A Case of Esophageal Sarcomatoid Carcinoma with Molecular Evidence of a Monoclonal Origin

Kashiwabara, Kenji; Sano, Takaaki; Oyama, Tetsunari; Najahima, Takashi; Makita, Fujio; Hashimoto, Naoki; Iwanami, Koutaro; Kawashima, Osamu; Matsumoto, T; Matsuzaki, Yutaka

doi:10.1078/0344-0338-00006

Cited by 35 publications

(37 citation statements)

References 14 publications

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“…Leiomyosarcomas are malignant smooth muscle tumors that are generally less aggressive then squamous cell carcinoma of the esophagus, thus having better survival, which is consistent with our observations [23,24]. Unfortunately, 6 patients survived less than 1 year after resection; they included patients with GIST, undifferentiated carcinoma, lymphoma, sarcoma, and sarcomatoid carcinoma [25][26][27]. The variety of pathologic features in this group of patients surviving less than 1 year can be attributed to low sample size, but it also highlights the aggressive nature of these cancers.…”

Section: Commentsupporting

confidence: 89%

Surgical Resection of Rare Esophageal Cancers

Saddoughi

Taswell

Harmsen

et al. 2016

The Annals of Thoracic Surgery

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Section: Commentsupporting

confidence: 89%

Surgical Resection of Rare Esophageal Cancers

Saddoughi

Taswell

Harmsen

et al. 2016

The Annals of Thoracic Surgery

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“…2). All four cases (case 3, 4, 5, and 7) with CIS and ISCC contained more secondary LOHs in the CIS rather (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) than in the ISCC. Of the six cases with ISCC and SA, four (case 3, 4, 7, and 8), one (case 5), and one (case 6) had the greater, equal, and fewer numbers of secondary LOHs in a SA component, respectively.…”

Section: Analysis Of Chromosomal Lossmentioning

confidence: 92%

“…Sarcomatoid carcinoma of the esophagus is unusual [14,15,20,21,23] and is defined as a squamous cell carcinoma (SCC) with a variable sarcomatoid spindle cell (SA) component [6]. It is also known as a SCC with a spindle cell component, a spindle cell carcinoma, a pseudosarcomatous SCC, and a carcinosarcoma [6,11,12,14,20,21,25].…”

Section: Introductionmentioning

confidence: 99%

Extensive and divergent chromosomal losses in squamous and spindle-cell components of esophageal sarcomatoid carcinoma

et al. 2003

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Sarcomatoid carcinoma of the esophagus is an unusual type of squamous cell carcinoma (SCC) with a variable component of sarcomatoid spindle cells (SA). The loss of heterozygosity (LOH) involving multiple cancer-associated chromosomal arms has been reported to have a concerted, rather than an individual, effect on tumor progression. In order to delineate the role of LOH in the evolution of a biphasic tumor, the carcinoma in situ (CIS), invasive squamous cell carcinoma (ISCC), and SA components from a sarcomatoid carcinoma of the esophagus were compared for their clonality and extent of LOH. Forty microsatellite markers on the cancer-associated chromosomes, 3p, 4p, 5q, 8p, 9p, 13q, 17p, and 18q, were used for the polymerase chain reaction-based LOH analysis. All eight sarcomatoid carcinomas tested revealed extensive LOHs, involving an average of seven chromosomal arms. All CIS, ISCC, and SA components carried not only a high-level primary LOH (mean chromosomal involvement, 5.3) in common but also a low-level secondary LOH (mean chromosomal involvement, 1.8) in disparity. Interestingly, more secondary LOHs were always burdened in the CIS (four cases) rather than the matched ISCC. SA had a greater (four cases), equal (one case), or fewer (one case) number of secondary LOHs than ISCC. Given that excessive chromosomal losses may confer a disadvantage for tumor growth or a benefit for a metaplastic transformation, these results suggest that the multidirectional differentiation of a SCC precursor is stimulated by extensive and divergent LOHs acquired at the initial or early stages, and a precursor burdened with excessive LOH either remains in CIS or expands as a SA component.

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“…Sarcomatoid carcinomas demonstrated very rarely to be "collision tumors" with sharply defined sarcomatous and carcinomatous components without any shared or transitional features. There is, however, strong molecular evidence that supports the monoclonal origin of most sarcomatoid carcinomas [30] . Several genetic studies involving loss of heterozygosity (LOH) with microsatellite markers and pattern of X chromosome inactivation have demonstrated a common origin of the admixed components [31,32] .…”

Section: Discussionmentioning

confidence: 99%