A case of giant dental calculus in a patient with centronuclear myopathy

Iwama, Ryosuke; Nagai, Hirokazu; Suzuki, Naoki; Izumi, Rumiko; Kumamoto, Hiroyuki; Takahashi, Tetsu

doi:10.1111/scd.12772

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…2 ). Abnormally high amounts of calculus deposition could occasionally be seen in modern patients, but the underlying cause is unidentifiable in most cases 55 , 56 . At least, this individual would not have a routine tooth cleaning habit during the period of calculus deposition.…”

Section: Discussionmentioning

confidence: 99%

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

Uchida-Fukuhara,

Shimamura,

Sawafuji

et al. 2024

Sci Rep

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Detailed investigation of extremely severe pathological conditions in ancient human skeletons is important as it could shed light on the breadth of potential interactions between humans and disease etiologies in the past. Here, we applied palaeoproteomics to investigate an ancient human skeletal individual with severe oral pathology, focusing our research on bacterial pathogenic factors and host defense response. This female skeleton, from the Okhotsk period (i.e., fifth to thirteenth century) of Northern Japan, poses relevant amounts of abnormal dental calculus deposition and exhibits oral dysfunction due to severe periodontal disease. A shotgun mass-spectrometry analysis identified 81 human proteins and 15 bacterial proteins from the calculus of the subject. We identified two pathogenic or bioinvasive proteins originating from two of the three “red complex” bacteria, the core species associated with severe periodontal disease in modern humans, as well as two additional bioinvasive proteins of periodontal-associated bacteria. Moreover, we discovered defense response system-associated human proteins, although their proportion was mostly similar to those reported in ancient and modern human individuals with lower calculus deposition. These results suggest that the bacterial etiology was similar and the host defense response was not necessarily more intense in ancient individuals with significant amounts of abnormal dental calculus deposition.

show abstract

Section: Discussionmentioning

confidence: 99%

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

Uchida-Fukuhara,

Shimamura,

Sawafuji

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Stable isotope analysis showed that HM2-HA-3 had a similar diet to other individuals from the Hamanaka 2 site and other individuals from Hamanaka 2 site displayed little or no calculus deposition (Figure 2). Abnormally high amounts of calculus deposition could occasionally be seen in modern patients, but the underlying cause is unidentifiable in most cases 68,69 . At least, this individual would not have a routine tooth cleaning habit during the period of calculus deposition.…”

Section: Discussionmentioning

confidence: 99%

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

Uchida-Fukuhara

Shimamura

Sawafuji

et al. 2023

Preprint

View full text Add to dashboard Cite

Detailed investigation of extremely severe pathological conditions in ancient human skeletons is important as it could shed light on the breadth of potential interactions between humans and disease etiologies in the past. Here, we applied palaeoproteomics to investigate an ancient human skeletal individual with severe oral pathology, focusing our research on bacterial pathogenic factors and host defense response. This female skeleton, from the Okhotsk period (i.e., 5th to 13th century) of Northern Japan, poses relevant amounts of abnormal dental calculus deposition and exhibits oral dysfunction due to severe periodontal disease. A shotgun mass-spectrometry analysis identified 81 human proteins and 15 bacterial proteins from the calculus of the subject. We identified two pathogenic or bioinvasive proteins originating from two of the three red complex bacteria, the core species associated with severe periodontal disease in modern humans, as well as two additional bioinvasive proteins of periodontal-associated bacteria. Moreover, we discovered defense response system-associated human proteins, although their proportion was mostly similar to those reported in ancient and modern human individuals with lower calculus deposition. These results suggest that the bacterial etiology was similar and the host defense response was not necessarily more intense in ancient individuals with significant amounts of abnormal dental calculus deposition.

show abstract

A case of giant dental calculus in a patient with centronuclear myopathy

Cited by 2 publications

References 22 publications

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus

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