A case of fibromatosis gingivae

Araiche, Manawel; Brode, Herbert

doi:10.1016/0030-4220(59)90218-x

Cited by 22 publications

(12 citation statements)

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“…The clinical features observed in this patient overlap only in part with reported observations of GO associated with GH, MR or epilepsy or with ZLS and related phenotypes (Araiche and Brode, 1959;Nevin et al, 1971;Vontobel, 1973;Bakaeen and Scully, 1991;Haytac and Ozcelik, 2007) (Table 1). Tonic-clonic seizures have been reported so far in just a single patient with ZLS, who did not manifest GH (Chodirker et al, 1986).…”

Section: Discussionsupporting

confidence: 50%

Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview

Douzgou¹,

Mingarelli

Dallapiccola³

2009

Clinical Dysmorphology

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We report on a patient with congenital generalized hypertrichosis, mental retardation, tonic-clonic seizures with onset during the first year of life and gingival overgrowth, unrelated to antiepileptic treatment. This phenotype represents a unique combination of features, bridging the variable association of gingival overgrowth, generalized hypertrichosis, mental retardation or epilepsy. This may occur in combination with nail and/or digital anomalies, as in Zimmermann-Laband syndrome, and the broader phenotypes of the Anavi, Göhlich-Ratmann and Ramon syndromes. On the basis of the clinical overlap between our patient and these disorders inherited either as autosomal dominant or recessive traits and unknown molecular defects, a recurrence risk of one in four was considered appropriate.

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Section: Discussionsupporting

confidence: 50%

Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview

Douzgou¹,

Mingarelli

Dallapiccola³

2009

Clinical Dysmorphology

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“…(26) reported epithelial hyperplasia from acanthosis in gingival specimens from four patients affected with HGF, but only in those areas associated with chronic inflammation. Fletcher (28) and others (3, 24, 25) also described epithelial hyperplasia in HGF specimens with intense inflammatory cell infiltration. In the present study, the epithelial area of HGF and NG group was quite similar; however, our samples were free of inflammatory infiltration.…”

Section: Discussionmentioning

confidence: 92%

Histomorphometric characteristics and expression of epidermal growth factor and its receptor by epithelial cells of normal gingiva and hereditary gingival fibromatosis

Araújo¹,

Graner²,

Almeida³

et al. 2003

J of Periodontal Research

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“…Short areas of epithelial atrophy are eventually found between the papillae. Farrer‐Brown et al 66 and others 5,32,65,75 reported epithelial hyperplasia from acanthosis in gingival specimens from HGF patients, but samples were associated with chronic inflammation. Raeste et al 29 found epithelial hyperplasia and prominent papillae in areas with intense chronic inflammation, whereas areas without inflammation showed only long and deep epithelial papillae.…”

Section: Histologic Features Of Hgf Gingival Enlargementmentioning

confidence: 98%

“…4 and 5). 5,29,32,63‐66 Two populations of fibroblasts were identified in the lesional tissue 67,68 . One contains little cytoplasm around the nucleus, which is associated with dense collagen bundles, and the other contains ample smooth and rough endoplasmatic reticulum, a well‐developed Golgi apparatus, and numerous mitochondria in the cytoplasm.…”

Section: Histologic Features Of Hgf Gingival Enlargementmentioning

confidence: 99%

Hereditary Gingival Fibromatosis: A Systematic Review

Coletta

Graner

2006

Journal of Periodontology

151

185

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Generalized gingival enlargement can be caused by a variety of etiological factors. It can be inherited (hereditary gingival fibromatosis [HGF]); associated with other diseases characterizing a syndrome; or induced as a side effect of systemic drugs, such as phenytoin, cyclosporin, or nifedipine. HGF, previously known as elephantiasis gingivae, hereditary gingival hyperplasia, and hypertrophic gingiva, is a genetic disorder characterized by a progressive enlargement of the gingiva. This review will focus on diagnosis, treatment, and control of HGF. The pattern of inheritance, the histopathologic characteristics, and the known biologic and genetic features associated with HGF are also emphasized.

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A case of fibromatosis gingivae

Cited by 22 publications

References 1 publication

Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview

Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview

Histomorphometric characteristics and expression of epidermal growth factor and its receptor by epithelial cells of normal gingiva and hereditary gingival fibromatosis

Hereditary Gingival Fibromatosis: A Systematic Review

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