“…[1][2][3][4] The majority of GCTs are found in the skin, subcutaneous tissue and submucosa with a handful of case reports discussing primary GCTs in the clitoris. 5,6 Most cases are benign with only 2% being malignant. 5,7 There is no known genetic predisposition to GCT.…”

mentioning

confidence: 99%

Giant myoma associated with uterine prolapse during the second trimester of twin pregnancy: case report

Ribeiro¹,

Nakamura²,

França³

et al. 2021

OGIJ

0

View full text Add to dashboard Cite

Background: Granulosa Cell tumors (GCT) are a sex-cord stroma tumor comprising of 1-2% of ovarian malignancies. Derived from Schwann cells, GCTs are comprised of granulosa cells, a cell of the ovarian stroma. Patients with these tumors present with signs of increased estrogen such as vaginal bleeding, irregular menstruation and rarely hirsutism and virilization.8,10-12 The majority of GCTs are found in the skin, subcutaneous tissue and submucosa with a handful of case reports discussing primary GCTs in the clitoris.3,7 Surgery is required for definitive tissue diagnosis and staging. In this case report, we present a case with tissue diagnosis for granulosa cell tumor found on the clitoral hood. Case: A 56-year-old, female, G6P3033 initially presented for evaluation of persistent clitoral cyst for >2 years Initial evaluation was significant for 1 cm clitoral cyst that was firm, smooth and fluctuant with no irregular borders; with worsening vulvodynia. The patient underwent clitoral hood mass excision. The mass was excised entirely and the post-operative recovery was uncomplicated. Pathology findings were significant for completely excised granulosa cell tumor; margins were negative for tumor. Immunohistochemical stain was positive for CD56, CD68, Vimentin, and S-100, and negative for AE1/13, CD31, CD34, SMA, and Desmin. Conclusion: When evaluating chronic, persistent, or recurrent masses, it is important to take into consideration both benign and malignant causes. Definitive diagnosis is established pathologically. Patients with confirmed GCT should be thorough evaluated pre-operatively with blood work and appropriate imaging. Upon diagnosis, patient with GCT should be regularly followed for recurrence and surveillance.

show abstract

“…Microscopically, GCT is made up of granulosa cells -small, pale, round cells with "coffee bean" nuclei and eosinophilic cytoplasmic granules. 2,3,6,8 Surgery is required for definitive tissue diagnosis and staging. In this case report, we retrospectively studied the clinical presentation and histopathology in a patient with a clitoral hood granulosa tumor.…”

mentioning

confidence: 99%

Clitoral HOOD granulosa cell tumor; case report and review of literature

Patel¹,

Hamilton²,

Fievre³

2021

OGIJ

0

View full text Add to dashboard Cite

Background: Granulosa Cell tumors (GCT) are a sex-cord stroma tumor comprising of 1-2% of ovarian malignancies. Derived from Schwann cells, GCTs are comprised of granulosa cells, a cell of the ovarian stroma. Patients with these tumors present with signs of increased estrogen such as vaginal bleeding, irregular menstruation and rarely hirsutism and virilization.8,10-12 The majority of GCTs are found in the skin, subcutaneous tissue and submucosa with a handful of case reports discussing primary GCTs in the clitoris.3,7 Surgery is required for definitive tissue diagnosis and staging. In this case report, we present a case with tissue diagnosis for granulosa cell tumor found on the clitoral hood. Case: A 56-year-old, female, G6P3033 initially presented for evaluation of persistent clitoral cyst for >2 years Initial evaluation was significant for 1 cm clitoral cyst that was firm, smooth and fluctuant with no irregular borders; with worsening vulvodynia. The patient underwent clitoral hood mass excision. The mass was excised entirely and the post-operative recovery was uncomplicated. Pathology findings were significant for completely excised granulosa cell tumor; margins were negative for tumor. Immunohistochemical stain was positive for CD56, CD68, Vimentin, and S-100, and negative for AE1/13, CD31, CD34, SMA, and Desmin. Conclusion: When evaluating chronic, persistent, or recurrent masses, it is important to take into consideration both benign and malignant causes. Definitive diagnosis is established pathologically. Patients with confirmed GCT should be thorough evaluated pre-operatively with blood work and appropriate imaging. Upon diagnosis, patient with GCT should be regularly followed for recurrence and surveillance.

show abstract

A Case of Granular Cell Tumor of the Clitoris in a Postmenopausal Woman

Cited by 3 publications

References 15 publications

A Clitoral mass in postmenopausal women: a diagnostic dilemma

A Clitoral mass in postmenopausal women: a diagnostic dilemma

Giant myoma associated with uterine prolapse during the second trimester of twin pregnancy: case report

Clitoral HOOD granulosa cell tumor; case report and review of literature

Contact Info

Product

Resources

About