A case of giant cell arteritis presenting with nodular posterior scleritis mimicking a choroidal mass

Awh, Caroline; Reichstein, David; Thomas, Akshay S.

doi:10.1016/j.ajoc.2019.100583

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…Atypical presentations of GCA can also present with undifferentiated constitutional symptoms (pyrexia of unknown origin (PUO), fatigue, weight loss) and organ-related ischaemia or inflammatory disorders including mucocutaneous (lingual and scalp necrosis, panniculitis),7–12 neurological (mononeuritis multiplex, cerebral vasculitis, cranial nerve palsies, acute stroke),13–17 ocular (uveitis, choroidal infarction),18–21 musculoskeletal (peripheral joint arthritis, focal myositis)22–24 and inflammatory pseudotumour (skin, uterine, breast),25–28 along with orchitis, myocardial infarction and mesenteric ischaemia 29–32…”

Section: Discussionmentioning

confidence: 99%

Atypical giant cell arteritis presentations diagnosed with FDG-18 whole body PET imaging

Vijayaraghavan¹,

Martin

Jayawickrama³

et al. 2023

BMJ Case Rep

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Two male patients aged above 70 years were investigated for chronic non-specific symptoms and evidence of significant systemic inflammation, but without classic ‘cranial symptoms’ of giant cell arteritis (GCA). Each patient had multiple non-diagnostic investigations, but finally extensive large-vessel vasculitis was revealed by whole body positron emission tomography/CT imaging. Both cases were confirmed to have GCA on temporal artery biopsy and responded well to initial high-dose prednisolone therapy. The patients successfully completed 12 months of steroid-sparing therapy with tocilizumab and achieved remission of their condition.

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Section: Discussionmentioning

confidence: 99%

Atypical giant cell arteritis presentations diagnosed with FDG-18 whole body PET imaging

Vijayaraghavan¹,

Martin

Jayawickrama³

et al. 2023

BMJ Case Rep

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“…Regarding GCA, acute sensorineural hearing loss rarely occurs in patients with GCA (27). Common ocular involvements in GCA are amaurosis and diplopia (28), and there have been few reports of patients with GCA who developed scleritis (29)(30)(31). Since CS is defined as variable vessel vasculitis (VVV) by the 2012 revised International Chapel Hill Consensus Conference (CHCC) Nomenclature of Vasculitides (32), we considered the present case to be one of CS mimicking GCA.…”

Section: Discussionmentioning

confidence: 99%

Atypical Cogan's Syndrome Mimicking Giant Cell Arteritis Successfully Treated with Early Administration of Tocilizumab

et al. 2022

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A 49-year-old Japanese man with a 2-month history of a fever, headache, and bilateral conjunctival hyperemia was admitted. His condition fulfilled the giant cell arteritis classification criteria (new headache, temporal artery tenderness, elevated ESR) and atypical Cogan's syndrome (CS) with scleritis and sensorineural hearing loss (SNHL). The interleukin (IL)-6 serum level was extremely high. Two weeks after his insufficient response of SNHL and scleritis to oral prednisolone, we administered tocilizumab (TCZ); rapid improvements in scleritis and SNHL occurred. Early IL-6 target therapy can help prevent irreversible CS-induced sensory organ damage.

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“…Other differentials that should be considered for an amelanotic mass lesion include choroidal melanoma, choroidal metastasis, and choroidal heman- gioma (3). A few reports have described a similar kind of lesion associated with systemic lupus erythematosus (1) and giant cell arteritis (21). A scleral biopsy in a similar scenario revealed a thickened sclera infiltrated by chronic inflammatory cells (lymphocytes and eosinophils).…”

Section: Discussionmentioning

confidence: 99%

Posterior Scleritis Simulating Choroidal Melanoma: Case Report

Khadka¹

2021

Beyoglu Eye J

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A 52-year-old male presented with the complaints of diminution of vision in the left eye (LE) accompanied by mild Nodular posterior scleritis (NPS) is rare; however, it is critical to differentiate it from similar intraocular pathologies to prevent inappropriate and potentially irreversible treatment. Multimodal imaging is beneficial in the diagnosis of NPS. This report describes the diagnosis and management of a case of NPS with corticosteroid therapy that led to complete resolution.

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A case of giant cell arteritis presenting with nodular posterior scleritis mimicking a choroidal mass

Cited by 8 publications

References 10 publications

Atypical giant cell arteritis presentations diagnosed with FDG-18 whole body PET imaging

Atypical giant cell arteritis presentations diagnosed with FDG-18 whole body PET imaging

Atypical Cogan's Syndrome Mimicking Giant Cell Arteritis Successfully Treated with Early Administration of Tocilizumab

Posterior Scleritis Simulating Choroidal Melanoma: Case Report

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