A Case of Eosinophilic Gastroenteritis Associated with Eosinophilic Ascites Diagnosed by Full-Thickness Biopsy of the Small Intestine

Abstract

Patient: Male, 28Final Diagnosis: Eosinophilic gastroentritisSymptoms: Abdominal and/or epigastric pain • ascitesMedication: —Clinical Procedure: Full-thickness biopsySpecialty: Diagnostics, LaboratoryObjective:Unusual clinical courseBackground:Eosinophilic gastroenteritis is a rare disease, characterized by infiltrates of eosinophils in the intestinal mucosa, muscularis propria, and serosa. Eosinophilic gastroenteritis is due to Type 1 hypersensitivity and can be associated with other atopic diseases. The clinical course of eosinophilic gastroenteritis varies depending on the location, extent, and depth of eosinophilic infiltration of the gastrointestinal tract, which can make the diagnosis challenging. A case of eosinophilic gastroenteritis associated with eosinophilic ascites is presented that emphasizes the importance of full-thickness intestinal biopsy, which includes the muscularis propria, to allow the definitive diagnosis to be made.Case Report:A 28-year-old man presented with vague abdominal pain, nonspecific gastrointestinal symptoms, unintentional weight loss, and progressive ascites during the previous several months. A diagnosis of eosinophilic gastroenteritis was made after the exclusion of other possible causes, which was confirmed by histopathology of a full-thickness intestinal biopsy. The patient was treated with steroids. At one-month follow-up, the patient reported reduced abdominal pain.Conclusions:A case of eosinophilic gastroenteritis associated with eosinophilic ascites is presented that emphasizes the importance of full-thickness intestinal biopsy, which includes the muscularis propria, to allow the definitive diagnosis to be made.

Clinical and Morphological Diagnosis of Eosinophilic Gastric Enteritis (Literature Review)

“…Незважаючи на те, що різні інструментальні методи можуть допомогти в отриманні біопсії, деякі автори кращим методом вважають лапароскопічне хірургічне втручання, яке забезпечує взяття зразків всієї товщі стінки шлунка або кишечника для найбільш точного діагнозу, особливо при м'язовому та серозному підтипах захворювання [10,22]. Проте, такий метод не може бути широко розповсюджений, особливо у дітей, у зв'язку з високою інвазивністю та можливим розвитком ускладнень.…”