A case of epithelioid haemangioendothelioma (EHE) of the lung with bronchial brushing cytology

Kumar, Ritesh; Smith, D. A.; Hilton, Colin J.; Parums, Dinah V.

doi:10.1046/j.1365-2303.1999.00111.x

Cited by 10 publications

(11 citation statements)

References 7 publications

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“…The final diagnosis of EHE was established by immunohistochemical stains performed on either cell block 10 or subsequent biopsy material. Cytological diagnosis of EHE in respiratory specimens 15,16 and pleural fluid 17 has been reported; however a well-established previous clinical history was available for each case.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration biopsy of epithelioid hemangioendothelioma of the oral cavity: Report of one case and review of literature

et al. 2006

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Epithelioid hemangioendothelioma (EHE) is an uncommon vascular tumor with biological behavior intermediate between hemangioma and angiosarcoma. It rarely occurs in the oral cavity. We report a case of an 81-yr-old woman with a 2-mo history of a 2 x 2 cm2 submucosal buccal mass. Fine needle aspiration (FNA) smears were paucicellular and showed mainly single atypical large epithelioid cells in a bloody background. The atypical cells had abundant dense cytoplasm, some with fine vacuoles. Occasionally, cells with large cytoplasmic lumina were seen. Cytology preparations from fresh tissue received for frozen section revealed numerous neoplastic cells with large intracytoplasmic lumina, some of which contained red blood cells. In addition, cells with distinct intranuclear inclusions were present. Histologic sections and immunohistochemical stains confirmed the diagnosis of EHE. Although the histologic features of EHE are well recognized, reports of FNA cytology findings are sparsely existent in the literature as several case reports. The characteristic cytological features of EHE are reviewed in this report. We believe that the diagnosis of this rare tumor can be suggested when an adequate FNA specimen is obtained.

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Section: Discussionmentioning

confidence: 99%

Fine needle aspiration biopsy of epithelioid hemangioendothelioma of the oral cavity: Report of one case and review of literature

et al. 2006

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“…On light microscopy, PEH is characterized by cords or nets of epithelioid tumour cells with intracytoplasmic vacuoles scattered in myxohyaline stroma 1,3,5 . Immunohistochemical staining for endothelial cell marker such as CD34, CD31 and factor VIII is usually positive, 1,3,5 while tests for markers of epithelial, mesothelial, muscular, neural and histiocytic differentiation are negative 5,6 . The tumour cells of PEH also exhibit the features of endothelium 1,3,5 …”

Section: Discussionmentioning

confidence: 99%

“…The initially diagnosis is often one of metastatic carcinoma or chronic granulomatous disease. Some patients with PEH have presented with a solitary pulmonary nodule 11 or large mass 5,9 . Other atypical CT features have included diffuse glass ground opacity and irregular interstitial thickening, 12 which may be the predominant findings on CT or be found concurrently with nodules in both lungs 13 .…”

Section: Discussionmentioning

confidence: 99%

Pulmonary epithelioid haemangioendothelioma mimicking central lung cancer

Shang

Wang

2009

Respirology

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A 40-year-old woman was hospitalized for investigation of dry cough, dyspnoea, and pain and swelling in the large joints of the arms and legs. Chest CT revealed a left hilar mass with partial atelectasis in the apical segment of the left lower lobe. X-ray of the wrists, elbows, ankles and knee joints showed a periosteal reaction, associated with hypertrophic pulmonary osteoarthropathy. Endobronchial biopsy suggested a pulmonary epithelioid haemangioendothelioma. Whole left lung resection was performed and the patient died of respiratory failure 1 month postoperatively.

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“…The diagnosis usually requires histopathological identification of neoplastic cells with immunostaining positive for CD31 3. A biopsy is always taken by video-assisted thoracoscopy, except a few reported cases that had biopsies taken by fibreoptic bronchoscopy 4 5. Treatment depends on the number and site of the nodules, with surgery preferred for solitary unilateral nodules and chemotherapy for multiple bilateral lesions 1 6 7.…”

Section: Introductionmentioning

confidence: 99%

Lung lobar collapse as the first manifestation of pulmonary epithelioid haemangioendothelioma diagnosed with fibreoptic bronchoscopy

et al. 2016

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Pulmonary epithelioid haemangioendothelioma (PEH) is a rare tumour of endothelial origin that usually occurs in the lung and liver. It usually presents as bilateral multiple nodular lesions. We report a middle-aged woman with a unique presentation of PEH with lung lobar collapse. The diagnosis was made with fibreoptic bronchoscopy rather than video-assisted thoracoscopy. Clinicians and pathologists should be aware of rare conditions that can present as lung lobar collapse.

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A case of epithelioid haemangioendothelioma (EHE) of the lung with bronchial brushing cytology

Cited by 10 publications

References 7 publications

Fine needle aspiration biopsy of epithelioid hemangioendothelioma of the oral cavity: Report of one case and review of literature

Fine needle aspiration biopsy of epithelioid hemangioendothelioma of the oral cavity: Report of one case and review of literature

Pulmonary epithelioid haemangioendothelioma mimicking central lung cancer

Lung lobar collapse as the first manifestation of pulmonary epithelioid haemangioendothelioma diagnosed with fibreoptic bronchoscopy

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