A Case of Generalized Juvenile Gastrointestinal Polyposis Associated with Gastric Carcinoma

Yoshida, Teruo; Haraguchi, Yukiaki; Tanaka, Akira; Higa, A.; Daimon, Yumi; Mizuta, Yohei; Tamaki, Masanori; Uehara, Yuko; Tanaka, Kosuke

doi:10.1055/s-2007-1018122

Cited by 27 publications

(6 citation statements)

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“…This suggests role in the “multiple” adenoma phenotype [128]. Additionally, there are many reports of patients with juvenile polyposis developing gastrointestinal malignancy, including cancer of the colon [129, 130], stomach [129–131], and pancreas [129, 132]. Whether these mutations may directly contribute to the preceding cancers or whether they create a favorable environment that makes a person more susceptible to stomach and colon cancer is not known at this time.…”

Section: Evidence Of Bmp Involvement In Tumorigenesismentioning

confidence: 99%

The Yin and Yang of bone morphogenetic proteins in cancer

Singh

Morris

2010

Cytokine & Growth Factor Reviews

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Bone morphogenetic proteins (BMPs) were first studied as growth factors or morphogens of the transforming growth factor-beta super family. These growth molecules, originally associated with bone and cartilage development, are now known to play important roles in morphogenesis and homeostasis in many other tissues. More recently, significant contributions of BMPs, their receptors, and interacting molecules have been linked to carcinogenesis and tumor progression. On the other hand, BMPs can sometimes play a role as a tumor suppressor. Our report highlights these new roles in the pathogenesis of cancer that may suggest novel targets for therapeutic intervention. KeywordsBone Morphogenetic Proteins; Bone morphogenetic receptors; TGF-β; Cancer; Metastasis 1.0. Introduction BMP introduction, signaling cascades, and interacting moleculesBone Morphogenetic Proteins (BMPs) are a family of evolutionarily conserved growth factors and morphogens most of which belong to the transforming growth factor-β (TGF-β) super-family. BMPs were discovered by Marshall Urist in 1965, who found that decalcified bone matrix fragments have bone induction activity when transplanted into rats and rabbits [1]. Wozney et al., (1988) isolated and identified molecules from bone extracts capable of inducing bone and cartilage formation and named them BMPs [2]. Further studies reveal that BMPs not only regulate bone and cartilage, but exert a wide range of morphogenetic activity that is both tissue and context dependent [3,4,5].BMPs exist as dimeric pro-protein complexes in the cytoplasm that are cleaved by proteases before their intended action. After the BMP molecules are secreted, they are further processed by another layer of regulators, Noggin and Chordin, and then bind to their specific receptors on the plasma membrane of their target cells [6,7]. BMPs exert their activities by way of serine-threonine kinase receptors of which there are three type-I and three type-II [8]. Different BMPs show preference in the combination of receptors, but in general utilize one receptor of each type [9,10]. As most BMPs are TGF-β family members, they tend to use the same signaling pathways, principally MAPK and SMAD, although Notch and WNT are also used [11][12][13]. Binding of the BMPs to their specific receptors triggers cross phosphorylation of the type-I receptor by the type-II receptor [14]. The type-I receptor then © 2010 Elsevier Ltd. All rights reserved * Corresponding author at: Stem Cells and Cancer 801 16 th Ave NE Hormel Institute/Univ. Minnesota Austin, MN 55912, USA Phone: 507-437-9630 FAX: 507-437-9606 rmorris@hi.umn.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affec...

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Section: Evidence Of Bmp Involvement In Tumorigenesismentioning

confidence: 99%

The Yin and Yang of bone morphogenetic proteins in cancer

Singh

Morris

2010

Cytokine & Growth Factor Reviews

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“…Both siblings underwent a total gastrectomy, and although their stomachs were found to be diffusely involved with typical juvenile polyps, there was no evidence of dysplasia or cancer150. Yoshida et al reported a 31 year old JP patient that was diagnosed with a well-differentiated gastric adenocarcinoma, and concluded that JP patients are also at risk for gastric cancer156. Sassatelli et al reported a 16 year old JP patient with diffuse polyposis of the stomach, who later developed an infiltrating adenocarcinoma from one of the JP polyps in the stomach at the age of 21129.…”

Section: Juvenile Polyposis Syndrome (Jps)mentioning

confidence: 99%

“…Patients with generalized JP should undergo close surveillance of the upper GI tract because of the high risk of malignancy43,55,60,68, Jarvinen, 1984 #570,131,156. Howe et al recommended screening the upper GI tract by EGD starting at the age 15 for asymptomatic individuals at risk, or as soon as signs or symptoms develop.…”

Section: Juvenile Polyposis Syndrome (Jps)mentioning

confidence: 99%

Hamartomatous Polyposis Syndromes

Calva

Howe

2008

Surgical Clinics of North America

127

116

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SynopsisSince the histological description of the hamartomatous polyp in 1957 by Horrilleno et al., several different syndromes have been described with the propensity to develop these polyps in the upper and lower GI tracts. These include Juvenile Polyposis, Peutz-Jeghers syndrome, hereditary mixed polyposis syndrome, and the PTEN hamartoma tumor syndromes (Cowden and Bannayan-RileyRuvalcaba syndromes), which are autosomal-dominantly inherited, and Cronkhite-Canada syndrome, which is acquired. The clinical aspects, the molecular pathogenesis, the organ systems affected, the risks of cancer, and the management of these hamartomatous polyposis syndromes will be reviewed in this paper. Although the incidence of these syndromes is low, it is important for clinicians to recognize these disorders in order to prevent morbidity and mortality in these patients, and to perform presymptomatic testing in patients at risk.

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“…[1314] The diagnostic criteria for juvenile polyposis syndrome are somewhat controversial, but we have followed the guidelines outlined by Giardiello et al . [15] Initially, the indications of surgical intervention for JPS were as follows: when polyps are numerous and difficult to control endoscopically, if symptoms such as bleeding and diarrhea are troublesome, or when there is any suspicion of cancer;[1617] however, recently, prophylactic surgical intervention is considered as the treatment of choice.…”

Section: Discussionmentioning

confidence: 99%

Juvenile polyposis syndrome

Upadhyaya

Gangopadhyaya

Sharma

et al. 2008

J Indian Assoc Pediatr Surg

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Aim:Report of a series of 12 cases of juvenile polyposis coli.Methods:The study period was from 1995 to 2005. All the patients were treated by total colectomy with rectal mucosectomy and endorectal ileoanal pullthrough with or without ileal pouch formation. Covering ileostomy was avoided in all the cases. Time taken for the surgery, postoperative complications and continence were documented.Results:The mean operating time was 4.2 h (range: 4–5 h). The mean duration of hospital stay was 16.3 days (range: 15–18 days). The most common postoperative complication was pouchitis and perianal excoriation. Initially, all the patients were passing stools at an interval of 2 h, and after 3 weeks, the frequency has reduced to 6–8 stools per day. In the follow-up after 3 months, the frequency was 3–5 per day with minimal soiling.Conclusions:Single-stage total colectomy with rectal mucosectomy and endorectal ileoanal pull-through without covering ileostomy and pouch formation is a safe and definitive treatment for juvenile polyposis coli if the patient selection is appropriate.

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A Case of Generalized Juvenile Gastrointestinal Polyposis Associated with Gastric Carcinoma

Cited by 27 publications

References 0 publications

The Yin and Yang of bone morphogenetic proteins in cancer

The Yin and Yang of bone morphogenetic proteins in cancer

Hamartomatous Polyposis Syndromes

Juvenile polyposis syndrome

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