A case of enteropathy-associated T-cell lymphoma (Type I) arising in stomach without refractory celiac disease

Wang, Liang; Liu, Yang; Lin, Xu‐Yong; Yu, Juan‐Han; Miao, Yuan; Qiu, Xueshan; Wang, Enhua

doi:10.1186/1746-1596-7-172

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…Further, H. pylori infection correlates with MALT lymphoma, and MALT lymphomas express B-cell lineage markers. 8 However, in the present case CD138 immunostaining was positive and a Giemsa stain was negative. Some studies have reported the complete regression of EMPs after treatment for H. pylori .…”

Section: Discussioncontrasting

confidence: 54%

Successful Treatment of a Gastric Plasmacytoma Using a Combination of Endoscopic Submucosal Dissection and Oral Thalidomide

et al. 2014

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We report a rare case of a gastric plasmacytoma treated with endoscopic resection and oral thalidomide therapy. A 70-year-old man was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The patient was diagnosed with extramedullary gastric plasmacytoma. Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The patient's condition was found to be stable.

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Section: Discussioncontrasting

confidence: 54%

Successful Treatment of a Gastric Plasmacytoma Using a Combination of Endoscopic Submucosal Dissection and Oral Thalidomide

et al. 2014

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“…In absence of mass formation, EATL can be confused with an inflammatory ulcer, but the presence of atypical cells in EATL excludes this diagnosis (10,11). B cell lymphomas, poorly differentiated carcinomas, and benign lesions were excluded in our case with the presence of monomorphic atypical tumor cells stained positively for T lymphocyte markers.…”

Section: Discussionmentioning

confidence: 94%

Perforation of the small intestine caused by enteropathy-associated T cell lymphoma

et al. 2018

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Perforation of the small intestine caused by enteropathyassociated T cell lymphoma Enteropathy-associated T cell lymphoma is a rare lymphoma specific to the gastrointestinal system, arising from intraepithelial T lymphocytes, that is often associated with celiac disease. We report a 53-year-old female patient with no previous disease who presented with severe abdominal pain. Physical examination revealed diffuse abdominal tenderness and abdominal guarding and the patient underwent emergency surgery with a diagnosis of acute abdomen. During the operation, a 20-cm mass was found located on Treitz ligament, invading the duodenum and pancreatic head and perforating the jejunum. Histologically, medium-sized monomorphic atypical lymphocyte infiltration with dark nucleus and narrow cytoplasm was seen in the layers of mucosa, submucosa, muscular wall, and serosa of the duodenum. The final pathological diagnosis was "enteropathy-associated T cell lymphoma type 2" based on immunohistochemical and serological findings. Based on the World Health Organization 2008 criteria, enteropathy-associated T cell lymphoma has two subtypes. Type 1 enteropathy-associated T cell lymphoma is associated with celiac disease and has HLA DQ2 and HLA DQ8 genotype. Enteropathy-associated T cell lymphoma 2 enteropathy-associated T cell lymphoma seldom occurs and is not associated with celiac disease.

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“…EATL type I possesses large or pleomorphic cells that are express CD3, partially express CD30, but usually do not express CD8 and CD56. EATL also lacks EBV RNA expression in an EBER in situ hybridization ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report

Zhang

Wen

et al. 2015

Oncology Letters

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The majority of natural killer (NK)/T-cell lymphomas occur in the nasal cavity and rarely involve the stomach. They possess a specific immunophenotype, with the expression of cluster of differentiation (CD)56, CD2 and CD3ε, but without CD3 expression. Few cases of NK/T-cell lymphoma have partial CD30 expression. The present study reveals a unique case of a 41-year-old female patient with gastric NK/T-cell lymphoma that did not express CD56 and diffusely expressed CD30. Immunohistochemical staining demonstrated that the tumor cells expressed CD3ε, CD43, CD30 and granzyme B and did not express CD2, CD4, CD5, CD7, CD8, CD56, anaplastic lymphoma kinase, CD20, paired box-5 or pan cytokeratin. Based on the immunostaining profile and morphological features, the initial diagnosis considered was gastric anaplastic large cell lymphoma. However, following a consultation with other pathologists, the Epstein-Barr virus (EBV) status of the patient was investigated to exclude a diagnosis of NK/T-cell lymphoma. Notably, the signal for EBV RNA was diffuse positive. Therefore, the final diagnosis was corrected to NK/T-cell lymphoma. To the best of our knowledge, the present study is the first to report NK/T-cell lymphoma in the stomach with a diffuse CD30-positive and CD56-negative phenotype.

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A case of enteropathy-associated T-cell lymphoma (Type I) arising in stomach without refractory celiac disease

Cited by 10 publications

References 15 publications

Successful Treatment of a Gastric Plasmacytoma Using a Combination of Endoscopic Submucosal Dissection and Oral Thalidomide

Successful Treatment of a Gastric Plasmacytoma Using a Combination of Endoscopic Submucosal Dissection and Oral Thalidomide

Perforation of the small intestine caused by enteropathy-associated T cell lymphoma

Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report

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