A Case of Endocrine Cell Carcinoma Combined With Squamous Cell Carcinoma of the Esophagus Resected by Endoscopic Submucosal Dissection

Abstract

: A 55 -year -old man with esophageal carcinoma received endoscopic submucosal dissection (ESD) in en -bloc resection. Histopathological examination revealed an admixture of squamous cell carcinoma (SCC) and endocrine cell carcinoma (ECC) with invasion of the deep submucosa. Immunohistochemically, CD 56 and chromogranin A were positive for ECC. Small -cell, mediumcell, and large -cell type ECC were partly surrounded with SCC and partly formed the duct, presenting various patterns. After ESD, he received chemotherapy including CPT -11 plus Cisplatin. He is alive and in good condition today, 55 months after ESD, with no evidence of recurrence.

Composite neuroendocrine carcinoma and squamous cell carcinoma with regional lymph node metastasis: a case report

“…The therapeutic strategy for NEC of the esophagus has not been well defined because of the small number of cases [ 10 ]. To date, there has only been one case of collision of SCC and NEC of the esophagus treated by ESD [ 4 ].…”

“…Characteristic endoscopic features of NEC include submucosal growth, which is usually covered by normal epithelium with or without an ulcerous lesion in the center [ 8 ]. Biopsy sometimes fails to reach any diagnosis of NEC before treatment [ 4 ]. In our case, the microvascular pattern showed irregular, fine, reticular blood vessels near the center of the lesion.…”

“…Superficial NEC of the esophagus is rare. To the best of our knowledge, only a few superficial NECs of the esophagus have been reported in the English literature [ 4 ]. Accordingly, the characteristic endoscopic features and diagnosis of superficial NEC remain to be established.…”

Endoscopic submucosal dissection for an early-stage neuroendocrine carcinoma composited with squamous cell dysplasia

“…Histological diagnosis of neuroendocrine carcinoma by biopsy is difficult for it generally presents as a submucosal tumor covered by non-neoplastic epithelium [2]. On the other hand, neuroendocrine carcinomas sometimes have mixed components of squamous and/or glandular cells, which often lead to misdiagnosis [3]. The standard management of esophageal neuroendocrine carcinomas has not yet been established owing to the paucity of available data.…”