A case of erosive lichen planus with plantar involvement

Kılıç, Fatma Arzu; Baysak, Sevim; Eşim, Ali Gökhan; Lebe, Banu

doi:10.4274/turkderm.48991

Cited by 3 publications

(16 citation statements)

References 11 publications

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“…Bu olguda olduğu gibi izole bir tutulum olarak eroziv plantar liken planus karşımıza çıktığında eroziv plantar liken planusu tanımak zor olabilir. Eroziv plantar liken planusu şiddetli egzamadan, tabanda lokalize büllöz pemfigoidden ve kemoterapötik ilaç toksisitesine bağlı oluşan plantar eritrodizesteziden ayırt etmek gerekir [2,3]. Öyküsünde kemoterapötik ilaç olmayan olgumuz histopatolojik bulgularla bu hastalıklardan ayrılmıştır.…”

Section: Discussionunclassified

“…Öyküsünde kemoterapötik ilaç olmayan olgumuz histopatolojik bulgularla bu hastalıklardan ayrılmıştır. Eroziv plantar liken planusun kadınlarda daha sık olduğu gösterilmiştir [3]. Otoimmün süreçlerin, eroziv plantar liken planusa sebep olduğu düşünülmektedir.…”

Section: Discussionunclassified

“…Palmoplantar liken planusun birçok klinik formu vardır, en sık eritemli-skuamlı lezyonların olduğu form görülürken daha az sıklıkla vezikül ve peteşi benzeri lezyonların olduğu formlar görülür [2]. Eroziv veya ülseratif liken planus, klasik liken planusun çok ender görülen bir formudur ve daha ziyade oral ve genital mukozaları tutar [2,3]. Eroziv plantar liken planus literatürde çok az sayıda bildirilmiştir [3].Ender görülmesi sebebiyle tedavisi standardize edilememiştir [3].…”

Section: Introductionunclassified

“…Eroziv veya ülseratif liken planus, klasik liken planusun çok ender görülen bir formudur ve daha ziyade oral ve genital mukozaları tutar [2,3]. Eroziv plantar liken planus literatürde çok az sayıda bildirilmiştir [3].Ender görülmesi sebebiyle tedavisi standardize edilememiştir [3]. Literatürde otoimmün tiroidit, primer bilier siroz ve Sjögren sendromu ile birliktelikler bildirilmiştir [3,4].…”

Section: Introductionunclassified

“…Eroziv plantar liken planus literatürde çok az sayıda bildirilmiştir [3].Ender görülmesi sebebiyle tedavisi standardize edilememiştir [3]. Literatürde otoimmün tiroidit, primer bilier siroz ve Sjögren sendromu ile birliktelikler bildirilmiştir [3,4]. Bu kadın olguyu klasik liken planusun nadir bir varyantı olması, tanı ve tedavisindeki zorluklar ve Sjögren sendromuna eşlik etmesi nedeniyle sunmayı uygun bulduk.…”

Section: Introductionunclassified

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Eroziv plantar liken planus: Olağan bir hastalığın nadir klinik varyantı

Gökşin

Duygulu

Kaçar

et al. 2020

Pamukkale Medical Journal

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Makale bilim dalı: Dermatoloji Makale başlığı: Eroziv plantar liken planus: olağan bir hastalığın nadir klinik varyantı. Kısa başlık: Eroziv plantar liken planus olgusu. Özet: Liken planus sık görülen mukoza ve deriyi tutan inflamatuar bir hastalıktır. Liken planus insidansı %0,1-4'tür. Palmoplantar liken planus ise hastalığın nadir görülen bir variantıdır. Palmoplantar liken planus'un birçok klinik formu vardır. Eroziv veya ülseratif

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Section: Discussionunclassified

Section: Introductionunclassified

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Eroziv plantar liken planus: Olağan bir hastalığın nadir klinik varyantı

Gökşin

Duygulu

Kaçar

et al. 2020

Pamukkale Medical Journal

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Successful treatment of resistant plantar ulcerative lichen planus with tofacitinib: A case report and comprehensive review of the literature

Bazargan,

Jafarzadeh,

Nobari

2023

Clinical Case Reports

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Key Clinical MessageUlcerative lichen planus, a challenging variant of lichen planus, has limited response to traditional treatments. Tofacitinib, a JAK–STAT pathway inhibitor, shows promise in effectively treating these lesions.AbstractLichen planus is a mucocutaneous disease that can cause various manifestations, such as itchy erythematous papules, cicatricial alopecia, erosion, and mucocutaneous ulcers. One uncommon manifestation of this disease is the occurrence of erosion and skin ulcers in the soles of the feet, which can cause many problems for patients. Tofacitinib, a Janus Kinase (JAK) inhibitor drug, has found a special place in the field of inflammatory diseases, especially inflammatory skin diseases. In this regard, studies on the effective role of this drug in the treatment of certain forms of lichen planus, including lichen planopilaris, and erosive lichen planus have been performed. In upcoming study, we introduce a 52‐year‐old woman with lichen planus who complained of ulcerative lesions on the sole of her foot, for whom a diagnosis of plantar ulcerative lichen planus was proposed. After the patient did not respond therapeutically to intralesional triamcinolone acetonide injection, as well as methotrexate and cyclosporine tablets, significant improvement was finally achieved with a 5 mg twice daily dose of tofacitinib. In the following, we will comprehensively review previous articles on the role of tofacitinib in the treatment of lichen planus lesions, as well as the proposed treatment options for erosive and ulcerative lichen planus lesions specifically located on the sole of the foot. Despite limited reports of the successful treatment of mucosal erosive lesions in the oral, esophageal, genital, and ocular mucosa areas with tofacitinib, no previous study has reported the successful treatment of ulcerative lichen planus lesions of the plantar area with tofacitinib. While reporting this case, we recommend considering tofacitinib as a treatment option for plantar ulcerative lichen planus. To confirm its effectiveness, it is necessary to conduct more extensive studies with a larger sample size.

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Integrative Approaches for the Diagnosis and Management of Erosive Oral Lichen Planus

Popa,

Sciuca,

Onofrei

et al. 2024

Diagnostics

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Erosive oral lichen planus (EOLP) represents a significant challenge in dental and medical management due to its chronic inflammatory nature, painful symptoms, and impact on quality of life. This study aims to evaluate the current diagnostic approach with novel non-invasive techniques, such as dermoscopy, and also the landscape of treatment options for EOLP, focusing on its efficacy, safety, and the challenges that it present in clinical practice. Through a comprehensive literature review, we explored the use of topical corticosteroids, systemic immunosuppressants, biologics, and Janus kinase (JAK) inhibitors in treating EOLP, alongside examining patient compliance, psychological impacts, and the risk of adverse effects and recurrence. Our findings reveal that while topical corticosteroids are the cornerstone of EOLP treatment, offering symptomatic relief, their long-term use is limited by side effects and tolerance development. Systemic therapies and biologics provide alternatives for refractory cases but necessitate careful adverse effect monitoring. JAK inhibitors show promise as an innovative treatment avenue but require more evidence on long-term safety and efficacy. This study highlights the necessity of personalized treatment approaches due to the variable disease course and response to treatment, underscoring the importance of a multidisciplinary strategy in managing EOLP. The complexity of EOLP treatment, compounded by its psychological and quality of life impacts, demands ongoing research into targeted therapies, the establishment of standardized treatment protocols, and the development of effective outcome measures to improve patient care and treatment outcomes.

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A case of erosive lichen planus with plantar involvement

Cited by 3 publications

References 11 publications

Eroziv plantar liken planus: Olağan bir hastalığın nadir klinik varyantı

Eroziv plantar liken planus: Olağan bir hastalığın nadir klinik varyantı

Successful treatment of resistant plantar ulcerative lichen planus with tofacitinib: A case report and comprehensive review of the literature

Integrative Approaches for the Diagnosis and Management of Erosive Oral Lichen Planus

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