A case of epidermodysplasia verruciformis (EV) with human papillomavirus 16 (HPV16) DNA detected in the skin lesions: can HPV16 infect patients with EV?

Prospective study of genital human papillomaviruses and nonmelanoma skin cancer

“…Although some studies detecting HPV DNA on skin have either not found or only rarely found mucosal types, other studies have reported high‐risk mucosal types in NMSC, in cutaneous melanoma and in the skin malignancy Bowen's disease of the fingers . HPV16 has also been reported in a basal cell carcinoma (BCC) of the skin in a patient suffering from the hereditary immunodeficiency disease epidermodysplasia verruciformis …”

“…19,20 HPV16 has also been reported in a basal cell carcinoma (BCC) of the skin in a patient suffering from the hereditary immunodeficiency disease epidermodysplasia verruciformis. 21 HPV vaccination programs using either a vaccine containing the two common high-risk mucosal types, HPV16 and 18, or a vaccine containing both HPV16 and 18 as well as the two low-risk types HPV 6 and 11, have been introduced worldwide. These vaccination programs are expected to reduce anogenital cancers, but it has also been suggested that they will affect the incidence of other cancers caused by the types included in the vaccines, such as some head and neck cancers 22 and conjunctival cancers.…”

“…These vaccination programs are expected to reduce anogenital cancers, but it has also been suggested that they will affect the incidence of other cancers caused by the types included in the vaccines, such as some head and neck cancers and conjunctival cancers . If it is true, as some studies have indicated, that high‐risk mucosal HPV types are also a risk factor for some NMSC, it has been suggested that also the incidence of NMSC will be affected by the HPV vaccination programs.…”