A case of fulminant varicella infection with purpura fulminans, hepatitis, and rhabdomyolysis

Karadağ, Ayşe Serap; Bilgili, SG; Çalka, Ömer; Çeçen, İlhan; Akbayram, Sinan

doi:10.4103/0019-5154.103079

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…Sometimes bleeding may occur from various mucous membranes. 5,6 Disseminated varicella occurs in the neonate when the mother gets infected 1-4 days before delivery while the risk for congenital varicella syndrome is most in the first 20 weeks of pregnancy. 2,4 This syndrome is marked by limb hyperplasia, chorioretinitis, cortical atrophy, and cutaneous scars.…”

Section: Discussionmentioning

confidence: 99%

Varicella bullosa in an adult

Sinha¹,

Bhattacharjee²,

Chatterjee

2017

Medical Journal Armed Forces India

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Section: Discussionmentioning

confidence: 99%

Varicella bullosa in an adult

Sinha¹,

Bhattacharjee²,

Chatterjee

2017

Medical Journal Armed Forces India

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“…The multiple organ failure and sepsis had occurred in patient that had thrombocytopenia. Purpura fulminans is the cutaneous manifestation of disseminated intravascular coagulation and results in microvascular thrombosis together with hemorrhagic skin and soft tissue necrosis (8). In our case, soft tissue necrosis and hemorrhages on extremities defined as purpura fulminans were dressed daily.…”

Section: Discussionmentioning

confidence: 87%

Acute Osteomyelitis After Varicella Infection in an Infant: A Case Report

Sütçü¹,

Yılmaz²,

Salman³

et al. 2017

J Pediatr Inf

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Varicella infections in infants are commonly self-limited disease but sometimes can cause severe complications and also result in death. The varicella vaccine is highly effective in preventing severe varicella and has significantly decreased varicella incidence, hospitalizations, and deaths. The most common complications of Varicella infection that require hospitalization are skin/soft tissue infections, bone/joint infections, sepsis, pneumonia, thrombocytopenia and dehydration. Here we report, a ten-month-old female infant hospitalized for varicella sepsis and purpura fulminans. In the first month of her treatment, osteomyelitis of left elbow has occurred and operated and treated successfully. Osteomyelitis should always be considered in any child who develops pain, swelling and limitation of movement in a limb during or after varicella infection.

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“…Some patients have developed meningoencephalitis or varicella pneumonia. [11][12][13] The incidence of AKI in rhabdomyolysis is not known, but it is estimated that between 33% and 40% of patients with rhabdomyolysis develop AKI. 14 Attempts to identify patients at highest risk of AKI have revealed that no single laboratory value, including serum CPK concentrations, can predict which patients are at risk of developing AKI.…”

Section: Discussionmentioning

confidence: 99%

“…Other complications may be linked specifically to the location of the VZV and not as a direct consequence of the rhabdomyolysis. Some patients have developed meningoencephalitis or varicella pneumonia 11‐13 …”

Section: Discussionmentioning

confidence: 99%

Myalgia‐induced discovery of rhabdomyolysis complicating generalized varicella in an immunocompetent patient: Case report and review of the literature

Bayala,

Ayouba Tinni,

Ouedraogo

et al. 2024

Clinical Case Reports

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Key clinical messageIn a rare occurrence, primary varicella infection led to rhabdomyolysis in a 24‐year‐old with no medical history. Presenting with rash, fever, and weakness, he developed diffuse myalgia at 72 h. Elevated muscle enzymes confirmed rhabdomyolysis secondary to varicella zoster virus (VZV) infection. Treatment with acyclovir and hydration resulted in significant improvement within a month.AbstractPrimary varicella infection is rarely complicated by rhabdomyolysis. In this study, we describe a case of rhabdomyolysis complicating a VZV infection in a black subject. The patient was a 24‐year‐old black African with no particular medical history and was immunocompetent. He presented with an acute onset of generalized rash, fever, and generalized weakness. Physical examination revealed vesicular lesions typical of chickenpox. Antipyretic treatment combined with acyclovir was instituted in hospital. At the 72nd hour, diffuse myalgia developed. Muscle enzyme tests revealed CPK elevated to 40 times the upper limit of normal, LDH elevated to 2 times the upper limit of normal, ASAT and ALAT elevated to 7 times the upper limit of normal, and 2.5 times the upper limit of normal, respectively. We accepted the diagnosis of rhabdomyolysis secondary to VZV infection. The patient was given saline hydration and showed clinical and biological improvement 1 month later. A patient presenting with muscular symptoms during a VZV infection should be considered for rhabdomyolysis.

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A case of fulminant varicella infection with purpura fulminans, hepatitis, and rhabdomyolysis

Cited by 10 publications

References 12 publications

Varicella bullosa in an adult

Varicella bullosa in an adult

Acute Osteomyelitis After Varicella Infection in an Infant: A Case Report

Myalgia‐induced discovery of rhabdomyolysis complicating generalized varicella in an immunocompetent patient: Case report and review of the literature

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